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8,330 Results Found

  • Article
  • Open Access
2 Citations
2,196 Views
11 Pages

Ultrafast Hydrogen Production via Hydrolysis of MgH2-NaH Composite

  • Zhao Zhang,
  • Zhenji Li,
  • Wei Zhao,
  • Yushan Zhang,
  • Chong Peng,
  • Changcheng Liu and
  • Li Guo

12 September 2024

Magnesium hydride (MgH2) has attracted considerable interest due to a number of favourable characteristics for hydrogen production via hydrolysis. In this study, MgH2-NaH composites with varying composition ratios were prepared by ball milling for di...

  • Article
  • Open Access
10 Citations
2,582 Views
14 Pages

5 November 2019

In this study, we investigated a mechanistic link between Na–H exchanger-1 (NHE-1) and carbonic anhydrase (CA) in experimental colitis induced in the rats by intrarectal administration of trinitrobenzenesulphonic acid (TNBS). Western blot analy...

  • Article
  • Open Access
519 Views
13 Pages

Na+/H+ Exchanger 1 Inhibition Overcomes Venetoclax Resistance in Acute Myeloid Leukemia

  • Shin Young Hyun,
  • Eun Jung Na,
  • Yu Ri Kim,
  • Yoo Hong Min and
  • June-Won Cheong

10 November 2025

Despite advances with novel targeted agents (e.g., BCL-2 or IDH inhibitors) combined with chemotherapy for acute myeloid leukemia (AML), drug resistance persists. We investigated whether blocking Na+/H+ exchanger 1 (NHE1) could enhance AML cell sensi...

  • Review
  • Open Access
18 Citations
5,289 Views
23 Pages

Prokaryotic Na+/H+ Exchangers—Transport Mechanism and Essential Residues

  • Miyer Patiño-Ruiz,
  • Constanța Ganea and
  • Octavian Călinescu

15 August 2022

Na+/H+ exchangers are essential for Na+ and pH homeostasis in all organisms. Human Na+/H+ exchangers are of high medical interest, and insights into their structure and function are aided by the investigation of prokaryotic homologues. Most prokaryot...

  • Article
  • Open Access
38 Citations
5,101 Views
23 Pages

Exogenous Potassium (K+) Positively Regulates Na+/H+ Antiport System, Carbohydrate Metabolism, and Ascorbate–Glutathione Cycle in H2S-Dependent Manner in NaCl-Stressed Tomato Seedling Roots

  • M. Nasir Khan,
  • Soumya Mukherjee,
  • Asma A. Al-Huqail,
  • Riyadh A. Basahi,
  • Hayssam M. Ali,
  • Bander M. A. Al-Munqedhi,
  • Manzer H. Siddiqui and
  • Hazem M. Kalaji

10 May 2021

Potassium (K+) is one of the vital macronutrients required by plants for proper growth and blossoming harvest. In addition, K+ also plays a decisive role in promoting tolerance to various stresses. Under stressful conditions, plants deploy their defe...

  • Article
  • Open Access
1,684 Views
17 Pages

14 October 2024

The collisions between Na atoms and H2 molecules are of great significance in the field of chemical reaction dynamics, but the corresponding dynamics results of ground-state reactions have not been reported experimentally or theoretically. Herein, a...

  • Article
  • Open Access
1 Citations
2,654 Views
14 Pages

Amino Acids 785, 787 of the Na+/H+ Exchanger Cytoplasmic Tail Modulate Protein Activity and Tail Conformation

  • Xiuju Li,
  • Tommy Tu,
  • Sicheng Quan,
  • Francisco J. Quintero,
  • Richard Fahlman and
  • Larry Fliegel

21 October 2021

The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a plasma membrane protein ubiquitously present in humans. It regulates intracellular pH by removing an intracellular proton in exchange for an extracellular sodium. It consists of a 500 amino acid me...

