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157 Results Found

  • Article
  • Open Access
9 Citations
3,500 Views
11 Pages

Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial

  • Tammam Abboud,
  • Thomas Asendorf,
  • Jutta Heinrich,
  • Katharina Faust,
  • Sandro M. Krieg,
  • Kathleen Seidel,
  • Dorothee Mielke,
  • Cordola Matthies,
  • Florian Ringel and
  • Andrea Szelényi
  • + 1 author

Background: Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there...

  • Article
  • Open Access
7 Citations
2,575 Views
12 Pages

Effect of Single Session of Anodal M1 Transcranial Direct Current Stimulation—TDCS—On Cortical Hemodynamic Activity: A Pilot Study in Fibromyalgia

  • Marianna La Rocca,
  • Livio Clemente,
  • Eleonora Gentile,
  • Katia Ricci,
  • Marianna Delussi and
  • Marina de Tommaso

18 November 2022

Transcranial direct current stimulation (TDCS) on the primary motor cortex (M1) has been reported to be effective in fibromyalgia (FM). Our previous works have shown hypometabolism of motor networks in FM using Functional Near Infrared Spectroscopy (...

  • Article
  • Open Access
7 Citations
3,547 Views
14 Pages

Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study

  • Sofia Straudi,
  • Annibale Antonioni,
  • Andrea Baroni,
  • Valentina Bonsangue,
  • Susanna Lavezzi,
  • Giacomo Koch,
  • Veronica Tisato,
  • Nicole Ziliotto,
  • Nino Basaglia and
  • Nicola Lamberti
  • + 2 authors

24 December 2023

Disorders of consciousness (DoC) due to severe traumatic brain injury (TBI) are associated with severe disability and an alteration of cortical activation, angiogenesis, and inflammation, which are crucial elements for behavioural recovery. This expl...

  • Review
  • Open Access
15 Citations
5,041 Views
25 Pages

22 March 2022

The infiltrative character of supratentorial lower grade glioma makes it possible for eloquent neural pathways to remain within tumoural tissue, which renders complete surgical resection challenging. Neuromodulation-Induced Cortical Prehabilitation (...

  • Review
  • Open Access
86 Citations
12,303 Views
18 Pages

A Review of Neurostimulation for Epilepsy in Pediatrics

  • Keith Starnes,
  • Kai Miller,
  • Lily Wong-Kisiel and
  • Brian Nils Lundstrom

18 October 2019

Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric...

  • Review
  • Open Access
19 Citations
18,765 Views
11 Pages

Are We Right about the Right TPJ? A Review of Brain Stimulation and Social Cognition in the Right Temporal Parietal Junction

  • Nathira Ahmad,
  • Samantha Zorns,
  • Katherine Chavarria,
  • Janet Brenya,
  • Aleksandra Janowska and
  • Julian Paul Keenan

20 November 2021

In the past decade, the functional role of the TPJ (Temporal Parietal Junction) has become more evident in terms of its contribution to social cognition. Studies have revealed the TPJ as a ‘distinguisher’ of self and other with research f...

  • Case Report
  • Open Access
2 Citations
4,264 Views
10 Pages

19 February 2024

Background: Vestibular migraine (VM) is common migraine that occurs in patients with dizziness. Vestibular rehabilitation for managing VM generally remains unclear. Recently, it has been reported that transcranial direct current stimulation (tDCS) ha...

  • Review
  • Open Access
13 Citations
7,326 Views
12 Pages

The Insula: A Stimulating Island of the Brain

  • Inès Rachidi,
  • Lorella Minotti,
  • Guillaume Martin,
  • Dominique Hoffmann,
  • Julien Bastin,
  • Olivier David and
  • Philippe Kahane

19 November 2021

Direct cortical stimulation (DCS) in epilepsy surgery patients has a long history of functional brain mapping and seizure triggering. Here, we review its findings when applied to the insula in order to map the insular functions, evaluate its local an...

  • Article
  • Open Access
3 Citations
4,072 Views
13 Pages

A Novel Language Paradigm for Intraoperative Language Mapping: Feasibility and Evaluation

  • Katharina Rosengarth,
  • Delin Pai,
  • Frank Dodoo-Schittko,
  • Katharina Hense,
  • Teele Tamm,
  • Christian Ott,
  • Ralf Lürding,
  • Elisabeth Bumes,
  • Mark W Greenlee and
  • Christian Doenitz
  • + 2 authors

8 February 2021

(1) Background—Mapping language using direct cortical stimulation (DCS) during an awake craniotomy is difficult without using more than one language paradigm that particularly follows the demand of DCS by not exceeding the assessment time of 4 s to p...

