Sustainable Development Goal 3: Good Health and Well-Being (62688)

Objective: To determine the prevalence of and risk factors for congenital toxoplasmosis in neonates treated in the public health network of the eastern region of the Brazilian Amazon, northern Tocantins state. Methods: A retrospective cohort study was conducted with neonates born to mothers with gestational toxoplasmosis who received care between 2017 and 2024. The outcome under analysis was positivity for immunoglobulin M in the electrochemiluminescence assay (CLIA). We estimated the prevalence of transplacental infection and respective 95% confidence intervals (95% CI) and its association with risk factors using the odds ratio (or) with a p-value < 0.05 in infected neonates before and after 16 gestational weeks at maternal infection diagnosis. Results: A total of 1142 neonates were surveyed, in which 496 were diagnosed with congenital toxoplasmosis (IgM positive), thus obtaining a prevalence of vertical transmission of 45.4%. The main risk factors for vertical transmission were the mother’s education level equal to or less than eight years, (OR = 1.5; 95% CI 1.2; 2.0) and having less than six prenatal consultations (OR = 22.8; 95% CI 3.0; 172.6). Conclusions: A high prevalence of congenital toxoplasmosis was observed, with higher rates of infection in neonates born to mothers with lower levels of education. Full article

Rapid and effective clearance of apoptotic cells, known as efferocytosis, is essential for maintaining tissue homeostasis. Efferocytosis removes apoptotic cells before the occurrence of membrane rupture from which the cell contents, often inflammatory and toxic, are released into surrounding tissues. Through this way, efferocytosis protects the surrounding tissues from toxic enzymes and oxides inside the apoptotic cells as well as from cellular contents such as anti-proteinase and cystatins. Driven by the ongoing advancements in bioinformatics and molecular biology, many researchers have explored the mechanism of efferocytosis and its association with systemic diseases. Multiple studies have demonstrated that impaired efferocytosis mechanisms significantly contribute to the onset and progression of chronic inflammation. The presence of chronic inflammation significantly exacerbates the advancement of cardiovascular diseases, including atherosclerosis, myocardial infarction, heart failure subsequent to myocardial infarction, and even myocarditis. This review aims to provide a brief introduction to the mechanisms involved in cellular efferocytosis, followed by an examination of the molecular and pathway aspects of efferocytosis with the risk of cardiovascular diseases, contributing to the identification of potential therapeutic targets for related diseases. Full article

Monitoring trace metals in commercially important fish species provides an early warning of anthropogenic contamination and potential risk to consumers. This study semi-quantified and quantified essential, non-essential, and toxic elements in the muscle of wild meagre (Argyrosomus regius) captured in the Tagus estuary (Portugal), which is used as a nursery and spawning aggregation area. Dry muscle was microwave-digested and analyzed using inductively coupled plasma–optical emission spectroscopy. Semi-quantified screening detected Al, B, Ca, Fe, K, Mg, Na, P, S, Si, Sr, and Ti, and eight elements were determined using multielement calibration (As, Cr, Cu, Hg, Mn, Ni, Se, and Zn); Cd, Pb (toxic elements), Co, and Mo were not detected in this study. Arsenic was detected in all individuals, with a minimum value of 0.348 mg/kg wet weight. A mercury level above the European Commission regulatory limit (0.5 mg/kg wet weight) was only detected in one individual, corresponding to 2% of the samples. Although other metals remain well below regulatory limits, continued biomonitoring is recommended to track temporal trends and safeguard seafood safety in transitional coastal systems, which is important for commercially relevant fish species. Full article

Quantitative assessment of ecosystem health (EH) effectively provides a scientific reference for regional landscape ecological development and socio-ecological system coordination. This study combined the VORSH framework and the XGBoost-SHAP model to assess EH and its spatiotemporal driving factors in the Pinglu Canal Economic Zone. The results show that the comprehensive ecosystem health index (EHI) generally remained at a moderate level during this period, exhibiting a pattern of initial decline followed by recovery, resulting in an overall improving trend. The period from 2005 to 2010 was identified as a critical transitional phase, during which EH began to recover and gradually improve. The Pinglu Canal Economic Zone exhibits distinct spatial heterogeneity in EH. Areas with poor and unhealthy grades are primarily distributed around urban peripheries, plain regions, and near certain water bodies. In contrast, healthy and relatively healthy areas are predominantly located in the densely vegetated mountainous regions of the southwest, north, and east. Between 2000 and 2020, the EH status demonstrated a significant overall upward trend, with most areas experiencing slight improvement and only a few regions exhibiting significant degradation. Topography and temperature were the primary factors driving the spatiotemporal variations in EH, while the influence of human activities continued to intensify with ongoing socioeconomic development. Full article