  • Article
  • Open Access
3 Citations
2,505 Views
10 Pages

Pseudo-Binary Phase Diagram of LiNH2-MH (M = Na, K) Eutectic Mixture

  • Pranjal Pathak,
  • Kriti Shrivastava,
  • Takayuki Ichikawa,
  • Ankur Jain and
  • Rini Singh

25 June 2022

The hunt for a cleaner energy carrier leads us to consider a source that produces no toxic byproducts. One of the targeted alternatives in this approach is hydrogen energy, which, unfortunately, suffers from a lack of efficient storage media. Solid-s...

  • Article
  • Open Access
13 Citations
3,087 Views
22 Pages

Targeting Hydrogen Sulfide Modulates Dexamethasone-Induced Muscle Atrophy and Microvascular Rarefaction, through Inhibition of NOX4 and Induction of MGF, M2 Macrophages and Endothelial Progenitors

  • Mohamed Adel,
  • Hassan Reda Hassan Elsayed,
  • Mohammad El-Nablaway,
  • Shereen Hamed,
  • Amira Eladl,
  • Samah Fouad,
  • Eman Mohamad El Nashar,
  • Mohammed Lafi Al-Otaibi and
  • Mohammed R. Rabei

11 August 2022

Long-term use of Glucocorticoids produces skeletal muscle atrophy and microvascular rarefaction. Hydrogen sulfide (H2S) has a potential role in skeletal muscle regeneration. However, the mechanisms still need to be elucidated. This is the first study...

  • Review
  • Open Access
8 Citations
2,889 Views
32 Pages

7 October 2023

Na+/H+ exchangers (NHEs) are known to be important regulators of pH in multiple intracellular compartments of eukaryotic cells. Sperm function is especially dependent on changes in pH and thus it has been postulated that NHEs play important roles in...

  • Article
  • Open Access
1,071 Views
24 Pages

SOS1 is a Na+/H+ antiporter found in the plant membrane of Arabidopsis thaliana and serves as a major transporter that extrudes Na+ across the plasma membrane of cells in exchange for intracellular H+. The first 450 amino acids comprise the membrane...

  • Review
  • Open Access
21 Citations
4,586 Views
16 Pages

Na+/H+ Exchanger 1, a Potential Therapeutic Drug Target for Cardiac Hypertrophy and Heart Failure

  • Huiting Xia,
  • Aqeela Zahra,
  • Meng Jia,
  • Qun Wang,
  • Yunfu Wang,
  • Susan L. Campbell and
  • Jianping Wu

Cardiac hypertrophy is defined as increased heart mass in response to increased hemodynamic requirements. Long-term cardiac hypertrophy, if not counteracted, will ultimately lead to heart failure. The incidence of heart failure is related to myocardi...

  • Article
  • Open Access
6 Citations
3,514 Views
18 Pages

Isoform one of the mammalian Na+/H+ exchanger is a plasma membrane protein that is ubiquitously present in humans. It regulates intracellular pH through the removal of one intracellular proton in exchange for a single extracellular sodium. It consist...

  • Review
  • Open Access
16 Citations
4,733 Views
14 Pages

High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

  • Ghassan Bkaily,
  • Yanick Simon,
  • Ashley Jazzar,
  • Houssein Najibeddine,
  • Alexandre Normand and
  • Danielle Jacques

Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as...

  • Article
  • Open Access
6 Citations
2,039 Views
16 Pages

The Na+/H+ antiporter NhaC family protein is a kind of Na+/H+ exchanger from the ion transporter (IT) superfamily, which has mainly been identified in the halophilic bacteria of Bacillus. However, little is known about the Na+/H+ antiporter NhaC fami...

  • Review
  • Open Access
37 Citations
8,947 Views
19 Pages

The human Na+/H+ exchanger isoform 1 (NHE1) is a plasma membrane transport protein that plays an important role in pH regulation in mammalian cells. Because of the generation of protons by intermediary metabolism as well as the negative membrane pote...

