Next Article in Journal
An Overview of Duplicated Gene Detection Methods: Why the Duplication Mechanism Has to Be Accounted for in Their Choice
Next Article in Special Issue
The Plant Target of Rapamycin: A Conduc TOR of Nutrition and Metabolism in Photosynthetic Organisms
Previous Article in Journal
Genetic Hypothesis and Pharmacogenetics Side of Renin-Angiotensin-System in COVID-19
Previous Article in Special Issue
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Review

Regulation of mTORC2 Signaling

by 1,2,* and 2
1
Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
2
Biozentrum, University of Basel, CH4056 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Genes 2020, 11(9), 1045; https://doi.org/10.3390/genes11091045
Received: 22 August 2020 / Revised: 31 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Cellular Growth Control by TOR Signaling)
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity. View Full-Text
Keywords: mTOR; mTORC2 signaling; Akt; signaling crosstalk mTOR; mTORC2 signaling; Akt; signaling crosstalk
Show Figures

Graphical abstract

MDPI and ACS Style

Fu, W.; Hall, M.N. Regulation of mTORC2 Signaling. Genes 2020, 11, 1045. https://doi.org/10.3390/genes11091045

AMA Style

Fu W, Hall MN. Regulation of mTORC2 Signaling. Genes. 2020; 11(9):1045. https://doi.org/10.3390/genes11091045

Chicago/Turabian Style

Fu, Wenxiang, and Michael N. Hall 2020. "Regulation of mTORC2 Signaling" Genes 11, no. 9: 1045. https://doi.org/10.3390/genes11091045

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop