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  • Article
  • Open Access
6 Citations
8,725 Views
20 Pages

A Microcavity Array-Based 4D Cell Culture Platform

  • Cordula Nies,
  • Tobias Rubner,
  • Hanna Lorig,
  • Vera Colditz and ,
  • Helen Seelmann,
  • Andreas Müller and
  • Eric Gottwald
  • + 2 authors+ 0 author

(1) Background: We describe a 4D cell culture platform with which we tried to detect and to characterize migration dynamics of single hematopoietic stem cells in polymer film microcavity arrays integrated into a microtiter plate. (2) Methods: The sys...

  • Article
  • Open Access
4 Citations
5,283 Views
20 Pages

9 October 2020

The sodium triple-quantum (TQ) magnetic resonance (MR) signal created by interactions of sodium ions with macromolecules has been demonstrated to be a valuable biomarker for cell viability. The aim of this study was to monitor a cellular response usi...

(This article belongs to the Section Biological Processes and Systems)
  • Communication
  • Open Access
721 Views
8 Pages

20 November 2025

We present a parallel DNA molecular analysis platform based on an array of plano-concave Fabry–Pérot (PC-FP) microcavity lasers that enables the simultaneous, sequence-specific detection of multiple DNA targets. Each PC-FP cavity is func...

  • Article
  • Open Access
33 Citations
7,865 Views
12 Pages

Top-Emitting Active-Matrix Quantum Dot Light-Emitting Diode Array with Optical Microcavity for Micro QLED Display

  • Kuo-Yang Lai,
  • Shuan Yang,
  • Tung-Chang Tsai,
  • I-An Yao and ,
  • Chiu-Lien Yang,
  • Chih-Ching Chang and
  • Hsueh-Shih Chen
  • + 2 authors+ 0 author

4 August 2022

An electroluminescent quantum-dot light-emitting diode (QLED) device and a micro QLED device array with a top-emitting structure were demonstrated in this study. The QLED device was fabricated in the normal structure of [ITO/Ag/ITO anode]/PEDOT:PSS/P...

(This article belongs to the Special Issue Recent Advances in Synthesis, Characterization and Applications of Functional Nanoparticles and Quantum Dots)
  • Article
  • Open Access
1 Citations
2,040 Views
9 Pages

Suppression of Secondary Electron Emission by Vertical Graphene Coating on Ni Microcavity Substrate

  • Xiaoning Zhang,
  • Bin Tang,
  • Jialong He,
  • Hui Zhao and ,
  • Ronghua Wang,
  • Hao Gui,
  • Xinlu Li,
  • Kefu Liu,
  • Jinshui Shi and
  • Guomei Chang
  • + 5 authors+ 0 author

29 July 2024

Suppression of secondary electron emission (SEE) from metal surfaces is crucial for enhancing the performance of particle accelerators, spacecraft, and vacuum electronic devices. Earlier research has demonstrated that either etching the metal surface...

(This article belongs to the Section Energy and Catalysis)
  • Feature Paper
  • Article
  • Open Access
3 Citations
4,259 Views
17 Pages

Hollow Microcavity Electrode for Enhancing Light Extraction

  • Seonghyeon Park,
  • Byeongwoo Kang,
  • Seungwon Lee,
  • Jian Cheng Bi and ,
  • Jaewon Park,
  • Young Hyun Hwang,
  • Jun-Young Park,
  • Ha Hwang,
  • Young Wook Park and
  • Byeong-Kwon Ju
  • + 5 authors+ 0 author

27 February 2024

Luminous efficiency is a pivotal factor for assessing the performance of optoelectronic devices, wherein light loss caused by diverse factors is harvested and converted into the radiative mode. In this study, we demonstrate a nanoscale vacuum photoni...

(This article belongs to the Special Issue Advanced Thin-Films: Design, Fabrication and Applications, 2nd Edition)
  • Article
  • Open Access
1,654 Views
16 Pages

Array-Patterned Anisotropic Conductive Films for High Precision Circuit Interconnection

  • Changxiang Hao,
  • Junde Chen,
  • Yonghao Chen,
  • Ge Cao and ,
  • Xing Cheng and
  • Yanqing Tian
  • + 1 author+ 0 author

28 October 2025

Anisotropic conductive films (ACFs) are widely used for circuit interconnection due to their easy use, low temperature bonding, higher precision than soldering and eco-friendliness. However, current ACFs are generally prepared by randomly distributin...

