Myxoma virus (MYXV) is Leporipoxvirus that possesses a specific rabbit‐restricted host tropism but exhibits a much broader cellular host range in cultured cells. MYXV is able to efficiently block all aspects of the type I interferon (IFN)‐induced...
Myxoma virus (MYXV) is the prototypic member of the Leporipoxvirus genus of the Poxviridae family of viruses. In nature, MYXV is highly restricted to leporids and causes a lethal disease called myxomatosis only in European rabbits (Oryctologous cunic...
The generalization of binary operation in the classical algebra to fuzzy binary operation is an important development in the field of fuzzy algebra. The paper proposes a new generalization of vector spaces over field, which is called M-hazy vector sp...
In the new era of connectivity, marked by the explosive number of wireless electronic devices and the need for smart and pervasive applications, Machine-to-Machine (M2M) communications are an emerging technology that enables the seamless device inter...
N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic messenger RNAs (mRNAs). The m6A modification in RNA can be catalyzed by methyltransferases, or removed by demethylases, which are termed m6A writers and erasers, respe...
Chemical modifications of cellular RNAs play key roles in gene expression and host defense. The cap-adjacent N6,2′-O-dimethyladenosine (m6Am) is a prevalent modification of vertebrate and viral mRNAs and is catalyzed by the newly discovered N6...
Security is a challenging issue for M2M/IoT applications due to the deployment, decentralization and heterogeneity of M2M and IoT devices. Typical security solutions may not be suitable for M2M/IoT systems regarding the difficulties encountered for t...
N6-methyladenosine (m6A) modification, the most prevalent RNA modification, is involved in all aspects of RNA metabolism, including RNA processing, nuclear export, stability, translation and degradation. Therefore, m6A modification can participate in...
[M(bpy)3]q+ cations (bpy = 2,2′-bipyridine) are archetypical coordination entities containing chelating bidentate N,N′-donor ligands. Each propeller-shaped cation is chiral, existing as a Δ or Λ enantiomer. The supramolecular...
As the core of intelligent manufacturing, cyber-physical systems (CPS) have serious security issues, especially for the communication security of their terminal machine-to-machine (M2M) communications. In this paper, blockchain technology is introduc...
N6-methyladenosine (m6A) is the most abundant modification of mRNA and plays a crucial role in mediating cellular functions, and it is associated with cancer and neurodegenerative diseases. Studies have shown that m6A is predominantly deposited on it...
The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given the presence of retained introns and instability AU-rich sequences, this viral transc...
Acanthamoeba is free-living protist pathogen capable of causing a blinding keratitis and granulomatous encephalitis. However, the mechanisms of Acanthamoeba pathogenesis are still not clear. Here, our results show that cells co-cultured with pathogen...
The mammalian target of rapamycin complex 1 (mTORC1) is involved in the cellular transcription and translation processes. The undertaken study characterized the enhancer of mRNA decapping protein 4 (Edc4) as mTORC1 interacting protein. Human T lym...
Machine-to-machine (M2M) communication consists of the communication between intelligent devices without human intervention. Long term evolution (LTE) and Long-term evolution-advanced (LTE-A) cellular networks technologies are excellent candidates to...
With the increasing demand of Machine to Machine (M2M) communications and Internet of Things (IoT) services it is necessary to develop a new network architecture and protocols to support cost effective, distributed computing systems. Generally, M2M a...
The M-eigenvalue of elasticity M-tensors play important roles in nonlinear elastic material analysis. In this paper, we establish an upper bound and two sharp lower bounds for the minimum M-eigenvalue of elasticity M-tensors without irreducible condi...
mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These va...
Mathematical modelling is an important aspect in apprehending discrete and continuous physical systems. Multipolar uncertainty in data and information incorporates a significant role in various abstract and applied mathematical modelling and decision...
For in vivo application of mRNA therapeutics, the development of mRNA nanocarriers that protect mRNA from enzymatic degradation is needed. While current nanocarrier development focuses on fine-tuning the chemical structure of its components, includin...
Machine-to-machine (M2M) intelligent network devices are exposed to vulnerable networks and security threats always exist. The devices are composed of low-capacity hardware by their nature and are exposed to various security threats such as worms, vi...
Monomeric C-reactive protein (mCRP) has recently been implicated in the abnormal vascular activation associated with development of atherosclerosis, but it may act more specifically through mechanisms perpetuating damaged vessel inflammation and subs...
Our aim in this study is to consider a generalization of the concept of m-complex symmetric transformations to n-quasi-m-complex symmetric transformations. A map S∈B(Y) is said to be an n-quasi-m-complex symmetric transformation if there exists...
Background: Microglia are key cells of the immune system in the central nervous system and are suggested to be deeply involved in the development of neurodegenerative diseases. It is well known that microglia have functional plasticity, with an infla...
