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  • Review
  • Open Access
92 Citations
8,383 Views
21 Pages

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

  • Gurleen Taggar,
  • Muhammad Attiq Rehman,
  • Patrick Boerlin and
  • Moussa Sory Diarra

The Enterobacteriales order consists of seven families including Enterobacteriaceae, Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and Budviciaceae and 60 genera encompassing over 250 species. The Enterobacteriaceae is cur...

(This article belongs to the Special Issue Carbapenemase-Producing Enterobacterales)
  • Article
  • Open Access
10 Citations
3,561 Views
14 Pages

In Vitro Activity of New β-Lactamase Inhibitor Combinations against blaNDM, blaKPC, and ESBL-Producing Enterobacteriales Uropathogens

  • Lubna Razaq,
  • Fakhur Uddin,
  • Shahzad Ali,
  • Shah Muhammad Abbasi,
  • Muhammad Sohail,
  • Nabila E. Yousif,
  • Hala M. Abo-Dief and
  • Zeinhom M. El-Bahy

25 September 2023

Antibiotic resistance in uropathogens has increased substantially and severely affected treatment of urinary tract infections (UTIs). Lately, some new formulations, including meropenem/vaborbactam (MEV), ceftazidime/avibactam (CZA), and ceftolozane/t...

(This article belongs to the Special Issue Uropathogens—Antibiotic Resistance and Alternative Therapies, 2nd Edition)
  • Review
  • Open Access
65 Citations
9,888 Views
18 Pages

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

  • Matteo Bassetti,
  • Antonio Vena,
  • Chiara Sepulcri,
  • Daniele Roberto Giacobbe and
  • Maddalena Peghin

22 September 2020

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechan...

(This article belongs to the Special Issue Gram-Negative Bloodstream Infections)
  • Article
  • Open Access
3 Citations
2,349 Views
17 Pages

Potential Involvement of Buchnera aphidicola (Enterobacteriales, Enterobacteriaceae) in Biotype Differentiation of Sitobion avenae (Hemiptera: Aphididae)

  • Yanyan Lan,
  • Jingpeng Li,
  • Shuo Zhang,
  • Qiuju Qin,
  • Deguang Liu,
  • Chen Luo,
  • Shipeng Han,
  • Da Wang and
  • Yunzhuan He

11 December 2024

Buchnera aphidicola, an obligate endosymbiont of most aphid species, can influence aphids’ host adaptability through amino acid metabolism, potentially mediating biotype differentiation. However, its role in the biotype differentiation of Sitob...

(This article belongs to the Special Issue Biology and Molecular Mechanisms of Plant-Aphid Interactions)
  • Communication
  • Open Access
12 Citations
3,128 Views
9 Pages

Synergistic Activity of Cefiderocol in Combination with Avibactam, Sulbactam or Tazobactam against Carbapenem-Resistant Gram-Negative Bacteria

  • Russell E. Lewis,
  • Marta Palombo,
  • Erica Diani,
  • Benedetta Secci,
  • Davide Gibellini and
  • Paolo Gaibani

6 August 2024

We investigated the activity of cefiderocol/β-lactamase inhibitor combinations against clinical strains with different susceptibility profiles to cefiderocol to explore the potentiality of antibiotic combinations as a strategy to contain the maj...

(This article belongs to the Special Issue Mechanisms of Antimicrobial Treatment in Human Diseases)
  • Article
  • Open Access
11 Citations
3,754 Views
11 Pages

First Detection of mcr-9 in a Multidrug-Resistant Escherichia coli of Animal Origin in Italy Is Not Related to Colistin Usage on a Pig Farm

  • Flavia Guarneri,
  • Cristina Bertasio,
  • Claudia Romeo,
  • Nicoletta Formenti,
  • Federico Scali,
  • Giovanni Parisio,
  • Sabrina Canziani,
  • Chiara Boifava,
  • Federica Guadagno and
  • Giovanni Loris Alborali
  • + 1 author

The emergence of colistin resistance raises growing concerns because of its use as a last-resort antimicrobial for the treatment of severe gram-negative bacterial infections in humans. Plasmid-borne mobile colistin resistance genes (mcr) are particul...