Traffic police officers represent a critical occupational group with high vulnerability to vehicular air pollution, a severe environmental health threat in rapidly urbanizing metropolises such as Addis Ababa. This cross-sectional study explored occupational exposure, protective practices, health risks, perceptions, and awareness of air-quality-associated health risks among 120 traffic police officers in Addis Ababa. The officers were mostly male (80%) and married (93.3%), with the majority (62.6%) having served for more than ten years. While vehicle emissions were consistently recognized as the main source of air pollution, critical knowledge gaps were identified, i.e., only 24.2% had received pollution-related training, fewer than half (45.8%) were aware of government policies, and just 9.2% reported collaboration with environmental authorities. Awareness of the Air Quality Index (AQI) was generally low, and regular monitoring of AQI was limited. Self-reported health symptoms were highly prevalent among participants, with cough (75.0%), eye irritation (61.7%), sneezing (58.3%), and runny nose (55.8%) being the most frequently reported. Notably, sneezing, runny nose, eye irritation, and psychological stress showed significant association with perceived pollution levels at the workplace (p < 0.05), while blood pressure, cough, difficulty concentrating, and sleep loss were not significantly associated (p > 0.05). A higher prevalence of symptoms was generally observed in groups experiencing moderate-to-very high levels of pollution. Protective measures were applied inconsistently; while 63.3% of participants reported using masks, their beliefs about the effectiveness of using masks varied. Relocation (60%) and use of face covers/glasses (13.3%) were less commonly practiced. Overall, traffic police officers are exposed to occupational air pollution, which is associated with various health symptoms. These findings highlight the need for enhanced training, clearer communication of policies, stronger institutional engagement, the provision of standardized protective masks, and the promotion of AQI utilization to reduce occupational health risks and safeguard the wellbeing of traffic police officers in Addis Ababa. Full article

Magnetic Barkhausen noise (MBN) represents a powerful non-destructive testing and material characterization methodology enabling quantitative assessment of microstructural features, mechanical properties, and stress states in ferromagnetic materials. This comprehensive review synthesizes recent advances spanning theoretical foundations, sensor design, signal processing methodologies, and industrial applications. The physical basis rooted in domain wall dynamics and statistical mechanics provides rigorous frameworks for interpreting MBN signals in terms of grain structure, dislocation density, phase composition, and residual stress. Contemporary instrumentation innovations including miniaturized sensors, multi-parameter systems, and high-entropy alloy cores enable measurements in challenging environments. Advanced signal processing techniques—encompassing time-domain analysis, frequency-domain spectral methods, time–frequency transforms, and machine learning algorithms—extract comprehensive material information from raw Barkhausen signals. Deep learning approaches demonstrate superior performance for automated material classification and property prediction compared to traditional statistical methods. Industrial applications span manufacturing quality control, structural health monitoring, railway infrastructure assessment, and predictive maintenance strategies. Key achievements include establishing quantitative correlations between material properties and stress states, with measurement uncertainties of ±15–20 MPa for stress and ±20 HV for hardness. Emerging challenges include standardization imperatives, characterization of advanced materials, machine learning robustness, and autonomous system integration. Future developments prioritizing international standards, physics-informed neural networks, multimodal sensor fusion, and wireless monitoring networks will accelerate industrial adoption supporting safe, efficient engineering practice across diverse sectors. Full article

Tropaeolum majus L. is a popular ornamental plant. All parts of T. majus plant (flowers, leaves, and seeds) are edible and are appreciated for their pungent taste, although their chemical composition varies. T. majus is known for its many health benefits. It is a source of trace elements and bioactive compounds that are easily absorbed by the human body. The flowers of T. majus contain flavonoids from the flavone and flavonol groups, as well as their glycosides, which exhibit antibacterial, antifungal and antiviral activity. They also inhibit the activity of certain enzymes. Among the flavonoids, the flowers and leaves of T. majus contain derivatives of kaempferol and quercetin. Flavonoids also include anthocyanins, which are responsible for the color of T. majus flowers. In red flowers, delphinidin predominates; in orange flowers, pelargonidin; and in yellow flowers, pelargonidin and delphinidin are present in similar amounts. In the flowers of T. majus, seven carotenoids have been identified: violaxanthin, antheraxanthin, lutein, zeaxanthin, α, β and γ-carotene. In the leaves, however, lutein, violaxanthin, β-carotene and neoxanthin were detected. In T. majus, the presence of two glucosinolates has been reported: glucotropaeolin and sinalbin. The flowers and leaves of T. majus also contain both macroelements (N, P, K, Ca, Mg, Na) and microelements (Fe, Mn, Cu, Zn, Mo), and essential oils which have anti-cancer, antibacterial, and antiviral properties. The quality and flowering of T. majus are enhanced by fungi of the Trichoderma genus, which is important both ecologically and in terms of increasing the yield of raw material extracted from the plant. T. aureoviride, T. hamatum, and T. harzianum stimulated the flowering of the T. majus ‘Spitfire’. The plants treated with T. harzianum after being planted in pots flowered the most abundantly. Trichoderma spp. caused the plants to grow more intensively, producing longer and more leafy shoots with a greater number of offshoots. Trichoderma spp. stimulated the uptake of macronutrients, except for P. In the case of Ca and Na, this phenomenon was only observed in plants treated with T. aureoviride and T. hamatum, and for Mg, only when T. hamatum was applied to sown seeds. As for the developed root systems, as far as the micronutrients are concerned, Trichoderma spp. stimulated the uptake of Zn and Mn. Additionally, there was a higher Fe content in the plants treated with T. harzianum on both dates and T. aureoviride after planting the plants in pots. Full article

