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Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies

1
Proxima Concepts Limited, c/o London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
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Bone Medical Limited, P.O. Box 154, Nedlands, Perth, WA, 6909, Australia
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Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia
5
The School of Pharmacy, The University of Queensland, Brisbane, QLD, 4072, Australia
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(3), 3427-3441; https://doi.org/10.3390/molecules18033427
Received: 20 January 2013 / Revised: 8 March 2013 / Accepted: 11 March 2013 / Published: 14 March 2013
(This article belongs to the Section Medicinal Chemistry)
We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner. View Full-Text
Keywords: mixed micelles; combinatorial biology; drug discovery; lipoamino acids; supramolecular aggregates; amphiphilic constructs; lipopetides mixed micelles; combinatorial biology; drug discovery; lipoamino acids; supramolecular aggregates; amphiphilic constructs; lipopetides
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New, R.; Bansal, G.S.; Bogus, M.; Zajkowska, K.; Rickelt, S.; Toth, I. Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies. Molecules 2013, 18, 3427-3441.

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