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Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries

Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad of Chile, Independencia 834100, Santiago, Chile
Authors to whom correspondence should be addressed.
Academic Editors: J. Robert Hogg and Karen L. Beemon
Viruses 2016, 8(11), 320;
Received: 1 October 2016 / Revised: 12 November 2016 / Accepted: 14 November 2016 / Published: 23 November 2016
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given the presence of retained introns and instability AU-rich sequences, this viral transcript is normally retained and degraded in the nucleus of host cells unless the viral protein REV is present. As such, the stability of the HIV-1 unspliced mRNA must be particularly controlled in the nucleus and the cytoplasm in order to ensure proper levels of this viral mRNA for translation and viral particle formation. During its journey, the HIV-1 unspliced mRNA assembles into highly specific messenger ribonucleoproteins (mRNPs) containing many different host proteins, amongst which are well-known regulators of cytoplasmic mRNA decay pathways such as up-frameshift suppressor 1 homolog (UPF1), Staufen double-stranded RNA binding protein 1/2 (STAU1/2), or components of miRNA-induced silencing complex (miRISC) and processing bodies (PBs). More recently, the HIV-1 unspliced mRNA was shown to contain N6-methyladenosine (m6A), allowing the recruitment of YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), an m6A reader host protein involved in mRNA decay. Interestingly, these host proteins involved in mRNA decay were shown to play positive roles in viral gene expression and viral particle assembly, suggesting that HIV-1 interacts with mRNA decay components to successfully accomplish viral replication. This review summarizes the state of the art in terms of the interactions between HIV-1 unspliced mRNA and components of different host mRNA decay machineries. View Full-Text
Keywords: HIV-1 unspliced mRNA; mRNA decay; REV; UPF1; Staufen; m6A; YTHDF2 HIV-1 unspliced mRNA; mRNA decay; REV; UPF1; Staufen; m6A; YTHDF2
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Toro-Ascuy, D.; Rojas-Araya, B.; Valiente-Echeverría, F.; Soto-Rifo, R. Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries. Viruses 2016, 8, 320.

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