Anomaly detection and degradation trend prediction are two pivotal tasks in system health management. However, most existing approaches treat them as independent problems and fail to exploit their intrinsic interdependence. In addition, the scarcity of labeled data in real-world scenarios limits the applicability of supervised learning methods. To address these challenges, we propose an adaptive thresholding strategy framework for unsupervised joint anomaly detection and trend prediction. Our framework introduces a self-adaptive threshold strategy from historical data distributions and dynamically updates them in response to evolving system behavior. The anomaly detection results are integrated to enhance degradation trend forecasting, while the predicted degradation trends, in turn, refine the anomaly thresholds through a feedback mechanism. Experiments on both public and real-world industrial datasets demonstrate that the proposed framework achieves superior detection accuracy, robust trend prediction, and high computational efficiency under diverse operational conditions. Full article

Urban and population densification have resulted in deteriorating living conditions for populations and the loss of UGSs. The COVID-19 pandemic has exposed the social, economic and environmental vulnerabilities of our societies, but it has also demonstrated the importance of UGSs as intrinsic elements for maintaining the quality of life of the population and making urban spaces sustainable. Due to its considerable area of UGS, the district of Benfica in Lisbon, Portugal, is the object of study. The study focuses on understanding how the proximity of UGS influences the practice of leisure activities for different publics, and how they are reflected in the populations’ lives, exploring the context during the COVID-19 pandemic. It develops a methodology with a mixed-methods approach: (1) literature review, policies, and urban planning; (2) observation methods, mapping and spatial analysis of UGS types; and (3) surveys. The empirical results indicate the importance of proximity to improve the frequency, namely for the elderly and children. The results also demonstrate that the quality (infrastructure and equipment) of UGS, despite having less walking proximity, is an important element to attract people to use the UGS. A general conclusion is that the proximity and accessibility (walking or public transport) are interlinked in both profiles of UGS, demonstrating a relationship between the place of residence, easy access and frequency of UGS in the practice of activities and the self-assessed physical and mental health benefits. Full article

Background/Objectives: Viral hepatitis remains a significant global cause of chronic liver disease, highlighting the importance of effective vaccination strategies. This review assesses recent evidence on vaccine safety and effectiveness. Methods: A comprehensive search of PubMed, Embase, Web of Science, and Scopus identified English-language studies published from January 2000 to September 2025. Eligible studies evaluated vaccination for hepatitis A, B, C, or E, as well as vaccine responses in individuals with chronic liver disease or HIV infection. Of 5254 records screened, 166 studies met the inclusion criteria. Results: Hepatitis A vaccines demonstrated excellent safety, 95–100% short-term seroprotection, and durable immunity for both inactivated and live-attenuated formulations, with population-level reductions in disease incidence. Hepatitis B vaccines showed consistently strong immunogenicity across age groups, with over 90% seroprotection from recombinant and CpG-adjuvanted formulations. Effective prevention of mother-to-child transmission required maternal antiviral therapy, timely birth-dose vaccination, hepatitis B immunoglobulin (HBIG) administration, and post-vaccination serologic testing. Long-term data demonstrated immune persistence for up to 35 years and significant reductions in liver cancer following neonatal HBV vaccination. Limited studies in hepatitis C populations showed impaired responses, partially improved with higher or booster doses. Hepatitis E vaccines showed excellent safety and over 99% seroconversion. In non-viral liver disease and post-transplant populations, vaccine responses were reduced but remained clinically meaningful, especially with adjuvanted or higher-dose HBV vaccines. Among HIV-infected individuals, HAV vaccination was generally effective, while enhanced HBV regimens markedly improved seroprotection. Conclusions: Hepatitis A, B, and E vaccines are safe, immunogenic, and effective, with neonatal hepatitis B vaccination critical for preventing maternal transmission. No licensed HCV vaccine exists, and therapeutic HCV vaccines show limited efficacy. Optimized and targeted vaccination strategies are needed for individuals with chronic liver disease, HIV infection, HCV infection, transplant recipients, and other immunocompromised populations to maximize public health impact. Full article

