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68 Results Found

  • Review
  • Open Access
48 Citations
12,381 Views
19 Pages

Patient No-Show Prediction: A Systematic Literature Review

  • Danae Carreras-García,
  • David Delgado-Gómez,
  • Fernando Llorente-Fernández and
  • Ana Arribas-Gil

17 June 2020

Nowadays, across the most important problems faced by health centers are those caused by the existence of patients who do not attend their appointments. Among others, these patients cause loss of revenue to the health centers and increase the patient...

  • Article
  • Open Access
2,921 Views
10 Pages

Understanding No-Show Patterns in Healthcare: A Retrospective Study from Northern Italy

  • Antonino Russotto,
  • Paolo Ragusa,
  • Dario Catozzi,
  • Aldo De Angelis,
  • Alessandro Durbano,
  • Roberta Siliquini and
  • Stefania Orecchia

Objectives: The aim of this study was to analyse no-show patterns in healthcare appointments, identify associated factors, and explore key determinants influencing non-attendance. Study Design: This was a retrospective observational study. Methods: W...

  • Article
  • Open Access
1 Citations
2,479 Views
14 Pages

Bringing Precision to Pediatric Care: Explainable AI in Predicting No-Show Trends Before and During the COVID-19 Pandemic

  • Quincy A. Hathaway,
  • Naveena Yanamala,
  • TaraChandra Narumanchi and
  • Janani Narumanchi

Patient no-shows significantly disrupt pediatric healthcare delivery, highlighting the necessity for precise predictive models, especially during the dynamic shifts caused by the SARS-CoV-2 pandemic. In outpatient settings, these no-shows result in m...

  • Article
  • Open Access
2 Citations
10,240 Views
17 Pages

A Solution to Reduce the Impact of Patients’ No-Show Behavior on Hospital Operating Costs: Artificial Intelligence-Based Appointment System

  • Kerem Toker,
  • Kadir Ataş,
  • Alpaslan Mayadağlı,
  • Zeynep Görmezoğlu,
  • Ibrahim Tuncay and
  • Rümeyza Kazancıoğlu

30 October 2024

Background: Patient no-show behavior is a critical factor complicating hospital resource optimization and causing waste. The inefficiency caused by patients’ no-shows and the resulting increased operating costs negatively affect the hospitals&r...

  • Article
  • Open Access
17 Citations
5,661 Views
14 Pages

No-show appointments waste resources and decrease the sustainability of care. This study is an attempt to evaluate patient no-shows based on modes of appointment-making and types of appointments. We collected hospital information system data and appo...

  • Article
  • Open Access
38 Citations
7,852 Views
21 Pages

Application of Machine Learning Techniques to Predict a Patient’s No-Show in the Healthcare Sector

  • Luiz Henrique A. Salazar,
  • Valderi R. Q. Leithardt,
  • Wemerson Delcio Parreira,
  • Anita M. da Rocha Fernandes,
  • Jorge Luis Victória Barbosa and
  • Sérgio Duarte Correia

22 December 2021

The health sector faces a series of problems generated by patients who miss their scheduled appointments. The main challenge to this problem is to understand the patient’s profile and predict potential absences. The goal of this work is to expl...

  • Article
  • Open Access
50 Citations
11,713 Views
12 Pages

Large-Scale No-Show Patterns and Distributions for Clinic Operational Research

  • Michael L. Davies,
  • Rachel M. Goffman,
  • Jerrold H. May,
  • Robert J. Monte,
  • Keri L. Rodriguez,
  • Youxu C. Tjader and
  • Dominic L. Vargas

16 February 2016

Patient no-shows for scheduled primary care appointments are common. Unused appointment slots reduce patient quality of care, access to services and provider productivity while increasing loss to follow-up and medical costs. This paper describes patt...

  • Article
  • Open Access
19 Citations
4,699 Views
9 Pages

Predictors of No-Show in Neurology Clinics

  • Hisham Elkhider,
  • Rohan Sharma,
  • Sen Sheng,
  • Jeff Thostenson,
  • Nidhi Kapoor,
  • Poornachand Veerapaneni,
  • Suman Siddamreddy,
  • Faisal Ibrahim,
  • Sisira Yadala and
  • Krishna Nalleballe
  • + 1 author

In this study, we aim to identify predictors of a no-show in neurology clinics at our institution. We conducted a retrospective review of neurology clinics from July 2013 through September 2018. We compared odds ratio of patients who missed appointme...