  • Article
  • Open Access
17 Citations
2,716 Views
12 Pages

Na+/H+ Exchangers Involve in Regulating the pH-Sensitive Ion Channels in Mouse Sperm

  • Hang Kang,
  • Min Liu,
  • Wei Zhang,
  • Rong-Zu Huang,
  • Na Zhao,
  • Chen Chen and
  • Xu-Hui Zeng

5 February 2021

Sperm-specific K+ ion channel (KSper) and Ca2+ ion channel (CatSper), whose elimination causes male infertility in mice, determine the membrane potential and Ca2+ influx, respectively. KSper and CatSper can be activated by cytosolic alkalization, whi...

  • Article
  • Open Access
16 Citations
2,963 Views
14 Pages

GhNHX3D, a Vacuolar-Localized Na+/H+ Antiporter, Positively Regulates Salt Response in Upland Cotton

  • Junping Feng,
  • Wenyu Ma,
  • Zongbin Ma,
  • Zhongying Ren,
  • Yang Zhou,
  • Junjie Zhao,
  • Wei Li and
  • Wei Liu

Vacuolar sodium/proton (Na+/H+) antiporters (NHXs) can stabilize ion contents to improve the salt tolerance of plants. Here, GhNHX3D was cloned and characterized from upland cotton (Gossypium hirsutum). Phylogenetic and sequence analyses showed that...

  • Article
  • Open Access
38 Citations
7,554 Views
27 Pages

Soil salinity is a main abiotic stress in agriculture worldwide. The Na+/H+ antiporters (NHXs) play pivotal roles in intracellular Na+ excretion and vacuolar Na+ compartmentalization, which are important for plant salt stress resistance (SSR). Howeve...

  • Article
  • Open Access
10 Citations
3,501 Views
17 Pages

Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion

  • Xiuju Li,
  • Benjamin Buckley,
  • Konstantin Stoletov,
  • Yang Jing,
  • Marie Ranson,
  • John D. Lewis,
  • Mike Kelso and
  • Larry Fliegel

9 December 2021

Prostate cancer is a leading cause of cancer-associated deaths in men over 60 years of age. Most patients are killed by tumor metastasis. Recent evidence has implicated a role of the tumor microenvironment and urokinase plasminogen activator (uPA) in...

  • Article
  • Open Access
2,070 Views
13 Pages

Depletion of Na+/H+ Exchanger Isoform 1 Increases the Host Cell Resistance to Trypanosoma cruzi Invasion

  • João Paulo Ferreira Rodrigues,
  • Leonardo Loch,
  • Thiago Souza Onofre and
  • Nobuko Yoshida

4 November 2022

Na+/H+ exchanger isoform 1 (NHE1), a member of a large family of integral membrane proteins, plays a role in regulating the cortical actin cytoskeleton. Trypanosoma cruzi, the agent of Chagas disease, depends on F-actin rearrangement and lysosome mob...

  • Article
  • Open Access
80 Citations
6,615 Views
19 Pages

27 May 2019

Salinity is one of the major environment factors that limits the growth of plants and the productivity of crops worldwide. It has been shown that Na+ transporters play a central role in salt tolerance and development of plants. The objective of this...

  • Article
  • Open Access
15 Citations
2,900 Views
17 Pages

Na+/H+ exchangers (NHEs) are a family of ion transporters that regulate the pH of various cell compartments across an array of cell types. In eukaryotes, NHEs are encoded by the SLC9 gene family comprising 13 genes. SLC9C2, which encodes the NHE11 pr...

  • Review
  • Open Access
9 Citations
3,597 Views
14 Pages

17 September 2022

The Na+/H+ exchanger transporters (NHE) play an important role in various biologic processes including Na+ absorption, intracellular pH homeostasis, cell volume regulation, proliferation, and apoptosis. The wide expression pattern and cellular locali...

  • Article
  • Open Access
1 Citations
2,401 Views
10 Pages

20 February 2023

Hydrangea macrophylla is popular for its unique physiological characteristics and changeable colors. Previous studies have shown that the pH of the vacuoles of the sepal cells of hydrangea affects the color of the sepals. Located on the vacuolar memb...

