Synthetic DNA barcodes are double-stranded DNA molecules designed to carry recoverable information, information that can be used to represent and track objects and organisms. DNA barcodes offer robust, sensitive detection using standard amplification...
In the context of intelligent construction and building industrialization, assembly buildings face many challenges in quality management due to their special design and construction characteristics. Therefore, a comprehensive method for evaluating th...
DNA-templated self-assembly is an emerging strategy for generating functional supramolecular systems, which requires the identification of potent multi-point binding ligands. In this line, we recently showed that bis-functionalized guanidinium compo...
Problem: Existing Human–Robot Collaboration (HRC) allocators cannot react at a sub-second scale while accounting for worker fatigue. Objective: We designed a fatigue-aware combinatorial auction executed every 100 ms. Method: A human and a FANUC...
Assembly is the final process of manufacturing, and a good assembly plan reduces the effect of the tolerance generated in the early stages by the tolerance elimination. In the current assembly lines, the assemblers pick up the workpieces and install...
Background/objectives: Streptococcus agalactiae (or Group B Streptococcus, GBS) is a major cause of neonatal meningitis globally. There are 10 serotypes of GBS, which are distinguished by their capsular polysaccharide (CPS) structure, with serotypes...
The hierarchically directed assembly of multiple types of colloidal nano-objects on surfaces is of interest for developing disruptive applications combining their original properties. We propose herein a versatile, electrostatically driven strategy t...
This research explores the SL-Block system within an architecture framework by embracing building modularity, combinatorial design, topological interlocking, machine learning, and tactile sensor-based robotic assembly. The SL-Block, composed of S and...
Aiming at resolving the problem of low assembly accuracy and the difficulty of guaranteeing assembly quality of remanufactured parts, an optimization classification method for the assembly sequence of remanufactured parts based on different accuracy...
When studying polyethylenimine derivatives as nonviral vectors for gene delivery, among the important issues to be addressed are high toxicity, low transfection efficiency, and nucleic acid polyplex condensation. The molecular weight of polyethylenim...
Synthetic biology allows the re-engineering of biological systems and promotes the development of bioengineering to a whole new level, showing great potential in biomanufacturing. Here, in order to make the heterologous lycopene biosynthesis pathway...
The priming effect (PE) occurs when fresh organic matter (FOM) supplied to soil alters the rate of decomposition of older soil organic matter (SOM). The PE can be generated by different mechanisms driven by interactions between microorganisms with di...
A common problem in the analysis of biological systems is the combinatorial explosion that emerges from the complexity of multi-protein assemblies. Conventional formalisms, like differential equations, Boolean networks and Bayesian networks, are unsu...
Introduction. Many pharmacological properties of dipyridamole (DIP) are associated with its ability to inhibit phosphodiesterases (PDEs). Actually, DIP has interesting properties like antiviral for influenza, SARS-2 COVID-19, and herpesviruses. Our r...
Based on the flexible adjustment of the seven-wire, this study will assemble a new toughened seven-wire which is combined with a common single welding wire and the existing welding wire containing ductile alloy element (Ni element), and the microstru...
In the construction process of large cruise ships, there are numerous cabin components, and the number of assembly sequences will experience a “combinatorial explosion”, which will become a complex NP hard problem. This article proposes a...
Eukaryotic proteasomes harbor heteroheptameric α-rings, each composed of seven different but homologous subunits α1–α7, which are correctly assembled via interactions with assembly chaperones. The human proteasome α7 sub...
Non-small cell lung cancer (NSCLC) accounts about 80% of all lung cancers. More than two-thirds of NSCLC patients have inoperable, locally advanced or metastatic tumors. Non-toxic agents that synergistically potentiate cancer-killing activities of ch...
Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as...
Fluorescent self assembled monolayers (SAMs) on glass were previouslydeveloped in our group as new sensing materials for metal ions. These fluorescent SAMs arecomprised by fluorophores and small molecules sequentially deposited on a monolayer onglass...
While plant polyphenols possess a variety of biological properties, exploration of chemical diversity around them is still problematic. Here, an example of application of the Ugi multicomponent reaction to the combinatorial assembly of artificial, ye...
Poly(p-dioxanone) (PPDO) is crystallized with amorphous poly(p-vinyl phenol) (PVPh) and tannic acid (TA) as co-diluents to regulate and induce dendritic-ringed PPDO spherulites, with spoke- or sector-bands, aiming for convenience of analyses on inter...
Peptide monomers can either self-assemble with themselves enacting a solo-component assembly or they can co-assemble by interacting with other suitable partners to mediate peptide co-assembly. Peptide co-assemblies represent an innovative class of na...
Integrating multi-modal therapies into one platform could show great promise in overcoming the drawbacks of conventional single-modal therapy and achieving improved therapeutic efficacy in cancer. In this study, we prepared pheophorbide a (Pheo a)/ta...