  • Article
  • Open Access
12 Citations
7,890 Views
13 Pages

No-Show in Medical Appointments with Machine Learning Techniques: A Systematic Literature Review

  • Luiz Henrique Américo Salazar,
  • Wemerson Delcio Parreira,
  • Anita Maria da Rocha Fernandes and
  • Valderi Reis Quietinho Leithardt

22 October 2022

No-show appointments in healthcare is a problem faced by medical centers around the world, and understanding the factors associated with no-show behavior is essential. In recent decades, artificial intelligence has taken place in the medical field an...

  • Article
  • Open Access
1 Citations
3,054 Views
14 Pages

Imaging Delay Following Liver-Directed Therapy Increases Progression Risk in Early- to Intermediate-Stage Hepatocellular Carcinoma

  • Jordin Stanneart,
  • Kelley G. Nunez,
  • Tyler Sandow,
  • Juan Gimenez,
  • Daniel Fort,
  • Mina Hibino,
  • Ari J. Cohen and
  • Paul T. Thevenot

2 January 2024

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths in the world. Patients with early-stage HCC are treated with liver-directed therapies to bridge or downstage for liver transplantation (LT). In this study, the...

  • Article
  • Open Access
13 Citations
9,221 Views
9 Pages

17 March 2015

Pediatric endoscopy has evolved into an indispensable tool in the diagnosis and management of gastrointestinal diseases in children. However, there is limited literature focusing on quality improvement initiatives in pediatric endoscopy. The primary...

  • Article
  • Open Access
1 Citations
2,749 Views
25 Pages

Effect of Disease Severity, Age of Child, and Clinic No-Shows on Unscheduled Healthcare Use for Childhood Asthma at an Academic Medical Center

  • Pavani Rangachari,
  • Imran Parvez,
  • Audrey-Ann LaFontaine,
  • Christopher Mejias,
  • Fahim Thawer,
  • Jie Chen,
  • Niharika Pathak and
  • Renuka Mehta

This study examines the influence of various individual demographic and risk factors on the use of unscheduled healthcare (emergency and inpatient visits) among pediatric outpatients with asthma over three retrospective timeframes (12, 18, and 24 mon...

  • Article
  • Open Access
74 Citations
10,589 Views
17 Pages

Agile Six Sigma in Healthcare: Case Study at Santobono Pediatric Hospital

  • Giovanni Improta,
  • Guido Guizzi,
  • Carlo Ricciardi,
  • Vincenzo Giordano,
  • Alfonso Maria Ponsiglione,
  • Giuseppe Converso and
  • Maria Triassi

Healthcare is one of the most complex systems to manage. In recent years, the control of processes and the modelling of public administrations have been considered some of the main areas of interest in management. In particular, one of the most probl...

  • Article
  • Open Access
2,302 Views
12 Pages

Background/Objectives: Missed outpatient appointments contribute to care discontinuity and emergency department (ED) overcrowding. This study investigated the association between missed appointments and ED visits, identifying predictors such as patie...

  • Article
  • Open Access
2 Citations
6,089 Views
9 Pages

Healthcare institutions generally use an appointment system. However, patients often need to receive medical services unexpectedly. If they visit a clinic without an appointment, they may have to wait for a long time, as their priority is low. In thi...

  • Article
  • Open Access
9 Citations
4,571 Views
10 Pages

Impact of Extreme Weather on Healthcare Utilization by People with HIV in Metropolitan Miami

  • Daniel Samano,
  • Shubhayu Saha,
  • Taylor Corbin Kot,
  • JoNell E. Potter and
  • Lunthita M. Duthely

Extreme weather events (EWE) are expected to increase as climate change intensifies, leaving coastal regions exposed to higher risks. South Florida has the highest HIV infection rate in the United States, and disruptions in clinic utilization due to...

  • Article
  • Open Access
4 Citations
5,299 Views
23 Pages

19 September 2018

Under the background of the unbalanced supply and demand of medical diagnostic equipment and rising health care costs, this study aims to optimize the service scheduling for medical diagnostic equipment so as to improve patient satisfaction by ensuri...