  • Article
  • Open Access
2 Citations
2,977 Views
19 Pages

26 February 2023

Ceramic materials in Na2O-CaO-P2O5 system were obtained by firing cement-salt stone made from pastes based on powder mixtures including calcium citrate tetrahydrate Ca3(C6H5O7)2∙4H2O, monocalcium phosphate monohydrate (MCPM) Ca(H2PO4)2∙H2...

  • Article
  • Open Access
11 Citations
2,869 Views
16 Pages

Human Colonoid–Myofibroblast Coculture for Study of Apical Na+/H+ Exchangers of the Lower Cryptal Neck Region

  • Azam Salari,
  • Kunyan Zhou,
  • Katerina Nikolovska,
  • Ursula Seidler and
  • Mahdi Amiri

21 February 2023

Cation and anion transport in the colonocyte apical membrane is highly spatially organized along the cryptal axis. Because of lack of experimental accessibility, information about the functionality of ion transporters in the colonocyte apical membran...

  • Article
  • Open Access
44 Citations
9,216 Views
16 Pages

25 June 2013

The aim of the study was to investigate the protective effects of sodium hydrosulfide (NaHS), a H2S donor, against hypoxia-induced injury in human umbilical vein endothelial cells (HUVECs) and also to look into the possible mechanisms by which H2S exe...

  • Article
  • Open Access
1 Citations
1,989 Views
12 Pages

28 December 2023

Renewable electricity products, for example, from wind and photovoltaic energy, need large-scale and economic energy storage systems to guarantee the requirements of our daily lives. Sodium-ion batteries are considered more economical than lithium-io...

  • Article
  • Open Access
6 Citations
2,554 Views
15 Pages

13 February 2024

Milled MgH2, MgH2-10NaAlH4, MgH2-30NaAlH4, MgH2-50NaAlH4, and MgH2-2Ni-10NaAlH4 samples were prepared by milling in a planetary ball mill in hydrogen atmosphere (reactive mechanical milling, RMM). Decomposition temperatures of milled MgH2, NaAlH4, Mg...

  • Article
  • Open Access
2,363 Views
8 Pages

2 September 2020

This study aimed to determine the bactericidal efficacy of sequential use of NaOCl pH 12 followed by acidified NaOCl pH 6.5, and compare it to that of either of these NaOCl solutions alone. E. faecalis biofilm was grown on standardized dentine specim...

  • Article
  • Open Access
30 Citations
7,546 Views
11 Pages

Effect of Sodium Sulfite on Floatability of Chalcopyrite and Molybdenite

  • Hajime Miki,
  • Tsuyoshi Hirajima,
  • Yukihiro Muta,
  • Gde Pandhe Wisnu Suyantara and
  • Keiko Sasaki

22 April 2018

Sodium hydrogen sulfide (NaHS) is commonly used as a copper depressant in the selective flotation of copper and molybdenum ores. However, the process is facing health and safety issues because NaHS readily yields toxic hydrogen sulfide gas (H2S) unde...

  • Article
  • Open Access
3 Citations
2,553 Views
11 Pages

Simultaneous Differential Detection of H5, H7, H9 and Nine NA Subtypes of Avian Influenza Viruses via a GeXP Assay

  • Sisi Luo,
  • Zhixun Xie,
  • Meng Li,
  • Dan Li,
  • Minxiu Zhang,
  • Zhihua Ruan,
  • Liji Xie,
  • Sheng Wang,
  • Qing Fan and
  • Yanfang Zhang
  • + 2 authors

H5, H7 and H9 are the most important subtypes of avian influenza viruses (AIVs), and nine neuraminidase (NA) subtypes (N1–N9) of AIVs have been identified in poultry. A method that can simultaneously detect H5, H7, H9 and the nine NA subtypes o...

  • Article
  • Open Access
5 Citations
1,892 Views
13 Pages

Natrium Diacid Phosphate-Manganese-Lead Vitroceramics Obtained from Spent Electrodes

  • Denisa Cuibus,
  • Simona Rada,
  • Sergiu Macavei and
  • Horatiu Vermesan

28 February 2023

NaH2PO4-MnO2-PbO2-Pb vitroceramics were studied usinginfrared (IR), ultraviolet-visible (UV-Vis) and electron paramagnetic resonance (EPR) spectroscopies to understand the structural modifications as potential candidates for electrode materials. The...