(This article belongs to the Section Advanced Composites)
  • Article
  • Open Access
21 Citations
3,650 Views
17 Pages

Study on the Influence of Microinjection Molding Processing Parameters on Replication Quality of Polylactic Acid Microneedle Array Product

  • Wenqian Yu,
  • Junfeng Gu,
  • Zheng Li,
  • Shilun Ruan and ,
  • Biaosong Chen,
  • Changyu Shen,
  • Ly James Lee and
  • Xinyu Wang
  • + 3 authors+ 0 author

27 February 2023

Biodegradable microneedles with a drug delivery channel have enormous potential for consumers, including use in chronic disease, vaccines, and beauty applications, due to being painless and scarless. This study designed a microinjection mold to fabri...

(This article belongs to the Special Issue Advances in Polymer Processing and Molding)
  • Article
  • Open Access
30 Citations
9,431 Views
15 Pages

23 November 2011

This paper develops a dielectrophoretic (DEP) chip with multi-layer electrodes and a micro-cavity array for programmable manipulations of cells and impedance measurement. The DEP chip consists of an ITO top electrode, flow chamber, middle electrode o...

(This article belongs to the Special Issue Biochips)
  • Article
  • Open Access
12 Citations
5,473 Views
10 Pages

25 March 2018

A diamond-like carbon (DLC) film, coated on an SKD11 (alloy tool steel) substrate, was shaped by plasma oxidation to form an assembly of DLC macro-pillars and to be used as a DLC-punch array that is micro-embossed into aluminum sheets. First, the SKD...

(This article belongs to the Special Issue Carbon Based Materials for MEMS/NEMS)
  • Review
  • Open Access
45 Views
40 Pages

31 October 2026

Whispering-gallery-mode (WGM) optical microcavity acoustic sensors have attracted extensive attention owing to their high sensitivity, broad bandwidth, miniaturization and anti-electromagnetic interference capability. This review systematically surve...

(This article belongs to the Section Optical Sensors)
  • Article
  • Open Access
3,471 Views
25 Pages

24 September 2025

The influence of axial ultrasonic vibration (the dominant vibration mode) on the filling behavior of polymer melt in microcavities and its effect on microstructure formation remains inadequately understood. Based on the plasticization location and th...

(This article belongs to the Special Issue Advances in Polymer Molding and Processing)
  • Article
  • Open Access
8 Citations
3,325 Views
9 Pages

18 February 2022

Metal nanoparticles supporting plasmons are widely used to enhance electromagnetic fields, resulting in strong light–matter interactions at the nanoscale in a diverse range of applications. Recently, it has been shown that when metal nanorods a...

(This article belongs to the Section Optical and Photonic Materials)
  • Article
  • Open Access
6 Citations
8,685 Views
33 Pages

13 December 2012

Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance...

(This article belongs to the Special Issue Ultra-Small Sensor Systems and Components)
  • Article
  • Open Access
6 Citations
6,620 Views
9 Pages

Self-Patterned Stretchable Electrode Based on Silver Nanowire Bundle Mesh Developed by Liquid Bridge Evaporation

  • Eun Young An,
  • Siyoung Lee,
  • Seung Goo Lee,
  • Eunho Lee and ,
  • Jeong Ju Baek,
  • Gyojic Shin,
  • Kyung Ho Choi,
  • Jeong Ho Cho and
  • Geun Yeol Bae
  • + 4 authors+ 0 author

27 October 2021

A new strategy is required to realize a low-cost stretchable electrode while realizing high stretchability, conductivity, and manufacturability. In this study, we fabricated a self-patterned stretchable electrode using a simple and scalable process....

(This article belongs to the Section Nanoelectronics, Nanosensors and Devices)
  • Article
  • Open Access
12 Citations
5,328 Views
12 Pages

Parallel Detection of Refractive Index Changes in a Porous Silicon Microarray Based on Digital Images

  • Chuanxi Li,
  • Zhenhong Jia,
  • Peng Li,
  • Hao Wen and ,
  • Guodong Lv and
  • Xiaohui Huang
  • + 1 author+ 0 author

2 April 2017

A new technique for the refractive index change with high-sensitivity measurements was proposed by the digital image of porous silicon (PSi) microarray utilization in this paper. Under the irradiation of a He-Ne laser, the surface images of the PSi a...

