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Transcranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder?

Department of Clinical Psychiatry, CIC-1431 INSERM, CHU de Besançon, EA Neurosciences, University Bourgogne Franche-Comte, FondaMental Foundation, 94000 Creteil, France
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(5), 81;
Received: 7 March 2018 / Revised: 19 April 2018 / Accepted: 3 May 2018 / Published: 6 May 2018
(This article belongs to the Special Issue New Research in Obsessive-Compulsive Disorder and Major Depression)
PDF [265 KB, uploaded 21 January 2019]


Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is to summarize the current status of knowledge regarding tDCS application in MDD. Methods: In this review, we searched for articles published in PubMed/MEDLINE from the earliest available date to February 2018 that explored clinical and cognitive effects of tDCS in MDD. Results: Despite differences in design and stimulation parameters, the examined studies indicated beneficial effects of tDCS for MDD. These preliminary results, the non-invasiveness of tDCS, and its good tolerability support the need for further research on this technique. Conclusions: tDCS constitutes a promising therapeutic alternative for patients with MDD, but its place in the therapeutic armamentarium remains to be determined. View Full-Text
Keywords: transcranial direct current stimulation; depression; cognition transcranial direct current stimulation; depression; cognition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bennabi, D.; Haffen, E. Transcranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder? Brain Sci. 2018, 8, 81.

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