  • Article
  • Open Access
5 Citations
2,559 Views
7 Pages

22 September 2022

Alkali metal (M = Na, K) salts of the [CB11H12]− anion have attracted increasing attention in many fields such as catalysis and all-solid-state batteries. However, tedious and low-yielding synthetic methods have seriously limited their applicat...

  • Article
  • Open Access
2 Citations
4,883 Views
12 Pages

Calcium Signaling Involves Na+/H+ Exchanger and IP3 Receptor Activation in T. cruzi Epimastigotes

  • Melina Usorach,
  • Alba Marina Gimenez,
  • Micaela Peppino Margutti,
  • Graciela E. Racagni and
  • Estela E. Machado

8 November 2021

The calcium ion (Ca2+) plays a fundamental role in the metabolism and cell physiology of eukaryotic cells. In general, increases in cytosolic Ca2+ may come from both of the extracellular environment through specific channels and/or calcium release fr...

  • Article
  • Open Access
22 Citations
4,521 Views
11 Pages

27 September 2018

Using Non-invasive Micro-test Technology (NMT), the Na+, K+ and H+ flux profiles in the root meristem regions were investigated in Nitraria sibirica Pall. seedlings under different NaCl concentrations. NaCl stress increased the K+ and Na+ contents in...

  • Article
  • Open Access
1,662 Views
16 Pages

Electrochemical Machining of Micro-Pit Arrays on a GH4169 Alloy with a Roll-Print Mask Using a C6H5Na3O7-Containing NaNO3 Mixed Electrolyte

  • Ge Qin,
  • Shiwei Li,
  • Meng Li,
  • Haoyu Peng,
  • Shen Niu,
  • Xinchao Li,
  • Huan Liu,
  • Liang Yan and
  • Pingmei Ming

12 October 2024

GH4169 alloy, a nickel-based superalloy known for its excellent high temperature resistance, corrosion resistance, mechanical properties, and high-temperature tribological properties, is widely used in industrial applications, such as in gas turbines...

  • Article
  • Open Access
4 Citations
2,609 Views
22 Pages

Comprehensive In Silico Analysis of the NHX (Na+/H+ Antiporter) Gene in Rice (Oryza sativa L.)

  • Hoa Hai Thi Bui,
  • Duong Huy Nguyen,
  • Le Thu Thi Dinh,
  • Hang Thu Thi Trinh,
  • Thoa Kim Vu and
  • Van Ngoc Bui

The Na+/H+ antiporter (NHX) gene family plays a pivotal role in plant salt tolerance in regulating intracellular Na+ and H+ homeostasis. In this study, seven candidate OsNHX genes (OsNHX1 to OsNHX7) were identified in the rice genome and classified i...

  • Article
  • Open Access
7 Citations
12,228 Views
8 Pages

4 August 2017

Extracting AlCl3·6H2O from acid leaching solution through crystallization is one of the key processes to extracting aluminum from fly ash, coal gangue and other industrial solid wastes. However, the obtained products usually have low purity and a key...

  • Article
  • Open Access
35 Citations
11,363 Views
18 Pages

29 August 2014

Na+/H+ antiporters (NHXs) are integral membrane transporters that catalyze the electroneutral exchange of K+ or Na+ for H+ and are implicated in cell expansion, development, pH and ion homeostasis and salt tolerance. Arabidopsis contains four vacuola...

  • Article
  • Open Access
4 Citations
1,877 Views
13 Pages

Effect of H2O Molecule Adsorption on the Electronic Structure and Optical Properties of the CsI(Na) Crystal

  • Fang Liu,
  • Hao Zheng,
  • Tianze Jiang,
  • Bin Liu,
  • Jianming Zhang,
  • Hang Yuan,
  • Fengcheng Liu,
  • Xiaoxue Fan and
  • Xiaoping Ouyang

31 March 2021

We investigated H2O molecule adsorption that had an effect on the luminescence properties of the CsI(Na) crystal using experiments and first-principle calculations. We measured the emission spectra of the CsI(Na) crystal at different exposure times u...