Caregiving for visually impaired individuals imposes substantial psychological, social, and financial burdens. This study examined depressive symptoms among family caregivers in rural Limpopo, South Africa, and their associations with sociodemographic and socioeconomic factors. A cross-sectional survey was conducted among 253 informal caregivers (response rate: 85.5%). Data on age, gender, marital status, education, employment, income, and socioeconomic status were collected. Depressive symptoms were assessed using the full 20-item Centre for Epidemiologic Studies Depression Scale (CES-D), and associations were analysed using chi-square tests, Cramer’s V, and logistic regression. Moderate-to-severe depressive symptoms were reported by 29.2% of caregivers, with 28.1% experiencing mild-to-moderate symptoms. Male caregivers were less likely to report minimal symptoms (OR = 0.3; 95% CI: 0.12–0.65). Caregivers aged 50–59 years were more likely to report lower depressive symptoms (OR = 1.3). Unmarried caregivers had higher odds of depressive symptoms compared with married caregivers (OR = 2.3). Education was protective: secondary education was associated with lower odds of severe symptoms, while primary education significantly increased risk (OR = 18.1). Lower-income caregivers tended to report higher depressive symptoms. Depressive symptoms among caregivers are influenced by gender, age, marital status, education, and income. Interventions such as psychosocial support, financial assistance, and community-based respite services are essential to reduce caregiver burden. Full article

The three key design criteria for nearly zero-energy buildings (nZEBs) and climate-neutral buildings are minimizing energy use, ensuring high occupant comfort, and reducing environmental impact. Thermal comfort is one of the main components of indoor environmental quality (IEQ), strongly affecting occupants’ health, well-being, and productivity. As energy-efficiency requirements become more demanding, the appropriate selection of heating systems, their automated control, and the management of solar heat gains are becoming increasingly important. This study investigates the influence of two low-temperature radiant heating systems—underfloor and wall-mounted—and the use of Venetian blinds on perceived thermal comfort in a highly glazed public nZEB building located in a densely built urban area within a temperate climate zone. The assessment was based on the PMV (Predicted Mean Vote) index, commonly used in IEQ research. The results show that both heating systems maintained indoor conditions corresponding to comfort or slight thermal stress under steady state operation. However, during periods of strong solar exposure in the room without blinds, PMV values exceeded 2.0, indicating substantial heat stress. In contrast, external Venetian blinds significantly stabilized the indoor microclimate—reducing PMV peaks by an average of 50.2% and lowering the number of discomfort hours by 94.9%—demonstrating the crucial role of solar protection in highly glazed spaces. No significant whole-body PMV differences were found between underfloor and wall heating. Overall, the findings provide practical insights into the control of thermal conditions in radiant-heated spaces and highlight the importance of solar shading in mitigating heat stress. These results may support the optimization of HVAC design, control, and operation in both residential and non-residential nZEB buildings, contributing to improved occupant comfort and enhanced energy efficiency. Full article

Background/Objectives: Sexual health is shaped by lifestyle factors alongside biomedical determinants. This review synthesises evidence on physiotherapy, balneology/peloidotherapy, and diet therapy as preventive and therapeutic adjuncts for female sexual dysfunctions and related gynaecological conditions. Methods: A structured narrative review of PubMed and Google Scholar (June–July 2025) was conducted by three independent reviewers using predefined keywords in English and Polish. Case reports, preprints, and studies before 2015 were excluded. From 7322 records, 47 studies met the inclusion criteria for qualitative synthesis. Results: Physiotherapy—particularly pelvic floor muscle training, multimodal manual therapy, neuromuscular electrical stimulation (including PTNS), magnetostimulation, short-wave diathermy, and capacitive–resistive monopolar radiofrequency—was consistently associated with reductions in dyspareunia, chronic pelvic pain, and urinary symptoms, with parallel improvements in sexual function and quality of life. Balneological procedures (brine baths/irrigations, crenotherapy, selected radon/sulphide/iodine–bromine applications) and peloidotherapy demonstrated analgesic, anti-inflammatory, and perfusion-enhancing effects, with signals of benefit in vulvodynia, endometriosis, and infertility support. Dietary measures—higher fruit intake (notably citrus), adequate vitamin D, targeted omega-3 use in PCOS, a Mediterranean dietary pattern, and prudent red-meat limitation—were associated with favourable endocrine–metabolic profiles and, in selected contexts, reduced disease risk. Conclusions: Integrating lifestyle–medicine modalities with standard care may meaningfully prevent and manage female sexual dysfunctions by addressing pain, perfusion, neuromuscular control, and endocrine–metabolic drivers. Implementation frameworks and high-quality trials are warranted to refine indications, dosing, and long-term effectiveness. Full article

