Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma
Abstract
:1. Introduction
2. Results
2.1. Identification and Target-Based Lipid Quantification
2.2. Alterations in Lipid Profiles of Saliva and Plasma Samples in NSCLC Patients
3. Discussion
4. Materials and Methods
4.1. Materials and Reagents
4.2. Human Samples
4.3. Lipid Extraction
4.4. Lipid Analysis with nUHPLC-ESI-MS/MS
4.5. Method Validation
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Saliva | Plasma | ||||
---|---|---|---|---|---|
Molecular Species | AUC | Molecular Species | AUC | Molecular Species | AUC |
PC 36:1 | 0.840 | PS 36:1 | 0.902 | PI 38:4 | 1.000 |
PC 36:2 | 0.831 | PS 36:2 | 0.928 | Cer d40:1 | 1.000 |
EtherPC O-34:1 & P-34:0 | 0.885 | PG 32:1 | 0.815 | Cer d42:1 | 1.000 |
EtherPC O-34:2 & P-34:1 | 0.817 | SM d42:1 | 0.881 | Cer d42:2 | 0.948 |
EtherPC O-36:2 & P-36:1 | 0.913 | SM d42:2 | 0.837 | TG 50:2 | 1.000 |
EtherPC O-36:3 & P-36:2 | 0.841 | HexCer d42:0 | 0.940 | TG 52:4 | 0.969 |
PE 32:1 | 0.866 | HexCer d42:2 | 0.872 | TG 52:5 | 0.927 |
EtherPE P-36:1 | 0.835 | Hex2Cer d42:2 | 0.861 | TG 54:5 | 0.912 |
PA 34:1 | 0.911 | DG 32:0 | 0.928 | TG 54:6 | 0.864 |
PA 34:2 | 0.872 | DG 34:1 | 0.872 | CE 18:2 | 0.930 |
PA 36:2 | 0.914 | DG 34:2 | 0.810 | ||
LPS 18:1 | 0.815 | TG 52:2 | 0.847 | ||
PS 34:1 | 0.936 | TG 52:3 | 0.806 | ||
TG 52:5 | 0.844 |
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Hwang, B.Y.; Seo, J.W.; Muftuoglu, C.; Mert, U.; Guldaval, F.; Asadi, M.; Karakus, H.S.; Goksel, T.; Veral, A.; Caner, A.; et al. Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma. Int. J. Mol. Sci. 2023, 24, 14264. https://doi.org/10.3390/ijms241814264
Hwang BY, Seo JW, Muftuoglu C, Mert U, Guldaval F, Asadi M, Karakus HS, Goksel T, Veral A, Caner A, et al. Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma. International Journal of Molecular Sciences. 2023; 24(18):14264. https://doi.org/10.3390/ijms241814264
Chicago/Turabian StyleHwang, Bo Young, Jae Won Seo, Can Muftuoglu, Ufuk Mert, Filiz Guldaval, Milad Asadi, Haydar Soydaner Karakus, Tuncay Goksel, Ali Veral, Ayse Caner, and et al. 2023. "Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma" International Journal of Molecular Sciences 24, no. 18: 14264. https://doi.org/10.3390/ijms241814264