(This article belongs to the Special Issue Use of Antibiotics in Animals and Antimicrobial Resistance)
  • Article
  • Open Access
13 Citations
2,783 Views
8 Pages

14 November 2022

The management of KPC-producing K. pneumoniae (KPC-Kp) in bloodstream infections (BSIs) represent a serious clinical challenge. In this study, the aim is to assess the incidence of resistance to novel β-lactams-β-lactamase inhibitor combina...

(This article belongs to the Special Issue Multi-Drug Resistant Gram-Negative Infections: Molecular Epidemiology, Microbiological Diagnosis and Antimicrobial Treatment)
  • Article
  • Open Access
5 Citations
3,130 Views
14 Pages

Epidemiology of Antibiotic Resistant Pathogens in Pediatric Urinary Tract Infections as a Tool to Develop a Prediction Model for Early Detection of Drug-Specific Resistance

  • Francesca Bagnasco,
  • Giorgio Piaggio,
  • Alessio Mesini,
  • Marcello Mariani,
  • Chiara Russo,
  • Carolina Saffioti,
  • Giuseppe Losurdo,
  • Candida Palmero and
  • Elio Castagnola

Antibiotic resistance is an increasing problem, especially in children with urinary tract infections. Rates of drug-specific resistant pathogens were reported, and an easy prediction model to guide the clinical decision-making process for antibiotic...

(This article belongs to the Special Issue Global Spread of Antibiotics)
  • Article
  • Open Access
14 Citations
3,639 Views
15 Pages

The Bacterial Community Associated with the Amarillo Zamorano Maize (Zea mays) Landrace Silage Process

  • Humberto Ramírez-Vega,
  • Ramón I. Arteaga-Garibay,
  • Otoniel Maya-Lucas,
  • Victor M. Gómez-Rodríguez,
  • Ismael F. Chávez-Díaz,
  • José M. Ruvalcaba-Gómez,
  • Darwin Heredia-Nava,
  • Raquel Loperena-Martínez and
  • L. X. Zelaya-Molina

Maize silage is used in the diet of dairy cows, with suitable results in milk yield. In this study, the composition and diversity of the bacterial communities of the silage process of Amarillo Zamorano (AZ) Mexican maize landrace with relation to the...

(This article belongs to the Section Microbial Biotechnology)
  • Article
  • Open Access
23 Citations
5,044 Views
10 Pages

In Vitro Activity of Imipenem-Relebactam, Meropenem-Vaborbactam, Ceftazidime-Avibactam and Comparators on Carbapenem-Resistant Non-Carbapenemase-Producing Enterobacterales

  • Rémy A. Bonnin,
  • Sandrine Bernabeu,
  • Cécile Emeraud,
  • Thierry Naas,
  • Delphine Girlich,
  • Agnès B. Jousset and
  • Laurent Dortet

Background: Avibactam, relebactam and vaborbactam are β-lactamase inhibitors that proved their efficiency against KPC-producing Enterobacterales. Regarding their inhibitor activity towards Ambler’s class A extended spectrum β-lactamas...

(This article belongs to the Special Issue Bacterial Pathogenesis and Antimicrobial Strategy)
  • Article
  • Open Access
27 Citations
5,490 Views
14 Pages

20 August 2019

Psychrotrophic foodborne pathogens, such as enteropathogenic Yersinia, which are able to survive and multiply at low temperatures, require cold shock proteins (Csps). The Csp superfamily consists of a diverse group of homologous proteins, which have...

(This article belongs to the Section Molecular Microbiology)
  • Article
  • Open Access
100 Citations
17,928 Views
20 Pages

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

  • Amanda Cuevas-Sierra,
  • Fermín I. Milagro,
  • Paula Aranaz,
  • Jose Alfredo Martínez and
  • José I. Riezu-Boj

6 August 2021

Ultra-processed foods (UPFs) consumption could affect gut microbiota diversity and profile. We aimed to evaluate the effects of UPFs on microbiota, considering the role of sex. The consumption of UPFs (using NOVA criteria) was assessed with a validat...

