Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Viruses, Cells, and Animals
2.3. Mouse Experiments
2.4. Real-time RT-PCR for the Detection of JEV
2.5. Neutralizing Antibody Quantification Using the Plaque Reduction Neutralization Test
3. Results
3.1. Tissue Tropism of Intranasal Inoculation of JEV in Mice
3.2. Intranasal Inoculation Dose Response in the Lungs of Mice
3.3. Contact Transmission of JEV in Mice
3.4. Aerosol Transmission of JEV in Mice
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Chai, C.; Palinski, R.; Xu, Y.; Wang, Q.; Cao, S.; Geng, Y.; Zhao, Q.; Wen, Y.; Huang, X.; Yan, Q.; et al. Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus. Viruses 2019, 11, 87. https://doi.org/10.3390/v11010087
Chai C, Palinski R, Xu Y, Wang Q, Cao S, Geng Y, Zhao Q, Wen Y, Huang X, Yan Q, et al. Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus. Viruses. 2019; 11(1):87. https://doi.org/10.3390/v11010087
Chicago/Turabian StyleChai, Chunxia, Rachel Palinski, Yixuan Xu, Qiao Wang, Sanjie Cao, Yi Geng, Qin Zhao, Yiping Wen, Xiaobo Huang, Qiguai Yan, and et al. 2019. "Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus" Viruses 11, no. 1: 87. https://doi.org/10.3390/v11010087