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The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Regulation of mTORC2 Signaling

by 1,2,* and 2
Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
Biozentrum, University of Basel, CH4056 Basel, Switzerland
Author to whom correspondence should be addressed.
Genes 2020, 11(9), 1045;
Received: 22 August 2020 / Revised: 31 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Cellular Growth Control by TOR Signaling)
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity. View Full-Text
Keywords: mTOR; mTORC2 signaling; Akt; signaling crosstalk mTOR; mTORC2 signaling; Akt; signaling crosstalk
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MDPI and ACS Style

Fu, W.; Hall, M.N. Regulation of mTORC2 Signaling. Genes 2020, 11, 1045.

AMA Style

Fu W, Hall MN. Regulation of mTORC2 Signaling. Genes. 2020; 11(9):1045.

Chicago/Turabian Style

Fu, Wenxiang, and Michael N. Hall 2020. "Regulation of mTORC2 Signaling" Genes 11, no. 9: 1045.

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