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Review

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

1
Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, Hatherly Laboratories, University of Exeter, Exeter EX4 4PS, UK
2
Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen 361004, Fujian, China
*
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2293; https://doi.org/10.3390/cells9102293
Received: 19 August 2020 / Revised: 8 October 2020 / Accepted: 14 October 2020 / Published: 14 October 2020
The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. The functions of CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells in addition to their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promotes the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings suggest hypothalamic signaling as a key signaling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs. View Full-Text
Keywords: cardiovascular disease; hypertension; atherosclerosis; electroneutral transport; cation-chloride-cotransporters; KCCs; NKCCs cardiovascular disease; hypertension; atherosclerosis; electroneutral transport; cation-chloride-cotransporters; KCCs; NKCCs
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MDPI and ACS Style

Meor Azlan, N.F.; Zhang, J. Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells 2020, 9, 2293. https://doi.org/10.3390/cells9102293

AMA Style

Meor Azlan NF, Zhang J. Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells. 2020; 9(10):2293. https://doi.org/10.3390/cells9102293

Chicago/Turabian Style

Meor Azlan, Nur Farah, and Jinwei Zhang. 2020. "Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease" Cells 9, no. 10: 2293. https://doi.org/10.3390/cells9102293

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