160 Results Found

Pre-B-cell leukemia factor 1 (PBX1) is a transcription factor that plays a significant role in various physiological, developmental, and oncogenic processes in humans. The mechanisms and interactions of PBX1 in both solid and hematologic malignancies...

Objective: β-cell dysfunction and loss are major pathological determinants of impaired islet function and hyperglycemia in diabetes. Given the inability of current therapies to restore β-cell viability or glucose-responsive insulin secretio...

Non-small cell lung cancer (NSCLC) accounts for 85~90% of lung cancer cases, with a poor prognosis and a low 5-year survival rate. Sphingosine kinase-1 (SPHK1), a key enzyme in regulating sphingolipid metabolism, has been reported to be involved in t...

PBX3 is a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, members of which have extensive roles in early development and some adult processes. A number of features distinguish PBX3 from other PBX proteins, includi...

Childhood B-cell acute lymphoblastic leukemia (B-ALL) is a heterogeneous disease comprising multiple molecular subgroups with subtype-specific expression profiles. Recently, a new type of ncRNA, termed circular RNA (circRNA), has emerged as a promisi...

In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. HOX proteins execute their activity by exploiting a cooperative binding to PBX proteins and DNA. Therefore, an increase or decrease i...

IP-PBX have grown considerably in the telecoms and IT industries in recent times due to their low cost, high customizability, open source and hardware-independent nature. Unlike traditional PBX systems that are TDM-based and require a separate wired...

Proper control of the temporal onset of cellular differentiation is critical for regulating cell lineage decisions and morphogenesis during development. Pbx homeodomain transcription factors have emerged as important regulators of cellular differenti...

Material Point Method (MPM) mesoscale simulation was used to study the constitutive relation of a polymer bonded explosive (PBX) consisting of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and a fluorine polymer binder F₂₃₁₄. The stress-strain variatio...

PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and acts as a transcriptional cofactor of HOX proteins participating in several pathophysiological processes. Recent studies have revealed that the dysregulation of P...

3-Nitro−1,2,4-triazol−5-one (NTO) is an explosive with broad application prospects. To study the effect of NTO content on the properties of HMX-based cast-PBX (polymer bonded explosive), five different HMX/NTO-based cast-PBXs were prepare...

Tumor cells alter lipid metabolic pathways to meet their demands for energy and membrane biosynthesis. Despite its crucial role in tumor cell growth, survival, and metastasis, the mechanisms underlying tumor cell lipid metabolic reprogramming remain...

This paper presents a methodology for studying the level of network security of VoIP platforms. The methodology is designed for VoIP platforms where the voice and video traffic passes through and are processed by the VoIP server itself, rather than b...

In order to study the ignition process and response characteristics of cast polymer-bonded explosives (PBX) under the action of friction, HMX-based cast PBX explosives were used to carry out friction ignition experiments at a 90° swing angle and...

Members of the pre-B-cell leukemia transcription factor (PBX) family of homeoproteins are mainly known for their involvement in hematopoietic cell differentiation and in the development of leukemia. The four PBX proteins, PBX1, PBX2, PBX3 and PBX4, b...

Modern energetic materials (EMs) have many different civil applications. One of their most promising applications in civil engineering is explosive hardening, which facilitates the fast and cost-effective improvement of mechanical properties in the t...

The increasingly harsher and more complex international and European environmental legislation drives the current development of “greener” energetics materials and munitions. The aerospace and defense industries rely on extensive research...

Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in ML...

Background/Objectives: The HOX genes encode a family of homeodomain-containing transcription factors that have important roles in defining cell and tissue identity in embryonic development, but which also show deregulated expression in many cancers a...

Background: Genetic variants in Pre-B cell Leukemia Factor 1 (PBX1) transcription factor (TF) have been associated with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). This study aims to functionally characterize a novel missense varian...

Sexual development is a complex process relying on numerous genes. Disruptions in some of these genes are known to cause differences of sexual development (DSDs). Advances in genome sequencing allowed the discovery of new genes implicated in sexual d...

In this work, a hypothesis is studied as to whether different DoS attacks affect the parameters of voice and video streams, as well as performance, on three different VoIP platforms. This research is a continuation of a previous work, which studied t...

Binders mixed with explosives to form polymer-bonded explosives (PBXs) can reduce the sensitivity of the base explosive by improving interfacial interactions. The interface formed between the binder and matrix explosive also affects the thermal condu...

A nesting ubiquitiform (NU) approach was developed to characterize the mesostructural features of polymer-bonded explosives (PBXs), and then used to predicate some equivalent physical properties of PBXs, which can also be expected to be extended to o...

The drop tests of the experimental structure with explosive substitute material were carried out to study the dynamic deformation and failure of the explosive substitute. The PBX simulation material was designed as a cylindrical flat head structure,...

Acute lymphoblastic leukemia (ALL) represents the most common type of cancer in the pediatric population. The (1;19)(q23;p13) translocation is a primary chromosomal abnormality present in 3–12% of ALL cases. The current study aims to develop a...

Polysiloxanes are reviewed for their properties depending on the functionalization of a silicon–oxygen backbone chain. Next, the properties were referred to the requirements that polymers used in plastic/polymer-bonded explosive (PBX)-type explosives...