(This article belongs to the Special Issue Silicon Technologies for Photonic Sensors)
  • Article
  • Open Access
18 Citations
3,635 Views
12 Pages

Research on a Dual-Mode Infrared Liquid-Crystal Device for Simultaneous Electrically Adjusted Filtering and Zooming

  • Zhonglun Liu,
  • Mingce Chen,
  • Zhaowei Xin,
  • Wanwan Dai and ,
  • Xinjie Han,
  • Xinyu Zhang,
  • Haiwei Wang and
  • Changsheng Xie
  • + 3 authors+ 0 author

19 February 2019

A new dual-mode liquid-crystal (LC) micro-device constructed by incorporating a Fabry–Perot (FP) cavity and an arrayed LC micro-lens for performing simultaneous electrically adjusted filtering and zooming in infrared wavelength range is present...

(This article belongs to the Special Issue Optical MEMS)
  • Article
  • Open Access
17 Citations
5,918 Views
11 Pages

Regarding the fabrication of solar selective absorbers, the ability to create microstructures on top of metal surfaces is a promising technology. Typically, these materials are able to possess spectrally-selective absorption properties for high-tempe...

(This article belongs to the Special Issue 3D- and 2D-Nanofabrication for Photonic Devices)
  • Article
  • Open Access
3 Citations
2,954 Views
10 Pages

26 November 2020

A low-threshold miniaturized single-mode nanowire laser operating at telecommunication wavelengths was proposed and simulated. The device was constructed by combining a single InGaAs nanowire with a photonic crystal microcavity and asymmetric distrib...

(This article belongs to the Section Nanoelectronics, Nanosensors and Devices)
  • Article
  • Open Access
3 Citations
2,818 Views
11 Pages

We present an integrated device combining a double L-shaped chiral metasurface with long-wavelength GaAs/AlGaAs quantum well infrared photodetectors (QWIPs), achieving a circular polarized extinction ratio (CPER) as high as 45 in the long-wavelength...

(This article belongs to the Special Issue Advanced Photonic Sensing and Measurement II)
  • Review
  • Open Access
69 Citations
16,284 Views
21 Pages

In this review, we summarize recent works on perovskite solar cells with neutral- and multi-colored semitransparency for building-integrated photovoltaics and tandem solar cells. The perovskite solar cells exploiting microstructured arrays of perovsk...

(This article belongs to the Section Photochemistry)
  • Communication
  • Open Access
9 Citations
5,428 Views
9 Pages

Strong Coupling between Plasmonic Surface Lattice Resonance and Photonic Microcavity Modes

  • Yunjie Shi,
  • Wei Liu,
  • Shidi Liu,
  • Tianyu Yang and ,
  • Yuming Dong,
  • Degui Sun and
  • Guangyuan Li
  • + 2 authors+ 0 author

1 February 2022

We report the strong coupling between plasmonic surface lattice resonances (SLRs) and photonic Fabry-Pérot (F-P) resonances in a microcavity embedded with two-dimensional periodic array of metal-insulator-metal nanopillars. For such a plasmoni...

(This article belongs to the Section Optical Interaction Science)
  • Article
  • Open Access
7 Citations
3,383 Views
10 Pages

Nanoscale Characterization of Surface Plasmon-Coupled Photoluminescence Enhancement in Pseudo Micro Blue LEDs Using Near-Field Scanning Optical Microscopy

  • Yufeng Li,
  • Aixing Li,
  • Ye Zhang,
  • Peng Hu and ,
  • Wei Du,
  • Xilin Su,
  • Qiang Li and
  • Feng Yun
  • + 3 authors+ 0 author

15 April 2020

The microcave array with extreme large aspect ratio was fabricated on the p-GaN capping layer followed by Ag nanoparticles preparation. The coupling distance between the dual-wavelength InGaN/GaN multiple quantum wells and the localized surface plasm...

