Intracellular chloride levels in the brain are regulated primarily through the opposing effects of two cation-chloride co-transporters (CCCs), namely K+-Cl− co-transporter-2 (KCC2) and Na+-K+-Cl− co-transporter-1 (NKCC1). These CCCs are d...
Approximately one-third of epileptic patients do not respond adequately to drug therapy, leading to the development of drug-resistant epilepsy. Given the established role of dysregulated expression of two cation–chloride cotransporter proteins,...
Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies...
RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small...
The strength of inhibitory neurotransmission depends on intracellular neuronal chloride concentration, primarily regulated by the activity of cation–chloride cotransporters NKCC1 (Sodium–Potassium–Chloride Cotransporter 1) and KCC2...
Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium–chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, a...
The behavior of the simplest realistic Oregonator model of the BZ-reaction from the perspective of KCC theory has been investigated. In order to reduce the complexity of the model, we initially transformed the first-order differential equation of the...
The potassium–chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role in the activity of the inhibitory neurotransmitters (GABA and glycine) since low levels of KCC2 promote intracellular Cl- accumulation...
Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exoge...
In this paper, we consider an autonomous two-dimensional ODE Kolmogorov-type system with three parameters, which is a particular system of the general predator–prey systems with a Holling type II. By reformulating this system as a set of two se...
KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated. We investigated the impa...
A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions...
Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the currently available pharmacological strategies to combat this global disease are scanty. Cation-chloride cotransporters (CCCs) are expressed in several tis...
Neuronal chloride (Cl−) homeostasis is fundamental for brain function, with disruptions increasingly recognized as pathogenic across neurological disorders. This review synthesizes evidence from preclinical models and clinical studies, integrat...
Plant cation–chloride cotransporters (CCCs) are proposed to be Na+-K+-2Cl− transporting membrane proteins, although evolutionarily, they associate more closely with K+-Cl− cotransporters (KCCs). Here, we investigated grapevine (Viti...
Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief. Recent evidence suggests the γ-aminobutyric acid (...
Previous studies reported that repetitive hypoxia in rat pups reduces insulin secretion and elevates fasting blood glucose levels; these sequelae persisted for several months. This report describes how episodic hypoxic events elevate a chloride ion e...
In this work, we will consider an autonomous three-dimensional quadratic system of first-order ordinary differential equations, with five parameters and with symmetry relative to the z-axis, which generalize the Hopf–Langford system. By reformu...
Neuronal ischemia results in chloride gradient alterations which impact the excitatory–inhibitory balance, volume regulation, and neuronal survival. Thus, the Na+/K+/Cl− co-transporter (NKCC1), the K+/ Cl− co-transporter (KCC2), and...
In this paper will be considered a three-dimensional autonomous quadratic polynomial system of first-order differential equations with three real parameters, the so-called T-system. This system is symmetric relative to the
The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading. The CCCs pl...
The neurotransmitter GABA is normally characterized as having an inhibitory effect on neural activity in the adult central nervous system (CNS), which quells over-excitation and limits neural plasticity. Spinal cord injury (SCI) can bring about a mod...
In the present work, two SIR patterns with demography will be considered: the classical pattern and a modified pattern with a linear coefficient of the infection transmission. By reformulating of each first-order differential systems as a system with...
GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl−]i due to the delayed expression of the chloride exporter KCC2 at birth. D...
It is necessary to elucidate the individual effects of temozolomide (TMZ) on carcinogenesis and tumor resistance to chemotherapy mechanisms. The study aimed to investigate the TMZ 50 and 100 μM dose effect difference between PBT24 and SF8628 cell...
Copper catalysts have been extensively studied for CO oxidation at low temperatures. Previous findings on the stability of such catalysts, on the other hand, revealed that they deactivated badly under extreme circumstances. Therefore, in this work, a...
Bipolar disorder (BP) is a recurring psychiatric condition characterized by alternating episodes of low energy (depressions) followed by manias (high energy). Cortical network activity produced by GABAergic interneurons may be critical in maintaining...
The elimination of ground reaction force (support withdrawal) vastly affects slow postural muscles in terms of their regulation and structure. One of the effects of support withdrawal in this study was an immediate postural muscle inactivation, follo...
By reformulating the circuit system of Lü as a set of two second order differential equations, we investigate the nonlinear dynamics of Lü’s circuit system from the Jacobi stability point of view, using Kosambi–Cartan–Cher...
Rett syndrome, a serious neurodevelopmental disorder, has been associated with an altered expression of different synaptic-related proteins and aberrant glutamatergic and γ-aminobutyric acid (GABA)ergic neurotransmission. Despite its severity,...