(This article belongs to the Collection Connection between Microbiome, Lifestyle and Diet)
  • Article
  • Open Access
6 Citations
3,021 Views
18 Pages

Impact of On-Farm Interventions against CTX-Resistant Escherichia coli on the Contamination of Carcasses before and during an Experimental Slaughter

  • Michaela Projahn,
  • Jana Sachsenroeder,
  • Guido Correia-Carreira,
  • Evelyne Becker,
  • Annett Martin,
  • Christian Thomas,
  • Carolin Hobe,
  • Felix Reich,
  • Caroline Robé and
  • Niels Bandick
  • + 2 authors

24 February 2021

Cefotaxime (CTX)-resistant Enterobacteriaceae are still an ongoing challenge in human and veterinary health. High prevalence of these resistant bacteria is detected in broiler chickens and the prevention of their dissemination along the production py...

(This article belongs to the Special Issue Antimicrobial Resistance: From Farm to Fork)
  • Article
  • Open Access
9 Citations
3,286 Views
11 Pages

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci

  • Haixiao Jin,
  • Youhong Zhong,
  • Yiting Wang,
  • Chuanyu Zhang,
  • Jin Guo,
  • Xiaona Shen,
  • Cunxiang Li,
  • Ying Huang,
  • Haoming Xiong and
  • Wei Li
  • + 1 author

8 December 2022

Bacteriophages (phages) have been successfully used as disinfectors to kill bacteria in food and the environment and have been used medically for curing human diseases. The objective of this research was to elucidate the morphological and genomic cha...

(This article belongs to the Special Issue Bacteriophage Bioinformatics)
  • Article
  • Open Access
42 Citations
8,155 Views
15 Pages

15 May 2022

Royal jelly (RJ) is a natural bee product that contains a variety of biologically active ingredients and has antitumor, antiallergic, antibacterial and immune-regulating effects. Inflammatory bowel disease (IBD) is a chronic inflammatory disease of t...

(This article belongs to the Section Nutrition and Public Health)
  • Article
  • Open Access
7 Citations
3,247 Views
19 Pages

Comparison of the Peel-Associated Epiphytic Bacteria of Anthocyanin-Rich “Sun Black” and Wild-Type Tomatoes under Organic and Conventional Farming

  • Susanna Gorrasi,
  • Marcella Pasqualetti,
  • Barbara Muñoz-Palazon,
  • Giorgia Novello,
  • Andrea Mazzucato,
  • Enio Campiglia and
  • Massimiliano Fenice

Tomatoes are among the most consumed vegetables worldwide and represent a source of health-beneficial substances. Our study represents the first investigating the peel-associated epiphytic bacteria of red and purple (anthocyanin-rich) tomatoes subjec...

(This article belongs to the Special Issue Plant and Soil-Associated Microbial Communities in Forest and Agricultural Ecosystems 2.0)
  • Article
  • Open Access
10 Citations
2,797 Views
11 Pages

23 January 2023

Membrane bioreactors (MBR) have become prevalent in wastewater treatment because of their high effluent quality and low sludge generation. Sludge retention time (SRT) is an important parameter in the operation of MBR, and it has a direct effect on th...

(This article belongs to the Section Membrane Applications for Water Treatment)
  • Article
  • Open Access
38 Citations
5,764 Views
15 Pages

Seasonal Diversity of Endophytic Bacteria Associated with Cinnamomum camphora (L.) Presl.

  • Abubakr Abdelwhab Hamd Elmagzob,
  • Muhammed Mustapha Ibrahim and
  • Guo-Fang Zhang

15 July 2019

Investigations on the density, diversity, and distribution of endophytic bacterial community associated with leaves of Cinnamomum camphora (L.) Presl. were carried out during three seasons using 16s rDNA high-throughput sequencing technology. Samples...

(This article belongs to the Section Microbial Diversity and Culture Collections)
  • Article
  • Open Access
20 Citations
4,121 Views
21 Pages

Emodin Improves Intestinal Health and Immunity through Modulation of Gut Microbiota in Mice Infected by Pathogenic Escherichia coli O1

  • Ruijuan Gao,
  • Chunjie Wang,
  • Aricha Han,
  • Yanping Tian,
  • Shunan Ren,
  • Wenting Lv,
  • Aorigele Chen and
  • Jian Zhang

19 November 2021

The effect of emodin on the intestinal mucosal barrier of a mouse E. coli O1-induced diarrhea model was observed. Following successful establishment of a diarrhea model, the mice were treated with drugs for seven days. Intestinal lesions and the shap...