  • Review
  • Open Access
13 Citations
9,913 Views
21 Pages

Neurological diseases severely affect the quality of life of patients. Although existing treatments including rehabilitative therapy aim to facilitate the recovery of motor function, achieving complete recovery remains a challenge. In recent years, r...

  • Article
  • Open Access
1,525 Views
17 Pages

The Influence of Transcranial Alternating Current Stimulation on the Excitability of the Unstimulated Contralateral Primary Motor Cortex

  • Erik W. Wilkins,
  • Richard J. Young,
  • Ryder Davidson,
  • Reese Krider,
  • George Alhwayek,
  • Jonathan A. Park,
  • Armaan C. Parikh,
  • Zachary A. Riley and
  • Brach Poston

Objectives: Transcranial alternating current stimulation (tACS) can enhance primary motor cortex (M1) excitability and improve motor skill when delivered unilaterally to the dominant hemisphere. However, the impact of tACS on contralateral M1 excitab...

  • Article
  • Open Access
2 Citations
1,726 Views
17 Pages

Non-Dominant Hemisphere Excitability Is Unaffected during and after Transcranial Direct Current Stimulation of the Dominant Hemisphere

  • Erik W. Wilkins,
  • Richard J. Young,
  • Daniel Houston,
  • Eric Kawana,
  • Edgar Lopez Mora,
  • Meghana S. Sunkara,
  • Zachary A. Riley and
  • Brach Poston

Transcranial direct current stimulation (tDCS) increases primary motor cortex (M1) excitability and improves motor performance when applied unilaterally to the dominant hemisphere. However, the influence of tDCS on contralateral M1 excitability both...

  • Article
  • Open Access
10 Citations
3,533 Views
10 Pages

6 October 2021

The timing of transcranial direct current stimulation (tDCS) is essential for enhancing motor skill learning. Previously, tDCS, before or concurrently, with motor training was evaluated in healthy volunteers or elderly patients, but the optimal timin...

  • Review
  • Open Access
32 Citations
11,767 Views
23 Pages

Intraoperative Neurophysiological Monitoring in Neurosurgery

  • Giusy Guzzi,
  • Riccardo Antonio Ricciuti,
  • Attilio Della Torre,
  • Erica Lo Turco,
  • Angelo Lavano,
  • Federico Longhini and
  • Domenico La Torre

17 May 2024

Intraoperative neurophysiological monitoring (IONM) is a crucial advancement in neurosurgery, enhancing procedural safety and precision. This technique involves continuous real-time assessment of neurophysiological signals, aiding surgeons in timely...

  • Article
  • Open Access
9 Citations
4,632 Views
16 Pages

Safety of Special Waveform of Transcranial Electrical Stimulation (TES): In Vivo Assessment

  • Muhammad Adeel,
  • Chun-Ching Chen,
  • Bor-Shing Lin,
  • Hung-Chou Chen,
  • Jian-Chiun Liou,
  • Yu-Ting Li and
  • Chih-Wei Peng

Intermittent theta burst (iTBS) powered by direct current stimulation (DCS) can safely be applied transcranially to induce neuroplasticity in the human and animal brain cortex. tDCS-iTBS is a special waveform that is used by very few studies, and its...

  • Article
  • Open Access
2,488 Views
14 Pages

Background: Stroke is a major cause of disability worldwide. Upper limb impairment is prevalent after stroke. One of the post-stroke manifestations is impaired grip force directional control contributing to diminished abilities to grip and manipulate...

  • Case Report
  • Open Access
3 Citations
2,002 Views
20 Pages

Bidirectional and Cross-Hemispheric Modulations of Face-Selective Neural Activity Induced by Electrical Stimulation within the Human Cortical Face Network

  • Luna Angelini,
  • Corentin Jacques,
  • Louis Maillard,
  • Sophie Colnat-Coulbois,
  • Bruno Rossion and
  • Jacques Jonas

6 September 2024

A major scientific objective of cognitive neuroscience is to define cortico-cortical functional connections supporting cognitive functions. Here, we use an original approach combining frequency-tagging and direct electrical stimulation (DES) to test...

  • Proceeding Paper
  • Open Access
606 Views
6 Pages

Cortical Dynamics of Phosphene Perception: A Study Using EEG Signals

  • Fernando Daniel Farfán,
  • Fabrizio Grani,
  • Leili Soo,
  • Cristina Soto-Sanchez and
  • Eduardo Fernández

19 November 2025

The electrical stimulation of the primary occipital cortex can evoke luminous perceptions known as phosphenes, forming the basis for cortical visual prostheses for blind individuals. In this study, cortical dynamics during phosphene perception were i...