The global literature underscores a set of human wellbeing challenges and opportunities for forestland exploitation, albeit the lack of region-specific evidence. This concerns the Congo Basin, the second-largest forest ecosystem in the world. This study uses the case of the Campo Ma’an Landscape to: (i) analyze the challenges linked to the exploitation of forestland resources, and (ii) explore forest resource exploitation opportunities in the landscape. The study employed a random sample of 200 natural resource-dependent households drawn from four study zones—Niete, Campo, Ma’an and Akom II. This was complemented by focus group discussions (n = 4), key informant (n = 6) and expert (n = 6) interviews. The descriptive and inferential analyses led to the following results: First, economic, technical, socio-cultural and institutional challenges affect the sustainable exploitation of forestland resources in the Campo Ma’an Landscape. The economic challenges of forest (B = −0.389, p = 0.01) and land resource exploitation (B = −0.423, p = 0.006) significantly affect sustainable exploitation compared to other challenges, leading to biodiversity loss and deforestation. These constitute a threat to planetary health systems. Almost all households rely on forestland resources for their livelihoods and development, with opportunities for land resource exploitation outweighing those in forest resource exploitation. Protected area management and agriculture are affected owing to competing interests among farmers, conservationists and other land users. Thus, short-term economic gains are prioritized over long-term sustainability, putting the resource landscape at risk of degradation and future uncertainties. Integrated stakeholder engagement, capacity building, and policy revision could enhance the planetary health approach by linking the social, economic and environmental dimensions of forestland resource management. Full article

The growing prevalence of anxiety, depression, and stress among students highlights the urgent need for school-based strategies that promote psychological well-being and timely intervention. This study explores the use of artificial intelligence (AI) as a scalable and data-driven tool to support institutional mental health initiatives in higher education. Using synthetic and real datasets derived from validated psychometric instruments (the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the Perceived Stress Scale (PSS-14)), we trained and evaluated 32 deep neural network architectures for the early detection of emotional distress. Optimized three- and four-layer dense models achieved classification accuracies exceeding 95%, demonstrating the feasibility of deploying AI-based screening tools in educational settings. Beyond prediction, this approach can support counselors and educators in identifying at-risk students and informing proactive, school-based interventions to improve mental health and resilience in post-pandemic academic environments. Full article

Resistance to conventional antibiotics remains a global health challenge. The search for more effective antimicrobial agents has led to the consideration of nanoparticles due to their potential biocidal activities. This study synthesized, characterized, and evaluated the antimicrobial behavior of cadmium sulfide nanoparticles (CdS NPs) during incubations at 37 °C and at room temperature (rt; 23 to 27 °C). XRD results showed that the synthesized nanoparticles had a cubic zinc blende structure, while microscopic investigations confirmed the particle size to be 7.236 nm on average. UV-Vis spectroscopy showed that the nanoparticles are active in the visible light region. Raman spectroscopy results showed peaks at 302.3 cm⁻¹ and 601 cm⁻¹, which represent the first- and second-order longitudinal optical phonon. Agar well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays were conducted to investigate the antimicrobial activity of CdS NPs (50 mg/mL, 25 mg/mL, and 10 mg/mL) against Escherichia coli and Staphylococcus aureus. CdS NPs were effective against both test organisms. However, they were more effective against Gram-negative E. coli. The higher the concentration of CdS NPs, the more effective they were against the test organisms. Furthermore, MBC results showed greater bactericidal activity of CdS NPs at 37 °C. With increasing incidences of antimicrobial resistance against conventional antimicrobial agents, especially in wastewater treatment, nanoparticles are considered promising alternatives and the next generation of antimicrobial agents. Full article

It is imperative that society becomes aware of ergonomic risks, not only in an occupational place but also in everyday contexts where they can go unnoticed, such as the educational sector, and in the specific case of students. To identify this risk, an ergonomic assessment was conducted on students in Mexico during remote learning due to COVID-19. To this end, a survey was applied, and the ROSA (Rapid Office Strain Assessment) method was used. According to the survey results, the students reported adopting inappropriate postures during online classes and suffering from musculoskeletal pains. Furthermore, they showed a strong interest in learning about ergonomics and improving their postures. In addition, the application of the ROSA method yielded a significant result 60% of the evaluated students are at high or very high ergonomic risk. Regardless of their profession, ergonomics should be integrated as part of educational programs. This measure would help prevent musculoskeletal disorders once students transition into their respective work environments. Full article

The design of smart skin with lightweight requirements utilizes high-performance composite materials, resulting in thin structural characteristics. When subjected to complex aerodynamic loads, the smart skin structure experiences warping deformation, which significantly impacts both flight efficiency and structural integrity. However, this deformation behavior has been largely overlooked in current shape sensing methods embedded within the structural health monitoring (SHM) systems of smart skin, leading to insufficient monitoring capabilities. To address this issue, this paper proposes a novel shape sensing methodology for the real-time monitoring of warping deformation in smart skin. Initially, the structural displacement field of the smart skin and the warping function are mathematically defined, incorporating constitutive relations and considering the influence of material parameters on sectional strains. Subsequently, the inverse finite element method (iFEM) is employed to establish a shape sensing model. The interpolation function and the actual sectional strains, derived from discrete strain measurements, are calculated based on the current constitutive equations. Finally, to validate the accuracy of the proposed iFEM for monitoring warping deformation, numerical tests are conducted on curved skin structures. The results indicate that the proposed methodology enhances reconstruction capability, with a 10% improvement in accuracy compared to traditional iFEM methods. Consequently, the shape sensing algorithm can be seamlessly integrated into the SHM system of smart skin to ensure the predicted performance. Full article