Remarkable progress has been made to date in the discovery of material binding peptides and their utilization in nanotechnology, which has brought new challenges and opportunities. Nowadays phage display is a versatile tool, important for the selecti...
The nonribosomal peptide synthetase (NRPS) is a highly precise molecular assembly machinery for synthesizing structurally diverse peptides, which have broad medicinal applications. Withinthe NRPS, the condensation (C) domain is a core catalytic domai...
In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacte...
Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, and also in combinatorial approaches. Moreover, short peptides have relevance in cancer imaging or 3D cult...
The modification of implant devices with biocompatible coatings has become necessary as a consequence of premature loosening of prosthesis. This is caused mainly by chronic inflammation or allergies that are triggered by implant wear, production of a...
Diabetes poses a high risk for debilitating complications in neural tissues, regulating glucose uptake through insulin-dependent and predominantly insulin-independent pathways. Supramolecular nanostructures provide a flexible strategy for combinatori...
We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through...
Diabetes-related neuropathy is a debilitating condition that may be averted if it can be detected early. One possible way this can be achieved at low cost is to utilise peptides to detect C-peptide, a biomarker of diabetic neuropathy. This depends on...
Modular polyketide synthases (mPKSs) build functionalized polymeric chains, some of which have become blockbuster therapeutics. Organized into repeating clusters (modules) of independently-folding domains, these assembly-line-like megasynthases can b...
The flexible job shop scheduling problem is a typical and complex combinatorial optimization problem. In recent years, the assembly problem in job shop scheduling problems has been widely studied. However, most of the studies ignore the learning effe...
The growing emphasis on sustainable manufacturing has motivated the integration of environmental and social factors into traditional assembly line balancing problems (ALBPs). This study introduces a Sustainable Mixed-Model Assembly Line Balancing Pro...
Ilicicolin H is a broad-spectrum antifungal agent targeting mitochondrial cytochrome bc1 reductase. Unfortunately, ilicicolin H shows reduced activities in vivo. Here, we report our effort on the identification of ilicicolin H biosynthetic gene clust...
Chrysomycin A is one of the most promising therapeutic candidates for treating infections caused by multidrug-resistant Gram-positive bacteria. By hybridizing next-step generation (Illumina) and third-generation (PacBio) sequencing technologies, a hi...
Ubiquitination is controlled by a series of E1, E2, and E3 enzymes that can ligate ubiquitin to cellular proteins and dictate the turnover of a substrate and the outcome of signalling events such as DNA damage repair and cell cycle. This process is c...
In configuration design, the task is to compose a system out of a set of predefined, modu-lar building blocks assembled by defined interfaces. Product configuration systems, both with or without integration of geometric models, implement reasoning te...
Aperiodic tessellations of polykite unitiles, such as hats and turtles, and the recently introduced hares, red squirrels, and gray squirrels, have attracted significant interest due to their structural and combinatorial properties. Our primary object...
Polymersomes, self-assembled nanoparticles composed of amphiphilic block copolymers, have emerged as promising versatile nanovesicles with various applications, such as drug delivery, medical imaging, and diagnostics. The integration of click chemist...
The Distributed No-Wait Flow Shop Scheduling Problem (DNWFSP) arises in various manufacturing contexts, such as chemical production and electronic assembly, where strict no-wait constraints and multi-factory coordination are required. Solving the DNW...
Rare sugars possess potential applications as low-calorie sweeteners, especially for anti-obesity and anti-diabetes. In this study, a fermentation biosystem based on the “DHAP-dependent aldolases strategy” was established for D-allulose a...
In this work, electrospun nanofiber membranes are investigated as separators for lithium batteries. Membrane consisting of polyacrylonitrile-polycaprolactone mixtures were produced following a combinatorial approach inspired by design of experiments...
Background: Interleukin-15 (IL-15) stimulates the proliferation of natural killer cells or T cells, which, in combination with photodynamic therapy (PDT), has emerged as an effective strategy for cancer photoimmunotherapy. Instead of direct cytokine...
In many plant–pathogen interactions, the host resistance is governed by a combinatorial action of multiple genes termed as quantitative disease resistance (QDR). Three decades of genetic research on economically important interaction of chickpea (Cic...
Glioblastoma multiforme (GBM) is the most aggressive and commonly diagnosed brain cancer and is highly resistant to routine chemotherapeutic drugs. The present study involves the synthesis of Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel, loaded with cur...
Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedde...
Top-down tissue engineering aims to produce functional tissues using biomaterials as scaffolds, thus providing cues for cell proliferation and differentiation. Conversely, the bottom-up approach aims to precondition cells to form modular tissues unit...
In recent years, due to the advantages of high construction efficiency and less environmental pollution, prefabricated housing has been of increasing interest and vigorously promoted. However at present, most prefabricated houses simply pursue an inc...
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