  • Article
  • Open Access
4 Citations
3,079 Views
13 Pages

1 June 2022

Peripheral nerve injury induces cortical remapping that can lead to sensory complications. There is evidence that inhibitory interneurons play a role in this process, but the exact mechanism remains unclear. Glutamate decarboxylase-1 (GAD1) is a prot...

  • Article
  • Open Access
9 Citations
4,761 Views
13 Pages

10 March 2022

In this study, the effective application of high-definition transcranial direct current stimulation (HD-tDCS) based on the whole brain hemodynamic response in stroke patients was investigated using functional near-infrared spectroscopy (fNIRS). The i...

  • Review
  • Open Access
42 Citations
8,561 Views
14 Pages

Transcranial Current Stimulations (tCSs) are non-invasive brain stimulation techniques which modulate cortical excitability and spontaneous brain activity by the application of weak electric currents through the scalp, in a safe, economic, and well-t...

  • Review
  • Open Access
8 Citations
5,245 Views
11 Pages

Relationship between Non-Invasive Brain Stimulation and Autonomic Nervous System

  • Giovanni Messina,
  • Antonietta Monda,
  • Antonietta Messina,
  • Girolamo Di Maio,
  • Vincenzo Monda,
  • Pierpaolo Limone,
  • Anna Dipace,
  • Marcellino Monda,
  • Rita Polito and
  • Fiorenzo Moscatelli

Non-invasive brain stimulation (NIBS) approaches have seen a rise in utilization in both clinical and basic neuroscience in recent years. Here, we concentrate on the two methods that have received the greatest research: transcranial direct current st...

  • Article
  • Open Access
6 Citations
3,251 Views
21 Pages

Therapeutic electrical stimulation, such as transcranial cortical stimulation and peripheral somatosensory stimulation, is used to improve motor function in patients with stroke. We hypothesized that these stimulations exert neuroprotective effects d...

  • Review
  • Open Access
2,997 Views
23 Pages

Brainstem Stroke and Dysphagia Treatment: A Narrative Review on the Role of Neuromodulation, Skill-Based Swallowing Training and Transient Receptor Potential Agonists

  • Ivy Cheng,
  • Wan-Qi Li,
  • Shaheen Hamdy,
  • Emilia Michou,
  • Maggie-Lee Huckabee,
  • Noemí Tomsen,
  • Pere Clavé and
  • Rainer Dziewas

12 November 2025

Swallowing is mediated by the central nervous system, including cortical and subcortical structures, the cerebellum, and the brainstem. The brainstem contains the swallowing centre that is crucial for initiating and coordinating swallowing. Consequen...

  • Article
  • Open Access
6 Citations
3,214 Views
20 Pages

Transcranial electrical brain stimulation techniques like transcranial direct current (tDCS) and transcranial alternating current (tACS) have emerged as potential tools for treating neurological diseases by modulating cortical excitability. These tec...

  • Article
  • Open Access
7 Citations
3,846 Views
16 Pages

17 February 2022

Transcutaneous spinal cord stimulation (tSCS) can improve upper-limb motor function after spinal cord injury. A number of studies have attempted to deduce the corticospinal mechanisms which are modulated following tSCS, with many relying on transcran...

  • Article
  • Open Access
2 Citations
1,772 Views
15 Pages

Cross-Task Differences in Frontocentral Cortical Activations for Dynamic Balance in Neurotypical Adults

  • Robert D. Magruder,
  • Komal K. Kukkar,
  • Jose L. Contreras-Vidal and
  • Pranav J. Parikh

15 October 2024

Although significant progress has been made in understanding the cortical correlates underlying balance control, these studies focused on a single task, limiting the ability to generalize the findings. Different balance tasks may elicit cortical acti...

  • Article
  • Open Access
11 Citations
3,866 Views
12 Pages

Suppression of Cortical Microtubule Reorientation and Stimulation of Cell Elongation in Arabidopsis Hypocotyls under Microgravity Conditions in Space

  • Shiho Kato,
  • Mana Murakami,
  • Ryo Saika,
  • Kouichi Soga,
  • Kazuyuki Wakabayashi,
  • Hirofumi Hashimoto,
  • Sachiko Yano,
  • Shohei Matsumoto,
  • Haruo Kasahara and
  • Takayuki Hoson
  • + 3 authors

8 February 2022

How microgravity in space influences plant cell growth is an important issue for plant cell biology as well as space biology. We investigated the role of cortical microtubules in the stimulation of elongation growth in Arabidopsis (Arabidopsis thalia...