  • Article
  • Open Access
4 Citations
4,726 Views
17 Pages

The Gut Microbiota of the Egyptian Mongoose as an Early Warning Indicator of Ecosystem Health in Portugal

  • Mónica V. Cunha,
  • Teresa Albuquerque,
  • Patrícia Themudo,
  • Carlos Fonseca,
  • Victor Bandeira and
  • Luís M. Rosalino

The Egyptian mongoose is a carnivore mammal species that in the last decades experienced a tremendous expansion in Iberia, particularly in Portugal, mainly due to its remarkable ecological plasticity in response to land-use changes. However, this spe...

(This article belongs to the Special Issue Animals as Environmental Sentinels of Humans Infections)
  • Article
  • Open Access
2,057 Views
13 Pages

Changes in Microbiota Profile in the Proximal Remnant Intestine in Infants Undergoing Surgery Requiring Enterostomy

  • Inês Barreiros-Mota,
  • João R. Araújo,
  • Cláudia Marques,
  • Laura Sousa,
  • Juliana Morais,
  • Inês Castela,
  • Ana Faria,
  • Maria Teresa Neto,
  • Gonçalo Cordeiro-Ferreira and
  • Conceição Calhau
  • + 3 authors

Early-life gut dysbiosis has been associated with an increased risk of inflammatory, metabolic, and immune diseases later in life. Data on gut microbiota changes in infants undergoing intestinal surgery requiring enterostomy are scarce. This prospect...

(This article belongs to the Special Issue Gut Microbiome and Children’s Health)
  • Review
  • Open Access
97 Citations
16,193 Views
17 Pages

An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

  • Erlangga Yusuf,
  • Hannelore I. Bax,
  • Nelianne J. Verkaik and
  • Mireille van Westreenen

4 March 2021

Infections in the ICU are often caused by Gram-negative bacteria. When these microorganisms are resistant to third-generation cephalosporines (due to extended-spectrum (ESBL) or AmpC beta-lactamases) or to carbapenems (for example carbapenem producin...

(This article belongs to the Special Issue Update on Diagnostic, Antibiotic Treatment, and Prevention of Infections in Critically Ill Patients)
  • Article
  • Open Access
1,390 Views
17 Pages

5 November 2025

Semiaphis heraclei Takahashi (Hemiptera: Aphididae) serves as a vital resource for natural enemies from functional plant Cnidium monnieri (L.) Cusson (Apiaceae), playing a crucial role in ecological dynamics. Endosymbionts influence the performance o...

(This article belongs to the Special Issue Functional Plants for Ecological Control of Agricultural Pests)
  • Article
  • Open Access
16 Citations
6,552 Views
13 Pages

Isolation and Characterization of Extracellular Vesicles Secreted In Vitro by Porcine Microbiota

  • Leidy Lagos,
  • Sabina Leanti La Rosa,
  • Magnus Ø. Arntzen,
  • Ragnhild Ånestad,
  • Nicolas Terrapon,
  • John Christian Gaby and
  • Bjørge Westereng

The secretion of extracellular vesicles, EVs, is a common process in both prokaryotic and eukaryotic cells for intercellular communication, survival, and pathogenesis. Previous studies have illustrated the presence of EVs in supernatants from pure cu...

(This article belongs to the Special Issue Gut Microbiota Development in Farm Animals)
  • Article
  • Open Access
656 Views
23 Pages

Comparison of Environmental Microbiomes, Resistomes and Plasmidomes from a Human Tertiary Hospital and Companion Animal Veterinary Hospital in London, UK

  • Linzy Elton,
  • Stuart Lutimba,
  • Alonso Dupuy Mateos,
  • Siân Marie Frosini,
  • Rosanne Jepson,
  • Alan Williams,
  • Shanom Ali,
  • Jelena Heaphy,
  • Vicky Pang and
  • Emmanuel Q. Wey
  • + 13 authors

Background: Human hospitals and veterinary centres are hotspots for resistant microbes and plasmids, and metagenomic sequencing offers an agnostic insight into microbiomes, resistomes, and mobilomes, informing strategies for reducing AMR spread. Meth...