(This article belongs to the Section Nanophotonics Materials and Devices)
  • Article
  • Open Access
25 Citations
14,060 Views
17 Pages

9 October 2013

This paper presents the microfabrication of an acoustic impedance gradient matching layer on a spherically-shaped piezoelectric ultrasonic transducer. The acoustic matching layer can be designed to achieve higher acoustic energy transmission and oper...

(This article belongs to the Special Issue Modeling, Testing and Reliability Issues in MEMS Engineering 2013)
  • Article
  • Open Access
4 Citations
3,645 Views
9 Pages

Microfabrication of Ni-Fe Mold Insert via Hard X-ray Lithography and Electroforming Process

  • Jae Man Park,
  • Sung Cheol Park,
  • Da Seul Shin,
  • Jong Hyun Kim and ,
  • Hanlyun Cho,
  • Woo Seok Yang,
  • Seong Ho Son and
  • Seong Jin Park
  • + 3 authors+ 0 author

6 April 2020

In this research, a Ni-Fe mold insert for the efficient replication of high aspect-ratio microstructure arrays was fabricated via hard X-ray lithography and an electroforming process. For the X-ray exposure on a photoresist, a gold-based X-ray mask w...

  • Article
  • Open Access
18 Citations
6,905 Views
11 Pages

One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing

  • Mike Debono,
  • Dan Voicu,
  • Mohammad Pousti,
  • Muhammad Safdar and ,
  • Robert Young,
  • Eugenia Kumacheva and
  • Jesse Greener
  • + 2 authors+ 0 author

29 November 2016

We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templa...

(This article belongs to the Special Issue Microfluidics-Based Microsystem Integration Research)
  • Article
  • Open Access
4 Citations
4,201 Views
13 Pages

29 March 2023

Hexagonal cube corner retroreflectors (HCCRs) are the micro-optics arrays with the highest reflectivity. However, these are composed of prismatic micro-cavities with sharp edges, and conventional diamond cutting is considered unmachinable. Besides, 3...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
582 Views
19 Pages

30 April 2026

Broadband antireflective surface technology constitutes a crucial technique in optoelectronic devices, playing a key role in reducing optical losses. Ultrafast laser processing provides a flexible route for fabricating micro-nano structures on metall...

(This article belongs to the Section Crystalline Metals and Alloys)
  • Article
  • Open Access
7 Citations
5,207 Views
16 Pages

Fiber-Optic Hydraulic Sensor Based on an End-Face Fabry–Perot Interferometer with an Open Cavity

  • Oleg Morozov,
  • Timur Agliullin,
  • Airat Sakhabutdinov,
  • Artem Kuznetsov and ,
  • Bulat Valeev,
  • Mohammed Qaid,
  • Roman Ponomarev,
  • Danil Nurmuhametov,
  • Anastasia Shmyrova and
  • Yuri Konstantinov
  • + 5 authors+ 0 author

27 December 2023

The paper describes the design and manufacturing process of a fiber optic microphone based on a macro cavity at the end face of an optical fiber. The study explores the step-by-step fabrication of a droplet-shaped macro cavity on the optical fiber&rs...

(This article belongs to the Special Issue Fiber Optic Sensors: Science and Applications)
  • Article
  • Open Access
38 Citations
7,140 Views
9 Pages

Transdermal Polymeric Microneedle Sensing Platform for Fentanyl Detection in Biofluid

  • Pratik Joshi,
  • Parand R. Riley,
  • Rupesh Mishra,
  • Sina Azizi Machekposhti and
  • Roger Narayan

27 March 2022

Opioid drugs are extremely potent synthetic analytes, and their abuse is common around the world. Hence, a rapid and point-of-need device is necessary to assess the presence of this compound in body fluid so that a timely countermeasure can be provid...

(This article belongs to the Special Issue Feature Issue of Biosensor Materials Section)
  • Article
  • Open Access
577 Views
19 Pages

4 August 2026

In this study, we propose a novel optical sensor architecture based on two-dimensional photonic crystals for the early detection of cervical cancer (HeLa). The structure consists of a central hollow-disk micro-cavity designed to accommodate biosample...