During early development, the heart tube grows by progressive addition of progenitor cells to the arterial and venous poles. These cardiac progenitor cells, originally identified in 2001, are located in the splanchnic mesoderm in a region termed the...

Knowledge of the diverse DNA binding specificities of transcription factors is important for understanding their specific regulatory functions in animal development and evolution. We have examined the genome-wide binding properties of the mouse HOXB1...

In order to better understand the role of binder content, molecular dynamics (MD) simulations were performed to study the interfacial interactions, sensitivity and mechanical properties of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane/2,...

This work studies the hypothesis of whether the UDP DoS attack affects voice and video flows in a VoIP network. It is a continuation of a previous work that studied the same hypothesis, but the VoIP server was under different types of TCP DoS attacks...

In today’s digital world, no one and nothing is safe from potential cyberattacks. There is also no 100% protection from such attacks. Therefore, it is advisable to carry out various studies related to the effects of the different cyberattacks o...

In order to investigate and compare the effects of RDX crystal quality on the safety and mechanical properties of pressed PBX, different RDX-based PBXs were prepared by a water suspension granulation method. The surface morphology, thermal decomposit...

The research problem described in this article is related to the security of an IP network that is set up between two cities using hosting. The network is used for transmitting telephone traffic between servers located in Germany and the Netherlands....

Acute lymphoblastic leukemia (ALL) is the most common type of malignant neoplasms in the pediatric population. B-cell precursor ALLs (BCP-ALLs) are derived from the progenitors of B lymphocytes. Traditionally, risk factors stratifying therapy in ALL...

Immunophenotypic characterization of leukemic cells with the use of flow cytometry (FC) is a fundamental tool in acute lymphoblastic leukemia (ALL) diagnostics. A variety of genetic aberrations underlie specific B-cell precursor ALL (BCP-ALL) subtype...

Ternary alloy Pb_xCd_1−xS quantum dots (QDs) were explored as photosensitizers for quantum-dot-sensitized solar cells (QDSCs). Alloy Pb_xCd_1−xS QDs (Pb_0.54Cd_0.46S, Pb_0.31Cd_0.69S, and Pb_0.24Cd_0.76S) were found to substantially improve the photocurrent of...

We have investigated the Pb-substitution effect upon the superconductivity of NaCl-type In_1−xPb_xTe. Polycrystalline samples with x = 0–0.8 were synthesized using high-pressure synthesis. The lattice parameter was systematically increased...

Fabry disease is an X-linked multisystemic disorder caused by the impairment of lysosomal α-Galactosidase A, which leads to the progressive accumulation of glycosphingolipids and to defective lysosomal metabolism. Currently, Fabry disease is tr...

The accidental initiation of explosives under mechanical loads has caused numerous catastrophic events. Therefore, the dynamic damage behavior of confined polymer-bonded explosives (PBXs) must be assessed to improve their practical applicability. In...

We present a Raman study on the phase transitions of organic/inorganic hybrid perovskite materials, CH₃NH₃PbX₃ (X = I, Br), which are used as solar cells with high power conversion efficiency. The temperature dependence of the Raman bands of CH₃NH₃Pb...

This paper explores the feasibility of producing manganese- and lead-doped luminescent materials from phosphogypsum. For the first time, orange- and red-emitting ultraviolet pigments were obtained using a sulfide matrix reduced from phosphogypsum. Th...

In order to study the fracture behavior and structure evolution of 1,3,5-Triamino-2,4,6-Trinitrobenzene (TATB)-based polymer bonded explosive in thermal-mechanical loading, in-situ studies were performed on X-ray computed tomography system using quas...

To study the design method and pressure relief effect of the mitigation structure of a shell under the action of thermal stimulation, a systematic research method of theoretical calculation-simulation-experimental verification of the mitigation struc...

The mechanical properties of composites are highly dependent on the interfacial interaction. In the present work, inspired by marine mussel, the adhesion between energetic crystals of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and polymer binders wa...

Ammonium dinitramide (ADN), a new-generation green high-energy oxidizer, faces application challenges due to its strong hygroscopicity and poor compatibility with polymer binders. This study proposes a double-shell structure with ADN as the core, gra...

Nowadays, Mn-doping is considered as a promising dissolution for the heavy usage of toxic lead in CsPbX₃ perovskite material. Interestingly, Mn-doping also introduces an additional photoluminescence band, which is favorable to enrich the emission gam...

The flotation and adsorption of a new polysaccharide konjac gum (KG) on pyrite and talc in the presence of pre-adsorbed potassium butyl xanthate (PBX) is investigated. The micro-flotation results show that KG is a quality depressant for talc and that...

Complexities of heating mechanisms make it difficult to investigate the safety of a polymer bonded explosive (PBX) charge of earth-penetrating-weapons (EPWs) during penetration. In this paper, the dynamic damage and non-shock initiation of PBX1314 (6...

(1) Background: To identify a particular setting of biopsy-naïve patients in which it would be reasonable to offer only cognitive targeted prostate biopsy (PBx) with a transrectal approach. (2) Methods: We designed an observational retrospective...