(This article belongs to the Special Issue Genomic Surveillance of Antimicrobial Resistance (AMR))
  • Article
  • Open Access
31 Citations
3,951 Views
9 Pages

Limited treatment options are among the main reasons why antimicrobial resistance has become a leading major public health problem. In particular, carbapenem-resistant Enterobacteriales (CRE), Pseudomonas aeruginosa and Acinetobacter baumannii have b...

(This article belongs to the Special Issue Novel Antimicrobial Strategies to Combat Multidrug-Resistant (MDR) Gram-Negative Bacteria)
  • Article
  • Open Access
2 Citations
2,592 Views
14 Pages

Characteristics of Gut Microbiome in the Murine Model of Pancreatic Cancer with Damp-Heat Syndrome

  • Yangbo Tong,
  • Fang Han,
  • Mengyao Liu,
  • Tianyu Xu,
  • Aiqin Zhang,
  • Jiangjiang Qin,
  • Yuhua Zhang and
  • Xiang Qian

Purpose: Murine models of pancreatic cancer with damp-heat syndrome were established based on two methods to explore the differences in the composition of intestinal flora and to seek characteristic genera with potential for model evaluation. Methods...

(This article belongs to the Section Molecular and Translational Medicine)
  • Article
  • Open Access
832 Views
16 Pages

Impact of Ocean Acidification on the Intestinal Microflora of Sinonovacula constricta

  • Yuan Wei,
  • Hesheng Dou,
  • Chengju Chai,
  • Tingkuan Wang,
  • Huiru Liu,
  • Shuang Liang,
  • Yongren Li,
  • Jian Liang and
  • Yongjun Guo

7 November 2025

The intestinal microflora, which is vital for nutrient absorption and immune regulation, can experience dysbiosis under environmental stress, potentially enhancing host susceptibility to pathogenic invasion. The impact of ocean acidification on bival...

(This article belongs to the Section Aquatic Invertebrates)
  • Article
  • Open Access
47 Citations
4,758 Views
16 Pages

Dietary Catalase Supplementation Alleviates Deoxynivalenol-Induced Oxidative Stress and Gut Microbiota Dysbiosis in Broiler Chickens

  • Weiwei Wang,
  • Jingqiang Zhu,
  • Qingyun Cao,
  • Changming Zhang,
  • Zemin Dong,
  • Dingyuan Feng,
  • Hui Ye and
  • Jianjun Zuo

28 November 2022

Catalase (CAT) can eliminate oxygen radicals, but it is unclear whether exogenous CAT can protect chickens against deoxynivalenol (DON)-induced oxidative stress. This study aimed to investigate the effects of supplemental CAT on antioxidant property...

(This article belongs to the Special Issue Novel Strategies for Biodegradation and Detoxification of Mycotoxins)
  • Review
  • Open Access
27 Citations
6,567 Views
34 Pages

Hidden Places for Foodborne Bacterial Pathogens and Novel Approaches to Control Biofilms in the Meat Industry

  • Virgínia Farias Alves,
  • Leonardo Ereno Tadielo,
  • Ana Carolina Moreira da Silva Pires,
  • Marita Gimenez Pereira,
  • Luciano dos Santos Bersot and
  • Elaine Cristina Pereira De Martinis

11 December 2024

Biofilms are of great concern for the meat industry because, despite the implementation of control plans, they remain important hotspots of contamination by foodborne pathogens, highlighting the need to better understand the ecology of these microeco...

(This article belongs to the Special Issue Novel Approaches for Controlling and Analyzing Microorganisms in Foods)
  • Article
  • Open Access
20 Citations
7,074 Views
15 Pages

Causal Effects of Gut Microbiota on Sleep-Related Phenotypes: A Two-Sample Mendelian Randomization Study

  • Min Yue,
  • Chuandi Jin,
  • Xin Jiang,
  • Xinxin Xue,
  • Nan Wu,
  • Ziyun Li and
  • Lei Zhang

12 September 2023

Increasing evidence suggests a correlation between changes in the composition of gut microbiota and sleep-related phenotypes. However, it remains uncertain whether these associations indicate a causal relationship. The genome-wide association study s...

(This article belongs to the Section Computational Models)