Background/Objectives: Incretin-based medications have transformed obesity management by enabling substantial body weight reduction. However, the rapid and pronounced loss of body mass necessitates a comprehensive, multidisciplinary approach incorporating nutritional and physical activity strategies to preserve lean mass, optimize functional outcomes, and prevent long-term complications. This narrative review provides a critical overview of this emerging clinical concern, which is expected to gain increasing relevance in the coming years. Methods: A literature review was conducted up to 31 October 2025, focusing on studies addressing nutritional, physical activity, and adjunctive interventions in adults with obesity treated with incretin-based medications. Results: Incretin-based agents induce significant weight loss, comparable to bariatric surgery, predominantly targeting adipose tissue. Nevertheless, these medications also cause rapid reductions in muscle and bone mass, often accompanied by nutrient deficiencies, which may compromise metabolic health and physical function. Tailored nutritional strategies—including hypocaloric diets enriched in protein and fiber, as well as amino acid, vitamin, and mineral supplementation—are critical to preserve lean mass and support sustained weight maintenance. Concurrently, structured, supervised physical activity, encompassing aerobics, resistance, and strength training, mitigates muscle loss and enhances functional capacity. Emerging pharmacological agents designed to promote adipose tissue reduction while preserving lean mass, as well as interventions targeting gut microbiota modulation, may represent promising adjunctive strategies to optimize long-term outcomes further. Conclusions: While incretin-based medications produce substantial weight loss, their impact on lean mass underscores the necessity of integrating personalized nutrition, supplementation, and structured exercise to preserve muscle, prevent malnutrition, and optimize long-term health and obesity outcomes. Full article

Micronutrient malnutrition persists as a global health burden, while conventional biofortification approaches suffer from low efficiency and environmental trade-offs. This study aimed to develop and evaluate a foliar-applied selenium–zinc nanocomposite (Nano-ZSe, a mixture of zinc ionic fertilizer and nano selenium) for synergistic Se/Zn co-biofortification in Brassica chinensis L., using a controlled pot experiment that integrated physiological, metabolic, molecular, and rhizosphere analyses. Application of Nano-ZSe at 0.18 mg·kg⁻¹ (Based on soil weight) not only increased shoot biomass by 28.4% but also elevated Se and Zn concentrations in edible tissues by 7.00- and 1.66-fold (within the safe limits established for human consumption), respectively, compared to the control. Mechanistically, Nano-ZSe reprogrammed the ascorbate-glutathione redox system and redirected carbon flux through the tricarboxylic acid cycle, suppressing acetyl-CoA biosynthesis and reducing abscisic acid accumulation. This metabolic rewiring promoted stomatal opening, thereby enhancing foliar nutrient uptake. Simultaneously, Nano-ZSe triggered the coordinated upregulation of BcSultr1;1 (a sulfate/selenium transporter) and BcZIP4 (a Zn²⁺ transporter), enabling synchronized translocation and the tissue-level co-accumulation of Se and Zn. Beyond plant physiology, Nano-ZSe improved soil physicochemical properties, enriched rhizosphere microbial diversity, and increased crop yield and economic returns. Collectively, this work demonstrates that nano-enabled dual-nutrient delivery systems can bridge nutritional and agronomic objectives through integrated physiological, molecular, and rhizosphere-mediated mechanisms, offering a scalable and environmentally sustainable pathway toward functional food production and the mitigation of hidden hunger. Full article