  • Article
  • Open Access
3 Citations
2,368 Views
11 Pages

The Spatial Precision of Contextual Feedback Signals in Human V1

  • Lucy S. Petro,
  • Fraser W. Smith,
  • Clement Abbatecola and
  • Lars Muckli

20 July 2023

Neurons in the primary visual cortex (V1) receive sensory inputs that describe small, local regions of the visual scene and cortical feedback inputs from higher visual areas processing the global scene context. Investigating the spatial precision of...

  • Article
  • Open Access
12 Citations
4,599 Views
15 Pages

High-definition transcranial direct current stimulation (HD-tDCS) has recently been proposed as a tDCS approach that can be used on a specific cortical region without causing undesirable stimulation effects. In this uncontrolled pilot study, the cort...

  • Review
  • Open Access
4 Citations
2,908 Views
17 Pages

Since the spinal cord has traditionally been considered a bundle of long fibers connecting the brain to all parts of the body, the study of its role has long been limited to peripheral sensory and motor control. However, in recent years, new studies...

  • Review
  • Open Access
35 Citations
6,572 Views
16 Pages

The so-called cortical silent period (CSP) refers to the temporary interruption of electromyographic signal from a muscle following a motor-evoked potential (MEP) triggered by transcranial magnetic stimulation (TMS) over the primary motor cortex (M1)...

  • Article
  • Open Access
21 Citations
4,690 Views
24 Pages

28 February 2021

Transcranial direct current stimulation (tDCS) may enhance speech and language treatment (SLT) for stroke survivors with aphasia; however, to date, there is no standard protocol for the application of tDCS in post-stroke aphasia. We explored the safe...

  • Article
  • Open Access
19 Citations
4,863 Views
14 Pages

The Effect of Coil Orientation on the Stimulation of the Pre–Supplementary Motor Area: A Combined TMS and EEG Study

  • Elias P. Casula,
  • Giorgio Leodori,
  • Jaime Ibáñez,
  • Alberto Benussi,
  • Vishal Rawji,
  • Sara Tremblay,
  • Anna Latorre,
  • John C. Rothwell and
  • Lorenzo Rocchi

6 October 2022

Studies using transcranial magnetic stimulation (TMS) have demonstrated the importance of direction and intensity of the applied current when the primary motor cortex (M1) is targeted. By varying these, it is possible to stimulate different subsets o...

  • Article
  • Open Access
5 Citations
3,056 Views
14 Pages

Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation

  • Giuditta Gambino,
  • Filippo Brighina,
  • Mario Allegra,
  • Maurizio Marrale,
  • Giorgio Collura,
  • Cesare Gagliardo,
  • Alessandro Attanzio,
  • Luisa Tesoriere,
  • Danila Di Majo and
  • Giuseppe Giglia
  • + 2 authors

20 November 2022

Indicaxanthin (IX) from Opuntia Ficus Indica (OFI) has been shown to exert numerous biological effects both in vitro and in vivo, such as antioxidant, anti-inflammatory, neuro-modulatory activity in rodent models. Our goal was to investigate the even...

  • Systematic Review
  • Open Access
13 Citations
4,604 Views
15 Pages

25 December 2023

Transcranial direct current stimulation (tDCS) has been increasingly applied in fibromyalgia (FM) to reduce pain and fatigue. While results are promising, observed effects are variable, and there are questions about optimal stimulation parameters suc...

  • Article
  • Open Access
2 Citations
1,924 Views
13 Pages

A Novel Intraoperative Mapping Device Detects the Thermodynamic Response Function

  • Michael Iorga,
  • Nils Schneider,
  • Jaden Cho,
  • Matthew C. Tate and
  • Todd B. Parrish

Functional activation leads to an increase in local brain temperature via an increase in local perfusion. In the intraoperative setting, these cortical surface temperature fluctuations may be imaged using infrared thermography such that the activated...

  • Opinion
  • Open Access
7 Citations
4,786 Views
9 Pages

14 January 2023

In the decade since its debut, the Mesocircuit Hypothesis (MH) has provided researchers a scaffolding for interpreting their findings by associating subcortical-cortical dysfunction with the loss and recovery of consciousness following severe brain i...

  • Article
  • Open Access
28 Citations
8,404 Views
16 Pages

Remote-Controlled Fully Implantable Neural Stimulator for Freely Moving Small Animal

  • Seunghyeon Yun,
  • Chin Su Koh,
  • Joonsoo Jeong,
  • Jungmin Seo,
  • Seung-Hee Ahn,
  • Gwang Jin Choi,
  • Shinyong Shim,
  • Jaewoo Shin,
  • Hyun Ho Jung and
  • Sung June Kim
  • + 1 author

The application of a neural stimulator to small animals is highly desired for the investigation of electrophysiological studies and development of neuroprosthetic devices. For this purpose, it is essential for the device to be implemented with the ca...

