- Article
Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)
- Brianna D. Young,
- Wenbo Yu,
- Darex J. Vera Rodríguez,
- Kristen M. Varney,
- Alexander D. MacKerell and
- David J. Weber
S100B, a biomarker of malignant melanoma, interacts with the p53 protein and diminishes its tumor suppressor function, which makes this S100 family member a promising therapeutic target for treating malignant melanoma. However, it is a challenge to d...