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46 Results Found

  • Article
  • Open Access
8 Citations
4,451 Views
21 Pages

Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)

  • Brianna D. Young,
  • Wenbo Yu,
  • Darex J. Vera Rodríguez,
  • Kristen M. Varney,
  • Alexander D. MacKerell and
  • David J. Weber

13 January 2021

S100B, a biomarker of malignant melanoma, interacts with the p53 protein and diminishes its tumor suppressor function, which makes this S100 family member a promising therapeutic target for treating malignant melanoma. However, it is a challenge to d...

  • Article
  • Open Access
1 Citations
2,142 Views
12 Pages

21 May 2023

The stress-induced leakage current (SILC) degradation of partially depleted silicon in insulator (PDSOI) devices under constant voltage stress (CVS) was studied. Firstly, the behaviors of threshold voltage degradation and SILC degradation of H-gate P...

  • Article
  • Open Access
9 Citations
5,278 Views
17 Pages

21 June 2022

The human ether-a-go-go-related gene (hERG) potassium channel is a well-known contributor to drug-induced cardiotoxicity and therefore is an extremely important target when performing safety assessments of drug candidates. Ligand-based approaches in...

  • Article
  • Open Access
22 Citations
11,333 Views
21 Pages

It is sometimes observed and frequently assumed that top incomes in household surveys worldwide are poorly measured and that this problem biases the measurement of income inequality. This paper tests this assumption and compares the performance of re...

  • Article
  • Open Access
4 Citations
4,660 Views
14 Pages

6 February 2021

The Spanish public retirement pension system, the same as that of many European countries, faces two important risks in the long term. On the one hand, the sustainability of the current pay-as-you-go system and, on the other hand, the ability to main...

  • Article
  • Open Access
6 Citations
2,944 Views
11 Pages

Objectives: To explore whether the influence of a partner’s socioeconomic status (SES) on health has an additive or a combined effect with the ego’s SES. Methods: With data on 4533 middle-aged (30–59) different-sex couples from the...

  • Article
  • Open Access
1,481 Views
10 Pages

Unmet Needs for Dental Care Before and During the COVID-19 Pandemic in Greece: A Cross-Sectional Study

  • Christos Ntais,
  • Athina Charalampaki,
  • Michael A. Talias,
  • Nikolaos Kontodimopoulos and
  • John Fanourgiakis

15 November 2024

Background/Objectives: Unmet dental needs involve cases wherein someone needed dental care and did not receive it. Published data on unmet dental needs are limited. This cross-sectional study investigates unmet dental needs in Greece before and durin...

  • Article
  • Open Access
12 Citations
5,037 Views
15 Pages

The Impacts of Tourism Stays on Residents’ Self-Reported Health: A Pan-European Analysis on the Role of Age and Urbanization Level

  • Anna Bornioli,
  • Susan J. Vermeulen,
  • Jeroen van Haaren,
  • Riccardo Valente and
  • Giuliano Mingardo

20 January 2022

Understanding the impacts of tourism on the quality of life of residents is a priority for the sustainable tourism agenda, and is especially relevant to the COVID-19 recovery period. However, the evidence is poor, and it is not clear whether the outc...

  • Article
  • Open Access
14 Citations
5,431 Views
19 Pages

Background: The mixed empirical evidence about employment conditions (i.e., permanent vs. temporary job, full-time vs. part-time job) as well as unemployment has motivated the development of conceptual models with the aim of assessing the pathways le...

  • Article
  • Open Access
9 Citations
1,262 Views
23 Pages

14 December 2024

Research on household energy poverty is crucial for addressing basic human needs, highlighting the importance of conducting studies across different countries. This study examines energy poverty in the Visegrad Group countries using 2022 data from th...

  • Article
  • Open Access
10 Citations
3,743 Views
17 Pages

30 May 2022

Measures of inequality can be used to illustrate inequality between and within groups, but the choice of the appropriate measure can have different implications. This study focused on the Mean Logarithmic Deviation, the measure proposed by Theil and...

  • Article
  • Open Access
10 Citations
7,699 Views
20 Pages

The cohesiveness of constituent nations in a confederation such as the Eurozone depends on their equally shared experiences. In terms of household incomes, commonality of distribution across those constituent nations with that of the Eurozone as an e...

  • Article
  • Open Access
1,535 Views
24 Pages

1 November 2024

Position-dependent periodic disturbances often limit the accuracy and smoothness of the positional motion of permanent magnet synchronous motor (PMSM)-driven rotary machines. Because the period of these disturbances varies with the motion velocity of...