Background: Evidence suggests that physical activity and fitness tend to decline during the transition to higher education, yet the influence of institutional environment on these variables remains unclear. Objectives: This study aimed to compare physical fitness and physical activity levels between first-year students from two higher education institutions within the same national context. Methods: Fifty-eight male university students (IPB (Instituto Politécnico de Bragança): n = 31; IPG (Instituto Politécnico da Guarda): n = 27; mean age IPB = 19.2 ± 1.8 years; IPG = 19.8 ± 5.5 years) were assessed for body composition, handgrip strength, mid-thigh pull, standing long jump, stork balance, flexibility, and estimated VO_2max (StepTest4all). Physical activity levels were determined using the International Physical Activity Questionnaire (IPAQ) and were classified as low, moderate, or high. Between-group comparisons were performed using independent samples t-tests, with statistical significance set at p < 0.05. Results: Students from IPB presented significantly higher IPAQ scores (2.97 ± 0.18) compared with those from IPG (2.56 ± 0.64; t = 3.235, p = 0.003, d = 0.90), along with superior standing long jump performance (1.95 ± 0.15 m vs. 2.12 ± 0.24 m; t = −3.239, p = 0.002, d = 0.85). No significant differences were observed for body composition, strength, flexibility, balance, psychological well-being or VO_2max (all p > 0.05), although small effects were noted for flexibility (d = 0.50) and VO_2max (d = 0.48). The distribution of physical activity categories revealed that 96.8% of IPB students were classified as highly active, whereas IPG students were more evenly distributed across high (63.0%), moderate (28.6%), and low (7.4%) activity levels. Conclusions: These findings indicate that institutional environment and access to exercise opportunities may influence physical activity behavior and lower-limb power in university students. Promoting structured physical activity programs and recreational opportunities within higher education may help sustain adequate fitness and health in this population. Full article

Background: Hypermobile Ehlers–Danlos Syndrome (hEDS) results in multiple, complex health-related risks and associated fear of movement (kinesiophobia). Therefore, the purpose of this research study was to examine how a holistic, embodied, and performative movement program (EDS-HEART) can affect body schema, physical and mental health, and lifestyle, which contribute to the joy of movement and physical activity participation among adult women with hEDS. Methods: This was a hermeneutic, phenomenological, quasi-experimental, and community-based research study among six women with hEDS, who participated in the EDS-HEART movement program at a local physical therapy clinic. The seven-week program incorporated stretching and strength training activities as well as performative-thematic movement sequences. Results: Based on the qualitative analysis, three themes emerged regarding reasons for the joy of the EDS-HEART program: (a) improved body schema: body awareness, confidence, posture, and proprioception; (b) highly motivating program: holistic, embodied, performative, pleasant, and safe; and (c) psychosocial reasons: supportive setting, sense of pleasure and euphoria, and freed from social comparisons and the fear of movement. Conclusions: Based on the study results, public health experts should develop and implement easily accessible and holistic movement programs among people with hEDS and similar conditions to improve physical health, psychosocial health, and the joy of movement. Full article

Despite being key partners in the supportive care of the cancer patient, family caregivers are often inadequately prepared for or supported to take on this critical role, subsequently putting their own wellbeing at risk and, by extension, that of the patient. Exercise interventions show promise in mitigating caregiver burden and improving health outcomes for both caregivers and patients; however, the interrelationship between family caregiver and care recipient has gone largely unexplored. Thus, we conducted a single-group pilot study to examine the feasibility and preliminary effectiveness of a 12-week dyadic exercise intervention. Of the 27 caregiver–patient dyads who consented, 21 (77.8%) completed the study, with participants completing an average of 23.1 (96.3%) of the prescribed exercise sessions, suggesting good adherence and study retention. All participants reported higher post-intervention levels of strenuous physical activity (p = 0.017), improved sit-to-stand repetitions (p = 0.004), and social functioning (p = 0.030) compared to baseline. Of note, caregivers reported higher post-intervention scores on the burden in relationship subscale of the Zarit Burden Interview relative to baseline (p = 0.043), suggesting an increase in perceived caregiver burden following the intervention. Overall, dyadic exercise interventions appear feasible and may confer certain physical and psychosocial benefits for both family caregivers and care recipients. However, such programs may also unintentionally exacerbate certain aspects of caregiver burden. Future research should aim to identify factors within dyadic exercise interventions that may contribute to increased caregiver burden, as well as strategies to help mitigate these effects. Full article

Background: Testicular dysgenesis syndrome (TDS) is a complex disorder of the male reproductive system related to disfunction of the fetal testis. The clinical features of TDS may be evident at birth or infancy (cryptorchidism, hypospadias and/or reduced anogenital distance) or occur later in adulthood (testis cancer, infertility). Genetic background seems to be important for genetic predisposition, with new genes being associated with components of the syndrome in last years. Interestingly, the incidence of clinical manifestations of TDS has been increasing in many countries in recent decades, suggesting that genetic predisposition alone cannot explain this trend. Consequently, the hypothesis of multifactorial etiopathogenesis is becoming increasingly accepted nowadays, with environmental factors probably acting during early developmental stages in genetically predisposed individuals. Methods: In this narrative review, we aim to critically evaluate genetic and non-genetic factors involved in the pathogenesis of TDs. Results: Important associations with intrauterine growth disorders and maternal diseases (overweight/obesity and diabetes) as well as lifestyle factors (e.g., smoking and alcohol abuse) were found. In such context, endocrine disruptors probably play a major role. These substances are widely used in industry and can exert estrogenic and antiandrogenic effects, potentially interfering with the development of the fetal gonad. Conclusions: Considering their possible impact on male sexual health, more attention should be focused on maternal modifiable factors to confirm with prospective studies the mixed results of available evidence. Full article