  • Article
  • Open Access
1 Citations
5,207 Views
16 Pages

SMS and Telephone Communication as Tools to Reduce Missed Medical Appointments

  • Michał Brancewicz,
  • Marlena Robakowska,
  • Marcin Śliwiński and
  • Dariusz Rystwej

5 September 2025

The aim of this study was to analyze the effectiveness of implementing an automated appointment confirmation system in a mental health clinic and to assess its impact on patient attendance, which may indirectly support the patient recovery process. T...

  • Article
  • Open Access
12 Citations
3,575 Views
14 Pages

A Mixed Methods Study Describing the Quality of Healthcare Received by Transgender and Gender Nonconforming Patients at a Large Integrated Health System

  • Suma Vupputuri,
  • Stacie L. Daugherty,
  • Kalvin Yu,
  • Alphonse J. Derus,
  • Laura E. Vasquez,
  • Ayanna Wells,
  • Christine Truong and
  • E. W. Emanuel

Transgender and gender nonconforming (TGNC) patients have been seeking medical care in higher numbers and have faced unique social, personal, and health issues that affect the quality of care they receive. The purpose of this study was to conduct a m...

  • Commentary
  • Open Access
49 Citations
7,844 Views
9 Pages

Perspectives of Registered Dietitian Nutritionists on Adoption of Telehealth for Nutrition Care during the COVID-19 Pandemic

  • Cory Brunton,
  • Mary Beth Arensberg,
  • Susan Drawert,
  • Christina Badaracco,
  • Wendy Everett and
  • Sharon M. McCauley

23 February 2021

Widespread transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global coronavirus disease 2019 (COVID-19) pandemic that is straining medical resources worldwide. In the United States (US), hosp...

  • Article
  • Open Access
4 Citations
4,569 Views
10 Pages

Patients with Axial Spondyloarthritis Show an Altered Flexion/Relaxation Phenomenon

  • I. Concepción Aranda-Valera,
  • Juan Luis Garrido-Castro,
  • Alfonso Martínez-Galisteo,
  • José Peña-Amaro,
  • Cristina González-Navas,
  • Antonio Cuesta-Vargas,
  • Luis Jiménez-Reina,
  • Eduardo Collantes-Estévez and
  • Clementina López-Medina

Axial spondyloarthritis (axSpA) is a chronic rheumatic disease characterized by the presence of inflammatory back pain. In patients with chronic low back pain, the lumbar flexion relaxation phenomenon measured by surface electromyography (sEMG) diffe...

  • Review
  • Open Access
270 Views
30 Pages

Telehealth for Sexual and Reproductive Healthcare: Evidence Map of Effectiveness, Patient and Provider Experiences and Preferences, and Patient Engagement Strategies

  • Romil R. Parikh,
  • Nishka U. Shetty,
  • Chinar Singhal,
  • Prachi Patel,
  • Priyanka Manghani,
  • Ashwin A. Pillai,
  • Luz Angela Chocontá-Piraquive and
  • Mary E. Butler

Objective: The aim of this study was to systematically map evidence to inform best practices for sexual and reproductive healthcare delivered via telehealth (TeleSRH) in United States-based Title X-funded clinics. Methods: We searched three databases...

  • Article
  • Open Access
8 Citations
3,174 Views
18 Pages

Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function

  • Dalia Rega,
  • Mika Aiko,
  • Nicolás Peñaranda,
  • Amparo Urios,
  • Juan-José Gallego,
  • Carla Giménez-Garzó,
  • Franc Casanova,
  • Alessandra Fiorillo,
  • Andrea Cabrera-Pastor and
  • Carmina Montoliu
  • + 14 authors

11 January 2021

Cirrhotic patients may experience alterations in the peripheral nervous system and in somatosensory perception. Impairment of the somatosensory system could contribute to cognitive and motor alterations characteristic of minimal hepatic encephalopath...

  • Article
  • Open Access
7 Citations
3,142 Views
13 Pages

3 September 2021

Introduction: Nailfold video capillaroscopy (NVC) is a useful tool for measuring capillary density (CD) and capillary morphology parameters and is mainly used in systemic sclerosis (SSc). Objective: We aimed to assess the prevalence of an SSc pattern...