  • Article
  • Open Access
5 Citations
2,901 Views
12 Pages

Effects of Hydrogen Sulfide Donor NaHS on Porcine Vascular Wall-Mesenchymal Stem Cells

  • Chiara Bernardini,
  • Debora La Mantia,
  • Salvatore Nesci,
  • Roberta Salaroli,
  • Cristina Algieri,
  • Alessandra Pagliarani,
  • Augusta Zannoni and
  • Monica Forni

Hydrogen sulfide (H2S) is now considered not only for its toxicity, but also as an endogenously produced gas transmitter with multiple physiological roles, also in maintaining and regulating stem cell physiology. In the present work, we evaluated the...

  • Article
  • Open Access
10 Citations
3,274 Views
15 Pages

28 May 2021

Nitraria tangutorum Bobrov is a halophyte that is resistant to salt and alkali and is widely distributed in northwestern China. However, its genome has not been sequenced, thereby limiting studies on this particular species. For species without a ref...

  • Article
  • Open Access
18 Citations
6,211 Views
10 Pages

The Improvement of Dehydriding the Kinetics of NaMgH3 Hydride via Doping with Carbon Nanomaterials

  • Zhong-Min Wang,
  • Song Tao,
  • Jia-Jun Li,
  • Jian-Qiu Deng,
  • Huaiying Zhou and
  • Qingrong Yao

30 December 2016

NaMgH3 perovskite hydride and NaMgH3–carbon nanomaterials (NH-CM) composites were prepared via the reactive ball-milling method. To investigate the catalytic effect of CM on the dehydriding kinetic properties of NaMgH3 hydride, multiwall carbon nanot...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,709 Views
15 Pages

6 November 2024

In this study, Raman spectroscopy is applied to determine the salinity of fluid inclusions in the H2O-NaCl-CO2 system. In the work, various systems are prepared, such as H2O-NaCl, H2O-CO2, and H2O-NaCl-CO2. For the H2O-NaCl system, the addition of Na...

  • Article
  • Open Access
699 Views
17 Pages

24 September 2025

Porous aluminum alloys are widely used for lightweight structural materials such as marine structures, energy absorbers, and buoyant components. However, the conventional foaming agent TiH2 presents limitations such as high cost and elevated decompos...

  • Article
  • Open Access
26 Citations
10,263 Views
13 Pages

Revisiting the Hydrogen Storage Behavior of the Na-O-H System

  • Jianfeng Mao,
  • Qinfen Gu and
  • Duncan H. Gregory

28 April 2015

Solid-state reactions between sodium hydride and sodium hydroxide are unusual among hydride-hydroxide systems since hydrogen can be stored reversibly. In order to understand the relationship between hydrogen uptake/release properties and phase/struct...

  • Article
  • Open Access
5 Citations
2,228 Views
15 Pages

On the Importance of H-Bonding Interactions in the Enclathration of Boric Acids in Na(I) Polymers: Experimental and Theoretical Studies

  • Trishnajyoti Baishya,
  • Kamal K. Dutta,
  • Antonio Frontera,
  • Rosa M. Gomila,
  • Miquel Barceló-Oliver and
  • Manjit K. Bhattacharyya

30 May 2023

Two Na(I) coordination polymers, namely, {Na(BA)2(μ-H2O)2}n{adp}n (1) and {[Na2(μ-BA)(μ-fum)(μ-H2O)4](BA)}n (2) (where, BA = boric acid, adp = adipic acid, fum = fumarate),were prepared and characterized using elemental analysis, TGA, FT-...

  • Article
  • Open Access
28 Citations
5,619 Views
16 Pages

9 November 2018

In this paper, a series of Na2SO4·10H2O–KCl eutectic mixtures were prepared by adding different mass fractions of KCl (1 wt.%, 3 wt.%, 5 wt.%, or 7 wt.%) to Na2SO4·10H2O. Polyacrylamide (PAM) was proposed as the thickener, sodium...

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