In the present work, 1.92 wt% Pd/9.68 wt% CeO2/spherical mesoporous silica (denoted as 1.92Pd/9.68CeO2/KCC-1) and 1.96 wt% Pd/KCC-1 (denoted as 1.96Pd/KCC-1) catalysts were prepared. It was found that the 1.92Pd/9.68CeO2/KCC-1 sample exhibited an exc...
In this work, the microwave-assisted reaction of 5-hydroxymethylfurfural (5-HMF) into valuable ether and acylated production formation was investigated with the help of molybdophosphoric acid encapsulated dendritic fibrous silica (KCC-1) as a catalys...
By utilizing the Kosambi–Cartan–Chern (KCC) geometric theory, this paper is dedicated to providing novel insights into the Liu dynamical system, which stands out as one of the most distinctive and noteworthy nonlinear dynamical systems. F...
Migraine is frequently comorbid with depression and anxiety disorders. In the case of depression and panic disorder, the associations seem to be bidirectional. Stress (activation of the hypothalamic-pituitary-adrenal axis) is thought to be involved i...
Although some recent developments in nanotechnology made the prospects of a direct mechanical manipulation of micro- or nano-objects quite realistic, there are still several concerns and difficulties that affect such an endeavor. This is probably due...
Spasticity impacts the quality of life of patients suffering spinal cord injury and impedes the recovery of locomotion. At the cellular level, spasticity is considered to be primarily caused by the hyperexcitability of spinal α-motoneurons (MNs...
Valproic acid (VPA) is a histone deacetylase inhibitor with sex-specific immunomodulatory and anticancer effects. This study aimed to investigate the effect of 0.5 and 0.75 mM VPA on NKCC1 (SLC12A2), KCC2 (SLC12A5) and SLC5A8 (SLC5A8) co-transporter...
Impaired rate-dependent depression (RDD) of the spinal H-reflex occurs in diabetic rodents and a sub-set of patients with painful diabetic neuropathy. RDD is unaffected in animal models of painful neuropathy associated with peripheral pain mechanisms...
In neuronal precursors and immature neurons, the depolarizing (excitatory) effect of γ-Aminobutyric acid (GABA) signaling is associated with elevated [Cl−]i; as brain cells mature, a developmental switch occurs, leading to the decrease of [Cl−]i and...
Genomes of unicellular and multicellular green algae, mosses, grasses and dicots harbor genes encoding cation-chloride cotransporters (CCC). CCC proteins from the plant kingdom have been comparatively less well investigated than their animal counterp...
The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secre...
The accurate determination of trace metals in aqueous matrices necessitates robust sample preparation techniques that enable selective preconcentration of analytes while ensuring compatibility with subsequent instrumental analysis. Dispersive solid-p...
The most prevalent chronic liver disorder in the world is fatty liver disease caused by a high-fat diet. We examined the effects of Lactiplantibacillus plantarum-KCC48 on high-fat diet-induced (HFD) fatty liver disease in mice. We used the transcript...
The early detection of Parkinson’s disease (PD) is a critical issue in terms of efficiency. Alpha-synuclein (α-Syn) is a biomarker in PD checks. Alpha-synuclein (α-syn) is the major constituent of Lewy bodies and a pathogenic hallma...
In the current study, Lactobacillus rhamnosus (KCC-51) and Lactobacillus paracasei (KCC-52) were isolated and investigated for their biological potential including antibacterial activity, probiotic potential, nutritional changes, fermentation ability...
Infectious diseases caused by bacteria are at risk of spreading and prolonging due to antimicrobial resistance. It is, therefore, urgently necessary to develop a more effective antibiotic alternative strategy to control pathogen spread. In general, p...
Water inrush disaster is one of the major disasters affecting the production safety of coal mines following roof caving, fire, gas outburst, and dust explosion disasters. It is urgent to reveal the water inrush mechanism and take effective measures t...
Premenstrual Dysphoric Disorder (PMDD) is a psychiatric condition characterized by debilitating affective symptomatology in the luteal phase of the menstrual cycle. Based on the previous reports that PMDD may be related to GABAergic cellular dysfunct...
Karst collapse columns (KCCs) are naturally formed geological structures that are widely observed in North China. Given their influence on normal mining operations and the progress of mining work, collapse columns pose a hidden danger in coal mining...
A large surface area dendritic mesoporous silica material (KCC-1) was successfully synthesized and used as a support to confine SnO2 nanoparticles (NPs). Owing to the large specific surface area and abundant mesoporous structure of dendritic KCC-1, t...
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