  • Article
  • Open Access
9 Citations
3,369 Views
16 Pages

Pediatric Celiac Disease Patients Show Alterations of Dendritic Cell Shape and Actin Rearrangement

  • Valentina Discepolo,
  • Giuliana Lania,
  • Maria Leonarda Gertrude Ten Eikelder,
  • Merlin Nanayakkara,
  • Leandra Sepe,
  • Rossella Tufano,
  • Riccardo Troncone,
  • Salvatore Auricchio,
  • Renata Auricchio and
  • Maria Vittoria Barone
  • + 1 author

Celiac disease (CD) is a frequent intestinal inflammatory disease occurring in genetically susceptible individuals upon gluten ingestion. Recent studies point to a role in CD for genes involved in cell shape, adhesion and actin rearrangements, includ...

  • Article
  • Open Access
7 Citations
3,983 Views
16 Pages

hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers

  • Dulce Lima Cunha,
  • Amanda Oram,
  • Robert Gruber,
  • Roswitha Plank,
  • Arno Lingenhel,
  • Manoj K. Gupta,
  • Janine Altmüller,
  • Peter Nürnberg,
  • Matthias Schmuth and
  • Hans C. Hennies
  • + 3 authors

11 February 2021

Inherited ichthyoses represent a large heterogeneous group of skin disorders characterised by impaired epidermal barrier function and disturbed cornification. Current knowledge about disease mechanisms has been uncovered mainly through the use of mou...

  • Article
  • Open Access
47 Citations
5,446 Views
17 Pages

Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality

  • Yadira Palacios,
  • Andy Ruiz,
  • Lucero A. Ramón-Luing,
  • Ranferi Ocaña-Guzman,
  • Omar Barreto-Rodriguez,
  • Anahí Sánchez-Monciváis,
  • Brenda Tecuatzi-Cadena,
  • Ana G. Regalado-García,
  • Rey David Pineda-Gudiño and
  • Leslie Chavez-Galan
  • + 8 authors

Overproduction of inflammatory cytokines is a keystone event in COVID-19 pathogenesis; TNF and its receptors (TNFR1 and TNFR2) are critical pro-inflammatory molecules. ADAM17 releases the soluble (sol) forms of TNF, TNFR1, and TNFR2. This study evalu...

  • Article
  • Open Access
1,561 Views
18 Pages

Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients

  • Adianes Herrera-Diaz,
  • Rober Boshra,
  • Richard Kolesar,
  • Netri Pajankar,
  • Paniz Tavakoli,
  • Chia-Yu Lin,
  • Alison Fox-Robichaud and
  • John F. Connolly

13 February 2025

Background/Objectives: Coma prognosis is challenging, as patient presentation can be misleading or uninformative when using behavioral assessments only. Event-related potentials have been shown to provide valuable information about a patient’s...

  • Article
  • Open Access
6 Citations
2,223 Views
11 Pages

COVID-19 Patients with Early Gastrointestinal Symptoms Show Persistent Deficits in Specific Attention Subdomains

  • Juliana Schmidt,
  • Maria Cruz,
  • Julio Tolentino,
  • Aureo Carmo,
  • Maria Paes,
  • Glenda de Lacerda,
  • Ana Gjorup and
  • Sergio Schmidt

1 March 2023

Previous studies have shown that COVID-19 inpatients exhibited significant attentional deficits on the day of discharge. However, the presence of gastrointestinal symptoms (GIS) has not been evaluated. Here, we aimed to verify: (1) whether COVID-19 p...

  • Article
  • Open Access
19 Citations
4,180 Views
18 Pages

Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions

  • Marcos Pérez-Losada,
  • Eduardo Castro-Nallar,
  • José Laerte Boechat,
  • Luis Delgado,
  • Tiago Azenha Rama,
  • Valentín Berrios-Farías and
  • Manuela Oliveira

Allergic rhinitis and asthma are major public health concerns and economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with asthma comorbidity. To address this knowledge g...