  • Article
  • Open Access
8 Citations
3,566 Views
16 Pages

Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype

  • Shorouk Makhlouf,
  • Nehal M. Atallah,
  • Susanna Polotto,
  • Andrew H. S. Lee,
  • Andrew R. Green and
  • Emad A. Rakha

16 May 2024

Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse gro...

  • Article
  • Open Access
6 Citations
2,452 Views
11 Pages

Prevalence of Lyme Carditis in Patients with Atrioventricular Blocks

  • Krzysztof A. Kaczmarek,
  • Katarzyna Szwabe,
  • Irmina Urbanek,
  • Pawel Ptaszynski,
  • Aleksander Strzelecki,
  • Jerzy K. Wranicz and
  • Iwona Cygankiewicz

Infections with Borrelia may cause cardiac conduction system abnormalities, including atrioventricular blocks (AVBs). Therefore, we aimed to identify patients in whom Lyme carditis (LC) could be considered as the initial diagnosis among consecutive s...

  • Review
  • Open Access
11 Citations
3,286 Views
35 Pages

29 January 2021

X-ray analysis cannot provide quantitative estimates of the relative contribution of non-specific, specific, strong, and weak contacts of extended DNA molecules to their total affinity for enzymes and proteins. The interaction of different enzymes an...

  • Article
  • Open Access
22 Citations
5,343 Views
13 Pages

Fuzzy Measures of Multidimensional Poverty in the Mediterranean Area: A Focus on Financial Dimension

  • Martina Ciani,
  • Francesca Gagliardi,
  • Samuele Riccarelli and
  • Gianni Betti

28 December 2018

The main scope of the paper is to adopt a fuzzy sets approach for the measurement of multidimensional poverty over a period of eight years, from 2007 to 2015, which takes into account the effect of the 2008 economic and financial crisis. In particula...

  • Communication
  • Open Access
30 Citations
10,097 Views
5 Pages

22 September 2018

Lyme carditis (LC) is a manifestation of the early disseminated stage of Lyme disease and often presents as high-degree atrioventricular (AV) block. High-degree AV block in LC can be treated with antibiotics, usually resolving with a highly favorable...

  • Article
  • Open Access
2,021 Views
12 Pages

The Heavy Burden of “Dependent Children”: An Italian Story

  • Gianni Betti,
  • Francesca Gagliardi and
  • Laura Neri

3 September 2021

This paper analyses multidimensional fuzzy monetary and non-monetary deprivation in households with children by using two different definitions: households with children under 14 years old, and the EU definition of households with dependent children....

  • Article
  • Open Access
11 Citations
3,522 Views
12 Pages

5 October 2020

Over the last few years, there has been increased interest in compiling poverty indicators for children, as well as in providing uncertainty measures that are associated with point estimates. In this paper, we provide point, variance, and interval co...

  • Article
  • Open Access
7 Citations
3,529 Views
17 Pages

3 November 2022

Housing quality is a well-established determinant for health and its relevance has been increasing in the context of sustainable development. Prior research has emphasized the importance of adequate housing for the health and comfort of householders....

  • Article
  • Open Access
5 Citations
3,288 Views
23 Pages

Financial Burden of Medical Care, Dental Care, and Medicines among Older-Aged Population in Slovenia, Serbia, and Croatia

  • Katarina Vojvodic,
  • Zorica Terzic-Supic,
  • Jovana Todorovic,
  • Cristina Gagliardi,
  • Milena Santric-Milicevic and
  • Marina Popovic

The aim was to explore the factors associated with the financial burden (FB) of medical care, dental care, and medicines among older-aged people in Slovenia, Serbia, and Croatia using EU-SILC 2017. The highest frequency of FB of medical care and medi...

  • Article
  • Open Access
18 Citations
11,292 Views
16 Pages

Flat-Rate versus Progressive Taxation? An Impact Evaluation Study for the Case of Romania

  • Madalina Ecaterina Popescu,
  • Eva Militaru,
  • Larisa Stanila,
  • Maria Denisa Vasilescu and
  • Amalia Cristescu

14 November 2019

Taking into consideration the recent debates on adopting a progressive tax system over the flat-rate taxation, our paper aims to investigate the impact of a change in the current Romanian personal income tax policy system from the 10% flat-rate tax s...

  • Article
  • Open Access
3 Citations
2,647 Views
12 Pages

This study explores the relevance of economic factors (e.g., a household’s economic capacity and the prevailing economic context) to understand the relationship between the partnership status and the health of Spanish adult women and men (age 3...

  • Article
  • Open Access
1 Citations
2,075 Views
17 Pages

Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from Taenia solium Using Computational and Bioinformatics Tools

  • César Sánchez-Juárez,
  • Roberto Flores-López,
  • Lluvia de Carolina Sánchez-Pérez,
  • Ponciano García-Gutiérrez,
  • Lucía Jiménez,
  • Abraham Landa and
  • Rafael A. Zubillaga

25 December 2024

Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. Inhibiting GST activity can com...

  • Article
  • Open Access
4 Citations
3,911 Views
22 Pages

4 March 2024

The background of the study is the analysis of social expenditure efficiency in European countries over time. Terminological considerations leading from hedonism and eudaimonism to the concept of subjectively perceived well-being and the Easterlin pa...

  • Article
  • Open Access
6 Citations
5,460 Views
20 Pages

Assessing Minimum Wage Policy Implications upon Income Inequalities. The Case of Romania

  • Eva Militaru,
  • Madalina Ecaterina Popescu,
  • Amalia Cristescu and
  • Maria Denisa Vasilescu

Starting from the consideration that excessive income inequalities could hamper sustainable growth, our paper aims to evaluate the impact of the minimum wage policy upon wage and income distributions. Using the European Union Survey on Income and Liv...

  • Article
  • Open Access
4 Citations
3,573 Views
25 Pages

Assessing Efficiency of Public Poverty Policies in UE-28 with Linguistic Variables and Fuzzy Correlation Measures

  • Jorge de Andrés-Sánchez,
  • Angel Belzunegui-Eraso and
  • Francesc Valls-Fonayet

8 January 2021

The present study analyzes the efficiency of social expenditure by EU-28 countries within the period 2014–2018 to reduce poverty. The data are provided by programs European Union Statistics on Income and Living Conditions (EU-SILC) and European...

  • Article
  • Open Access
6 Citations
4,399 Views
21 Pages

The significant deterioration of economic prosperity in Greece during the economic crisis decreased patients’ ability to pay. Thus, the objective of this study is to determine the factors affecting healthcare affordability in Greece during an e...

  • Article
  • Open Access
9 Citations
2,892 Views
19 Pages

2 October 2020

Over the last years, there has been an increased interest in compiling poverty indicators as well as in providing uncertainty measures both at national and regional level. In this paper, we provide point and variance estimates of two widely used inco...

  • Article
  • Open Access
1 Citations
5,266 Views
32 Pages

19 January 2018

Background: The article investigates the phenomenon of economic insecurity from a feminist perspective, assessing the role of women’s labour market participation in predicting the phenomenon. It draws on the work of Trifiletti (1999) to analyse women...

  • Article
  • Open Access
1 Citations
4,923 Views
25 Pages

11 September 2024

Specific aspects and territorial characteristics of migration have been extensively studied, while the primary living conditions of foreigners have been less compared in-depth. Using data from the Labor Force Surveys and EU-Silc for the year 2019, re...

  • Article
  • Open Access
42 Citations
4,165 Views
17 Pages

lncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway

  • Hongxia Liu,
  • Wang Zheng,
  • Qianping Chen,
  • Yuchuan Zhou,
  • Yan Pan,
  • Jianghong Zhang,
  • Yang Bai and
  • Chunlin Shao

30 January 2021

Nasopharyngeal carcinoma (NPC) is one of the most frequent head and neck malignant tumors and is majorly treated by radiotherapy. However, radiation resistance remains a serious obstacle to the successful treatment of NPC. The aim of this study was t...

  • Article
  • Open Access
5 Citations
3,355 Views
25 Pages

13 February 2025

Quality of life (QoL) as a category, which is an overarching goal of sustainable development, dependent on many factors both objective and subjective, should be subjected to constant monitoring in various spatial, temporal and thematic arrangements....

  • Article
  • Open Access
5,225 Views
30 Pages

Poor Employment Conditions and Immigrant Health in Europe

  • Matthew D. Matsaganis,
  • Maria Petraki and
  • Dionysis Balourdos

25 December 2024

Building on the extant literature and utilizing data from the EU-SILC and the EU-LFS surveys conducted between 2009 and 2023, we empirically investigate the impact of poor employment conditions—associated with insecure or precarious employment&...