(This article belongs to the Section Biosensors)
  • Article
  • Open Access
2,308 Views
31 Pages

High-Throughput Analysis of 3D Cell Culture Oxygen Consumption Using Sensor Arrays: A Novel Platform for Hypoxia/Normoxia Research

  • Christoph Grün,
  • Cordula Nies,
  • Magdalena Klesen,
  • Enja Schwarz and ,
  • Jonah ter Haseborg,
  • Cornelius Dettmer,
  • Christian Beyer,
  • Larissa Funk and
  • Eric Gottwald
  • + 4 authors+ 0 author

Precise control and measurement of the cellular microenvironment, particularly oxygen concentration, are crucial for developing physiologically relevant in vitro models. However, current methods often lack the spatial resolution and throughput needed...

  • Article
  • Open Access
25 Citations
3,554 Views
16 Pages

Longitudinal Evaluation of PD-L1 Expression on Circulating Tumor Cells in Non-Small Cell Lung Cancer Patients Treated with Nivolumab

  • Mio Ikeda,
  • Yasuhiro Koh,
  • Shunsuke Teraoka,
  • Koichi Sato and ,
  • Jun Oyanagi,
  • Atsushi Hayata,
  • Nahomi Tokudome,
  • Hiroaki Akamatsu,
  • Yuichi Ozawa and
  • Nobuyuki Yamamoto
  • + 9 authors+ 4 authors

11 May 2021

Although programmed death-ligand 1 (PD-L1) expression on tumor tissue is a validated predictive biomarker for a PD-1 pathway blockade in non-small cell lung cancer (NSCLC), longitudinal changes in its expression during treatment remains elusive. Circ...

(This article belongs to the Special Issue Liquid Biopsy in Cancer)
  • Article
  • Open Access
15 Citations
5,291 Views
22 Pages

Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients

  • Evan N. Cohen,
  • Gitanjali Jayachandran,
  • Hui Gao,
  • Phillip Peabody and ,
  • Heather B. McBride,
  • Franklin D. Alvarez,
  • Megumi Kai,
  • Juhee Song,
  • Yu Shen and
  • James M. Reuben
  • + 9 authors+ 4 authors

6 March 2023

Circulating tumor cells (CTCs) are indicators of metastatic spread and progression. In a longitudinal, single-center trial of patients with metastatic breast cancer starting a new line of treatment, a microcavity array was used to enrich CTCs from 18...

(This article belongs to the Collection Malignant and Non-malignant Atypical Circulating Cell in Cancer: Their Heterogeneity and Plasticity)
  • Article
  • Open Access
8 Citations
3,213 Views
14 Pages

Three-Dimensional Printing of Bioinspired Hierarchical Structures for Enhanced Fog Collection Efficiency in 3D Space via Vat Photopolymerization

  • Daleanna Charoensook,
  • Shah Md Ashiquzzaman Nipu,
  • Ana Girish,
  • Qingqing He and ,
  • Shan Cheng,
  • Kevin Chapman,
  • Nathan Xie,
  • Cindy Xiangjia Li and
  • Yang Yang
  • + 4 authors+ 0 author

Collecting fog water is crucial for dry areas since natural moisture and fog are significant sources of freshwater. Sustainable and energy-efficient water collection systems can take a page out of the cactus’s playbook by mimicking its native f...

(This article belongs to the Special Issue Bioinspired Engineering and the Design of Biomimetic Structures: 2nd Edition)
  • Article
  • Open Access
18 Citations
4,957 Views
15 Pages

Biomimetic Self-Adhesive Structures for Wearable Sensors

  • Feihu Chen,
  • Liuyang Han,
  • Ying Dong and
  • Xiaohao Wang

20 June 2022

Inspired by the adhesion ability of various organisms in nature, the research of biomimetic adhesion has shown a promising application prospect in fields such as manipulators, climbing robots and wearable medical devices. In order to achieve effectiv...

(This article belongs to the Section Biosensor Materials)
  • Article
  • Open Access
4 Citations
3,167 Views
10 Pages

13 October 2021

We propose a stacked dual-band quantum well infrared photodetector (QWIP) integrated with a double-layer gold disk. Two 10-period quantum wells (QW) operating at different wavelengths are stacked together, and gold nano-disks are integrated on their...

(This article belongs to the Special Issue State-of-the-Art Nanophotonics Materials and Devices in China)