  • Article
  • Open Access
8 Citations
3,593 Views
16 Pages

Uncharacterized RNAs in Plasma of Alzheimer’s Patients Are Associated with Cognitive Impairment and Show a Potential Diagnostic Power

  • Cristina Barbagallo,
  • Maria Teresa Di Martino,
  • Margherita Grasso,
  • Maria Grazia Salluzzo,
  • Francesca Scionti,
  • Filomena Irene Ilaria Cosentino,
  • Giuseppe Caruso,
  • Davide Barbagallo,
  • Cinzia Di Pietro and
  • Marco Ragusa
  • + 3 authors

15 October 2020

Alzheimer’s disease (AD) diagnosis is actually based on clinical evaluation and brain-imaging tests, and it can often be confirmed only post-mortem. Therefore, new non-invasive molecular biomarkers are necessary to improve AD diagnosis. As circ...

  • Article
  • Open Access
5 Citations
2,385 Views
13 Pages

Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma

  • Bo Young Hwang,
  • Jae Won Seo,
  • Can Muftuoglu,
  • Ufuk Mert,
  • Filiz Guldaval,
  • Milad Asadi,
  • Haydar Soydaner Karakus,
  • Tuncay Goksel,
  • Ali Veral and
  • Myeong Hee Moon
  • + 1 author

19 September 2023

A comprehensive lipid profile was analyzed in patients with non-small cell lung cancer (NSCLC) using nanoflow ultrahigh-performance liquid chromatography–electrospray ionization–tandem mass spectrometry. This study investigated 297 and 20...

  • Article
  • Open Access
656 Views
11 Pages

The Age Factor in Ixekizumab Survival: Older Patients Show Higher Long-Term Treatment Survival

  • Inés Noval-Martín,
  • Jorge Santos-Juanes,
  • Irene Álvarez-Losada,
  • Laura Palacios-García,
  • Ana Lozano-Blazquez,
  • Virginia García-Jimenez,
  • Cristina Galache Osuna and
  • Raquel Santos-Juanes Galache

12 October 2025

Background and Objectives: Ixekizumab is a human monoclonal antibody targeting interleukin-17A, approved for the treatment of moderate-to-severe plaque psoriasis. Given its demonstrated efficacy and safety in clinical trials, this study aimed to eval...

  • Article
  • Open Access
4 Citations
1,828 Views
10 Pages

7 December 2022

Background: At the dawn of the pandemic, severe forms of COVID-19 were often complicated by thromboembolisms. However, routine laboratory tests cannot be used to predict thromboembolic events. The objective of this study was to investigate the potent...

  • Article
  • Open Access
13 Citations
2,767 Views
12 Pages

miR-145, miR-92a and miR-375 Show Differential Expression in Serum from Patients with Diabetic Retinopathies

  • Adriana Solis-Vivanco,
  • Mónica Santamaría-Olmedo,
  • Dalila Rodríguez-Juárez,
  • Margarita Valdés-Flores,
  • Carlos González-Castor,
  • Rafael Velázquez-Cruz,
  • Eric Ramírez-Salazar,
  • Ana Cristina García-Ulloa and
  • Alberto Hidalgo-Bravo

21 September 2022

Diabetic retinopathies are important disabling conditions. Micro-RNAs (miRNAs) are regulators of gene expression and diseases can change their expression. Our aim was to analyze the expression of miRNAs in serum and vitreous samples from patients wit...

  • Article
  • Open Access
8 Citations
4,750 Views
25 Pages

The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap

  • Sharon J. Brown,
  • Rachel A. Kline,
  • Silvia A. Synowsky,
  • Sally L. Shirran,
  • Ian Holt,
  • Kelly A. Sillence,
  • Peter Claus,
  • Brunhilde Wirth,
  • Thomas M. Wishart and
  • Heidi R. Fuller

23 August 2022

Most research to characterise the molecular consequences of spinal muscular atrophy (SMA) has focused on SMA I. Here, proteomic profiling of skin fibroblasts from severe (SMA I), intermediate (SMA II), and mild (SMA III) patients, alongside age-match...

