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Article

Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

1
Department of Health Sciences and Technology, The Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea
2
Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
3
Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea
4
Department of Medical Device Management & Research, Department of Digital Health, The Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Ulf D. Kahlert
J. Pers. Med. 2022, 12(3), 432; https://doi.org/10.3390/jpm12030432
Received: 24 December 2021 / Revised: 28 February 2022 / Accepted: 8 March 2022 / Published: 10 March 2022
In this study, the effective application of high-definition transcranial direct current stimulation (HD-tDCS) based on the whole brain hemodynamic response in stroke patients was investigated using functional near-infrared spectroscopy (fNIRS). The intrahemispheric and interhemispheric synchronization and cortical activity based on the time during 1 mA HD-tDCS were examined in 26 chronic cerebrovascular disease patients. At the beginning of HD-tDCS, the synchronization and brain activity in the whole brain increased rapidly and decreased after 5 min. In the middle of tDCS, the synchronization began to increase again, and strong synchronic connections were formed around the desired stimulation area. After tDCS, strong cortical activation was observed in the stimulation area, indicating that the baseline of the oxyhemoglobin (HbO) signal increased in the desired stimulation area. Therefore, the results of this study indicate that HD-tDCS can be applied efficiently to enhance the effect of tDCS. This stimulation method with tDCS can be explored clinically for more neurorehabilitation of patients with degenerative brain diseases. View Full-Text
Keywords: hemodynamic response; brain signal synchronization; HD-tDCS; fNIRS; stroke patients hemodynamic response; brain signal synchronization; HD-tDCS; fNIRS; stroke patients
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MDPI and ACS Style

Lee, G.; Lee, J.; Kim, J.; Kim, H.; Chang, W.H.; Kim, Y.-H. Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study. J. Pers. Med. 2022, 12, 432. https://doi.org/10.3390/jpm12030432

AMA Style

Lee G, Lee J, Kim J, Kim H, Chang WH, Kim Y-H. Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study. Journal of Personalized Medicine. 2022; 12(3):432. https://doi.org/10.3390/jpm12030432

Chicago/Turabian Style

Lee, Gihyoun, Jungsoo Lee, Jinuk Kim, Heegoo Kim, Won Hyuk Chang, and Yun-Hee Kim. 2022. "Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study" Journal of Personalized Medicine 12, no. 3: 432. https://doi.org/10.3390/jpm12030432

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