  • Article
  • Open Access
38 Citations
4,351 Views
10 Pages

Development of a 3D Printed Brain Model with Vasculature for Neurosurgical Procedure Visualisation and Training

  • Manuel Encarnacion Ramirez,
  • Issael Ramirez Pena,
  • Rossi E. Barrientos Castillo,
  • Albert Sufianov,
  • Evgeniy Goncharov,
  • Jose A. Soriano Sanchez,
  • Manuel Colome-Hidalgo,
  • Renat Nurmukhametov,
  • José Rafael Cerda Céspedes and
  • Nicola Montemurro

Background: Simulation-based techniques using three-dimensional models are gaining popularity in neurosurgical training. Most pre-existing models are expensive, so we felt a need to develop a real-life model using 3D printing technology to train in e...

  • Article
  • Open Access
16 Citations
9,397 Views
32 Pages

Comparison of Cost of Protection against Differential Power Analysis of Selected Authenticated Ciphers

  • William Diehl,
  • Abubakr Abdulgadir,
  • Farnoud Farahmand,
  • Jens-Peter Kaps and
  • Kris Gaj

Authenticated ciphers, which combine the cryptographic services of confidentiality, integrity, and authentication into one algorithmic construct, can potentially provide improved security and efficiencies in the processing of sensitive data. However,...

  • Article
  • Open Access
1,024 Views
22 Pages

Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors

  • Wenbo Yu,
  • Alexander D. MacKerell,
  • David J. Weber and
  • Jean-Pierre Raufman

17 September 2025

The proposed physiological roles of bile acids have expanded beyond the digestion of fats to encompass cell signaling via the activation of a variety of nuclear and plasma membrane receptors in multiple organ systems. The current in silico study was...

  • Article
  • Open Access
21 Citations
4,482 Views
18 Pages

22 December 2020

Energy poverty is high up on national and European Union policy agendas. A number of possible indicators to measure the issue have been identified in the literature, but comparable data with European coverage is scarce. The EU Commission thus propose...

  • Article
  • Open Access
14 Citations
1,423 Views
8 Pages

21 September 2017

Background and objective: The relationship between income and health in late life is well established, but the link between subjective financial wellbeing (SFW) and self-rated health (SRH) has been relatively ignored, especially among elderly in Euro...

  • Article
  • Open Access
3 Citations
12,650 Views
37 Pages

Effects of the Minimum Wage (MW) on Income Inequality: Systematic Review and Analysis of the Spanish Case

  • Manuela A. de Paz-Báñez,
  • Celia Sánchez-López and
  • María José Asensio-Coto

23 August 2024

The minimum wage has become a standard measure in the economic and social policies of countries all over the world. The primary objective of this measure is to guarantee that workers receive a minimum wage that allows them to lead a decent life, ther...

  • Article
  • Open Access
5 Citations
5,711 Views
28 Pages

19 April 2023

This multi-country article focuses particularly on homeownership among the young. After all, relying on European Union Statistics on Income and Living Conditions (EU-SILC) data in twelve European countries, we can see that in contrast to the aggregat...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,694 Views
25 Pages

13 June 2025

This paper investigates the dynamics of energy poverty across EU Member States from 2015 to 2023, a period characterized by economic recovery, the COVID-19 pandemic, and a significant energy crisis. Utilizing Eurostat EU-SILC data, the study analyzes...

  • Article
  • Open Access
6 Citations
2,393 Views
19 Pages

Potential Use of Wheat Straw, Grape Pomace, Olive Mill Wastewater and Cheese Whey in Mixed Formulations for Silage Production

  • Angela Gabriella D’Alessandro,
  • Roberta Savina Dibenedetto,
  • Ioannis Skoufos and
  • Giovanni Martemucci

5 September 2023

Two experiments were conducted to investigate the chemical and fermentative characteristics of by-product-mixed silages consisting of wheat straw (WS), grape pomace (GP), olive mill wastewater (OMWW) and cheese whey (CW) at 7, 30 and 90 days. The sil...

  • Article
  • Open Access
2 Citations
1,634 Views
18 Pages

Cardiovascular Risk Factors in Socioeconomically Disadvantaged Populations in a Suburb of the Largest City in Western Romania

  • Andreea Dumitrescu,
  • Gabriela Mut Vitcu,
  • Svetlana Stoica,
  • Septimiu Radu Susa and
  • Emil Robert Stoicescu

Background and Objectives: Cardiovascular disease (CVD) remains a major public health issue worldwide, disproportionately affecting socioeconomically disadvantaged populations due to the social determinants of health (SDOHs). In Western Romania, thes...

  • Article
  • Open Access
16 Citations
5,747 Views
22 Pages

23 February 2023

The semantic segmentation of remote sensing images is a significant research direction in digital image processing. The complex background environment, irregular size and shape of objects, and similar appearance of different categories of remote sens...