  • Article
  • Open Access
3 Citations
4,755 Views
17 Pages

Patients with Systemic Juvenile Idiopathic Arthritis (SJIA) Show Differences in Autoantibody Signatures Based on Disease Activity

  • Julie Krainer,
  • Michaela Hendling,
  • Sandra Siebenhandl,
  • Sabrina Fuehner,
  • Christoph Kessel,
  • Emely Verweyen,
  • Klemens Vierlinger,
  • Dirk Foell,
  • Silvia Schönthaler and
  • Andreas Weinhäusel

15 September 2023

Systemic juvenile idiopathic arthritis (SJIA) is a severe rheumatic disease in children. It is a subgroup of juvenile idiopathic arthritis (JIA; MIM #604302), which is the most common rheumatic disease in children. The diagnosis of SJIA often comes w...

  • Article
  • Open Access
2 Citations
2,146 Views
15 Pages

1 September 2023

(1) Background: Haematological malignancies (HMs) represent a heterogeneous group of mostly rare cancers that differ in pathophysiology, incidence, and outcome. (2) Methods: Our study aims to understand the epidemiological situation and trends of 24...

  • Article
  • Open Access
15 Citations
3,070 Views
10 Pages

Antibodies against HSV-1 and Curli Show the Highest Correlation in Parkinson’s Disease Patients in Comparison to Healthy Controls

  • Seyedesomaye Jasemi,
  • Kai Paulus,
  • Marta Noli,
  • Elena Rita Simula,
  • Stefano Ruberto and
  • Leonardo A. Sechi

26 November 2022

Parkinson’s disease (PD) is a neurodegenerative disorder involving the accumulation of alpha-synuclein (α-syn)/Lewy bodies in the brain and -enteric nervous system. The etiology of the disease is not well understood, but bacterial and vir...

  • Article
  • Open Access
23 Citations
7,207 Views
14 Pages

Hip Fracture Patients in Geriatric Rehabilitation Show Poor Nutritional Status, Dietary Intake and Muscle Health

  • Inge Groenendijk,
  • Charlotte S. Kramer,
  • Laura M. den Boeft,
  • Hans S. M. Hobbelen,
  • Gert-Jan van der Putten and
  • Lisette C. P. G. M. de Groot

20 August 2020

The aim of this study was to gain insight into the nutritional status, dietary intake and muscle health of older Dutch hip fracture patients to prevent recurrent fractures and to underpin rehabilitation programs. This cross-sectional study enrolled 4...

  • Article
  • Open Access
2,922 Views
14 Pages

Schizophrenia Patients Show Largely Similar Salience Signaling Compared to Healthy Controls in an Observational Task Environment

  • Adam J. Culbreth,
  • Zuzana Kasanova,
  • Thomas J. Ross,
  • Betty J. Salmeron,
  • James M. Gold,
  • Elliot A. Stein and
  • James A. Waltz

6 December 2021

Recent evidence suggests that the aberrant signaling of salience is associated with psychotic illness. Salience, however, can take many forms in task environments. For example, salience may refer to any of the following: (1) the valence of an outcome...

  • Article
  • Open Access
1,589 Views
11 Pages

‘Low-Plane’ Fractures of the Distal Humerus in Elderly Patients with Osteoporosis Show High Postoperative Complication Rates

  • Isabella Kuhn,
  • Sophia S. Goller,
  • Wolfgang Böcker,
  • Boris M. Holzapfel,
  • Daniel P. Berthold,
  • Fabian Gilbert and
  • Elisabeth Boehm

22 October 2024

Background: This study aimed to investigate the fracture patterns and complexity of distal humerus fractures with high-resolution computed tomography (CT) as a function of Dual-Energy X-ray absorptiometry (DXA)-derived bone marrow density (BMD) measu...

  • Article
  • Open Access
2 Citations
1,878 Views
19 Pages

23 July 2024

Degenerative disorders like osteoarthritis (OA) might impair the ability of tissue-resident mesenchymal stem/stromal cells (MSCs) for tissue regeneration. As primary cells with MSC-like properties are exploited for patient-derived stem cell therapies...