  • Study Protocol
  • Open Access
12 Citations
5,796 Views
18 Pages

Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement

  • Jovana Bjekić,
  • Marko Živanović,
  • Dunja Paunović,
  • Katarina Vulić,
  • Uroš Konstantinović and
  • Saša R. Filipović

Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain sti...

  • Review
  • Open Access
2 Citations
5,272 Views
17 Pages

Neuromodulation for Cannabis Use: A Scoping Review

  • Anthony Ngoy,
  • Victor M. Tang,
  • Kebin Xiao,
  • Daniel M. Blumberger,
  • Tony P. George,
  • Joshua L. Gowin,
  • Bernard Le Foll and
  • Matthew E. Sloan

This scoping review explores the use of neuromodulation techniques in individuals with cannabis use. Our goal was to determine whether cannabis use alters cortical excitation and inhibition in the context of neuromodulation and to determine whether n...

  • Article
  • Open Access
7 Citations
2,662 Views
13 Pages

Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique

  • Devika Rajashekar,
  • Jose Pedro Lavrador,
  • Prajwal Ghimire,
  • Hannah Keeble,
  • Lauren Harris,
  • Noemia Pereira,
  • Sabina Patel,
  • Ahmad Beyh,
  • Richard Gullan and
  • Francesco Vergani
  • + 2 authors

9 September 2022

Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated the use of awake surgery. When this is not feasible, asleep monitoring and mapping techniques should be used to...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,133 Views
18 Pages

20 October 2022

Neurostimulation-based therapeutic approaches are emerging as alternatives to pharmacological drugs, but need further development to optimize efficacy and reduce variability. Despite its key relevance to pain, the insular cortex has not been explored...

  • Article
  • Open Access
13 Citations
3,163 Views
13 Pages

Anodal-TDCS over Left-DLPFC Modulates Motor Cortex Excitability in Chronic Lower Back Pain

  • Emily J. Corti,
  • An T. Nguyen,
  • Welber Marinovic,
  • Natalie Gasson and
  • Andrea M. Loftus

2 December 2022

Chronic pain is associated with abnormal cortical excitability and increased pain intensity. Research investigating the potential for transcranial direct current stimulation (tDCS) to modulate motor cortex excitability and reduce pain in individuals...

  • Review
  • Open Access
3,179 Views
12 Pages

Transcranial magnetic stimulation coupled with electroencephalography (TMS-EEG) is a novel technique to investigate cortical physiology in health and disease. The cerebellum has recently gained attention as a possible new hotspot in the field of TMS-...

  • Review
  • Open Access
102 Citations
14,235 Views
10 Pages

Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is...

  • Article
  • Open Access
2,438 Views
12 Pages

Does tDCS Enhance Complex Motor Skill Acquisition? Evidence from a Golf-Putting Task

  • Virginia Lopez-Alonso,
  • Gabriel López-Bermúdez,
  • Jeffrey Cayaban Pagaduan and
  • Jose Andrés Sánchez-Molina

10 July 2025

Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions—anodal stimulation over th...

  • Article
  • Open Access
4 Citations
3,809 Views
21 Pages

26 March 2022

Schizophrenia is a psychotic disease that develops progressively over years with a transition from prodromal to psychotic state associated with a disruption in brain activity. Transcranial Direct Current Stimulation (tDCS), known to alleviate pharmac...

  • Article
  • Open Access
2 Citations
2,464 Views
13 Pages

Preoperative Cortical Mapping for Brain Tumor Surgery Using Navigated Transcranial Stimulation: Analysis of Accuracy

  • Wellingson Silva Paiva,
  • Erich Talamoni Fonoff,
  • Rhuann Pontes dos Santos Silva,
  • Lucas Schiavao,
  • André Russowsky Brunoni,
  • César Cimonari de Almeida and
  • Carlos Carlotti Júnior

28 August 2024

Transcranial magnetic stimulation (TMS) represents a distinctive technique for non-invasive brain stimulation. Recent advancements in image processing have enabled the enhancement of TMS by integrating magnetic resonance imaging (MRI) modalities with...

  • Review
  • Open Access
15 Citations
3,594 Views
15 Pages

29 November 2022

Non-invasive brain stimulation (NIBS) has emerged as one of the methods implemented in stroke rehabilitation. Cerebellar stimulation has gained research interest as an alternative strategy to cortical stimulation, based on the role of the cerebellum...

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