Over recent years, epitranscriptomic research has provided a new layer of gene regulation during hematopoietic development and aberrant hematopoiesis. Among the 170 identified RNA chemical marks, N6-methyladenosine (m6A) is the most abundant in eukar...
The mammalian target of rapamycin (mTOR) kinase is a well-known master regulator of growth-dependent gene expression in higher eukaryotes. Translation regulation is an important function of the mTORC1 pathway that controls the synthesis of many ribos...
In machine-to-machine (M2M) networks, a key challenge is to overcome the overload problem caused by random access requests from massive machine-type communication (MTC) devices. When differentiated services coexist, such as delay-sensitive and delay-...
Psychiatric disorders such as schizophrenia and major depressive disorder were thought to be caused by neurotransmitter abnormalities. Patients with these disorders often experience relapse and remission; however the underlying molecular mechanisms o...
Macrophages play an important role in the early development of type 1 diabetes (T1D). Based on the phenotype, macrophages can be classified into pro-inflammatory (M1) and anti-inflammatory (M2) macrophages. Despite intensive research in the field of...
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is we...
True genetically encoded monomeric fluorescent timers (tFTs) change their fluorescent color as a result of the complete transition of the blue form into the red form over time. Tandem FTs (tdFTs) change their color as a consequence of the fast and sl...
The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation have been uncovered leading to the emerging field of epitrans...
mTOR plays a crucial role in cell growth by controlling ribosome biogenesis, metabolism, autophagy, mRNA translation, and cytoskeleton organization. It is a serine/threonine kinase that is part of two distinct extensively described protein complexes,...
Thispaper compares the usability of various Apple MacBook Pro laptops were tested for basic machine learning research applications, including text-based, vision-based, and tabular data. Four tests/benchmarks were conducted using four different MacBoo...
Motivated by Botelho and Jamison’s seminal 2010 study on elementary operators that are m-isometries, in this paper, we introduce the concept of m-null pairs of operators and establish some structural properties and characterizations of the clas...
Cellular-based machine-to-machine (M2M) communication is expected to facilitate services for the Internet of Things (IoT). However, because cellular networks are designed for human users, they have some limitations. Random access channel (RACH) conge...
Renal fibrosis is regarded as the common final pathway leading to chronic kidney diseases; macrophages and myofibroblasts play important roles in the development of fibrosis. F344 rats were injected once with cisplatin (CDDP; 6 mg/kg BW) for renal le...
Both DNA 5-methylcytosine (5mC) and RNA N6-methyladenosine (m6A) modifications are reported to participate in cellular stress responses including inflammation. Phosphoenolpyruvate carboxykinase 2 (PCK2) is upregulated in Kupffer cells (KCs) to facili...
Cancer cells support their growth and proliferation by reprogramming their metabolism in order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to tumorigenesis, a common alteration in tumors occurs in pathways th...
In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in u...
In this paper, we present an implementation work of sensing and actuation capabilities for IoT devices using the oneM2M standard-based platforms. We mainly focus on the heterogeneity of the hardware interfaces employed in IoT devices. For IoT devices...
On a particular class of m-idempotent hyperrings, the relation ξ m * is the smallest strongly regular equivalence such that the related quotient ring is commutative. Thus, on such hyperrings, ξ m * is a new representation for th...
The recent increase in the number of connected IoT devices, as well as the heterogeneity of the environments where they are deployed, has derived into the growth of the complexity of Machine-to-Machine (M2M) communication protocols and technologies....
Machine-to-machine (M2M) communication is a key enabling technology for industrial internet of things (IIoT)-empowered industrial networks, where machines communicate with one another for collaborative automation and intelligent optimisation. This ne...
The structural, electronic and magnetic properties of Cu4M (M = Sc-Ni) clusters have been studied by using density functional theory, together with an unbiased CALYPSO structure searching method. Geometry optimizations indicate that M atoms in the gr...
Macrophage colony-stimulating factor (M-CSF or CSF-1) is known to have a broad range of actions on myeloid cells maturation, including the regulation of macrophage differentiation, proliferation and survival. Macrophages generated by M-CSF stimulus h...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1...
In this review, we provide recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, with a particular focus on cerebral ischemia. We cover the upstream and downstream pathways that regulate the activation s...
Gene expression in eukaryotes begins with transcription in the nucleus, followed by the synthesis of messenger RNA (mRNA), which is then exported to the cytoplasm for its translation into proteins. Along with transcription and translation, mRNA expor...
The central objective of the proposed work in this research is to introduce the innovative concept of an m-polar fuzzy set (m-PFS) in semigroups, that is, the expansion of bipolar fuzzy set (BFS). Our main focus in this study is the generalization of...
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