  • Article
  • Open Access
20 Citations
2,406 Views
23 Pages

Exosomes Released by Corneal Stromal Cells Show Molecular Alterations in Keratoconus Patients and Induce Different Cellular Behavior

  • Víctor Lozano,
  • Carla Martín,
  • Noelia Blanco,
  • Ignacio Alcalde,
  • Luis Fernandez-Vega Cueto,
  • Jesús Merayo-Lloves and
  • Luis M. Quirós

21 September 2022

Exosomes have been related to various disorders, but their study in relation to ocular pathologies has been limited. In this article, we analyze exosomes produced by corneal stromal cells from healthy individuals and from patients with keratoconus. T...

  • Article
  • Open Access
28 Citations
4,557 Views
11 Pages

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

  • Domenico De Rasmo,
  • Anna Ferretta,
  • Silvia Russo,
  • Maddalena Ruggieri,
  • Piergiorgio Lasorella,
  • Damiano Paolicelli,
  • Maria Trojano and
  • Anna Signorile

Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been report...

  • Article
  • Open Access
7 Citations
3,503 Views
14 Pages

Excitatory Neurons Derived from Human-Induced Pluripotent Stem Cells Show Transcriptomic Differences in Alzheimer’s Patients from Controls

  • Ram Sagar,
  • Ioannis Azoidis,
  • Cristina Zivko,
  • Ariadni Xydia,
  • Esther S. Oh,
  • Paul B. Rosenberg,
  • Constantine G. Lyketsos,
  • Vasiliki Mahairaki and
  • Dimitrios Avramopoulos

2 August 2023

The recent advances in creating pluripotent stem cells from somatic cells and differentiating them into a variety of cell types is allowing us to study them without the caveats associated with disease-related changes. We generated induced Pluripotent...

  • Brief Report
  • Open Access
730 Views
11 Pages

Amyotrophic Lateral Sclerosis Patients Show Higher Urinary Levels of Lead and Copper: A Pilot Case-Control Study

  • Ana Santurtún,
  • Lucía Pérez-Soberón,
  • María José Sedano and
  • Javier Riancho

29 September 2025

Background/Objectives: Amyotrophic Lateral Sclerosis (ALS) is the most frequent neurodegenerative disease affecting motor neurons. Sporadic ALS cases, which represent over 90% of the total, result from the interaction between genetic predisposition,...

  • Article
  • Open Access
2 Citations
4,688 Views
11 Pages

BCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of Mycobacterium tuberculosis-Specific IFN-γ Release

  • Dorcas O. Owusu,
  • Ernest Adankwah,
  • Wilfred Aniagyei,
  • Isaac Acheampong,
  • Difery Minadzi,
  • Augustine Yeboah,
  • Joseph F. Arthur,
  • Millicent Lamptey,
  • Monika M. Vivekanandan and
  • Marc Jacobsen
  • + 9 authors

17 April 2023

Mycobacterium (M.) bovis BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing sev...

  • Article
  • Open Access
5 Citations
2,213 Views
17 Pages

Patients with Inflammatory Bowel Disease Show Fewer Sex-Related Differences in Their Dietary Behavior Than the General Population: A Qualitative Analysis

  • Lea Pueschel,
  • Fabian Kockelmann,
  • Momme Kueck,
  • Uwe Tegtbur,
  • Masoumeh Attaran-Bandarabadi,
  • Oliver Bachmann,
  • Heiner Wedemeyer,
  • Henrike Lenzen and
  • Miriam Wiestler

2 September 2024

Background: Since diet is generally recognized as an important factor directly modulating the gut microbiome, it is also considered a potential environmental triggering factor for the pathogenesis and onset of inflammatory bowel disease (IBD). While...

  • Communication
  • Open Access
37 Citations
3,733 Views
9 Pages

Patients with Liver Cirrhosis Show High Immunogenicity upon COVID-19 Vaccination but Develop Premature Deterioration of Antibody Titers

  • Katharina Willuweit,
  • Alexandra Frey,
  • Moritz Passenberg,
  • Johannes Korth,
  • Nissrin Saka,
  • Olympia E. Anastasiou,
  • Birte Möhlendick,
  • Andreas Schütte,
  • Hartmut Schmidt and
  • Jassin Rashidi-Alavijeh

28 February 2022

SARS-CoV-2 infection is known to lead to severe morbidity and mortality in patients with liver cirrhosis. For this reason, vaccination of these patients against COVID-19 is widely recommended. However, data regarding immunogenicity in patients with l...

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