The Internet of Medical Things (IoMT) interconnects medical devices, software applications, and healthcare services through the internet to enable the transmission and analysis of health data. IoMT facilitates seamless patient care and supports real-time clinical decision-making. The IoMT faces substantial security threats due to limited device resources, high device interconnectivity, and a lack of standardization. In this paper, we present an Intrusion Detection System (IDS) called An Empirical Distribution Ranking-Based Fuzzy J48 Classifier for Multiclass Intrusion Detection in IoMT Networks (EDR-FJ48) to distinguish between regular traffic and multiple types of security threats. The proposed IDS is built upon the J48 decision tree algorithm and is designed to detect a wide range of attacks. To ensure the protection of medical devices and patient data, the system incorporates a fuzzy IF-THEN rule inference module. In our approach, fuzzy rules are formulated based on the fuzzified values of selected features, which capture the statistical behavior of the input observations. These rules enable interpretable and transparent decision-making and are applied before the final classification step. We thoroughly evaluated our methodology through extensive simulations using three publicly available datasets, such as WUSTL-EHMS-2020, CICIoMT2024, and ECU-IoHT. The results exhibit exceptional accuracy rates of 99.68%, 98.71%, and 99.43%, respectively. A comparative analysis against state-of-the-art models in the existing literature, based on metrics including accuracy, precision, recall, F1-score, and time complexity, reveals that our proposed method achieves superior results. This evidence suggests that our method constitutes a robust solution for mitigating security threats in IoMT networks. Full article

A considerable number of people are exposed to noise from military aircraft daily, but its health effects have not been sufficiently examined. This study assessed the association of exposure to such noise with mental well-being and sleep disturbance among people living in Okinawa prefecture, where there are two U.S. military air bases. In 2024, data were collected from 394 residents in high-, low-, and no-exposure communities using the WHO-5 Well-being Index and the Athens Insomnia Scale. Among respondents, 55.8% were female; the largest age groups were 70’s (25.4%) and 60’s (23.6%). Poor mental well-being and sleep disturbance were most prevalent in the high-exposure community (poor mental well-being: 38.2%, sleep disturbance: 46.6%), followed by low-exposure (36.1%, 46.3%) and no-exposure (21.9%, 29.0%) communities. Multivariate logistic regression analyses showed that compared to no-exposure community, the high-exposure and low-exposure communities were significantly more likely to have poor mental well-being (odds ratio (OR): 1.84, 95% confidence interval (CI): 1.05–3.23; OR: 1.94, 95% CI: 1.05–3.56), as well as sleep disturbance (OR: 1.98, 95% CI: 1.17–3.35; OR: 2.04; 95% CI: 1.16–3.59, respectively). The results suggest that there is a substantial need to address the noise from military aircraft in Okinawa. Full article

Acculturation and social networks shape ideals of weight perception, given that the construct is steeped in cultural perceptions of beauty and norms. This study leverages social network data from New York City (n = 80_participants; 1600_{network members}) who were asked “Would you like to weigh more, less, or stay the same?” as well as questions regarding their acculturation stress levels and the perceived weight of social network members. Body Mass Index (BMI) was objectively measured. Regression models evaluated the association between BMI, weight satisfaction, and acculturation stress, net of sociodemographic variables, weight loss attempts, and health behaviors. Those who were dissatisfied with their weight and experienced high acculturation stress had a significantly higher BMI (β = 5.4, 2.8–8.1, p < 0.001) in the fully adjusted model. However, with every 25% increase in the perception of network members with obesity/overweight, there was a significant decrease in individual BMI. No other social network variables were significantly associated with BMI. More research is needed among Latinos/as across the acculturative stress spectrum to fully understand how social norms regarding weight affect both social networks and individuals, as well as how these might be influenced by cross-cultural differences between US and Latino/a norms regarding ideal weight perceptions. Full article

The Infectious Diseases Society of America (IDSA) guidelines for community-acquired pneumonia (CAP) recommend pneumococcal urinary antigen testing (UAT) for a subset of inpatients admitted with pneumonia. Despite this, UAT testing is frequently performed on inpatients who do not meet the official IDSA criteria, and current evidence regarding antibiotic de-escalation in UAT-positive cases remains inconclusive. To explore this further, we conducted a retrospective cohort study examining antibiotic de-escalation patterns among hospitalized CAP patients who underwent UAT over a 60-day period during peak respiratory illness season (November and December, 2023). Patients with positive UAT results were compared to those who had negative UAT; the primary outcome was whether a positive UAT impacted antibiotic de-escalation prescribing. A total of 268 patients were analyzed—235 UAT-negative and 33 UAT-positive. Both groups were comparable in terms of disease severity, underlying health conditions, and readmission rates. Empiric therapy targeting Pseudomonas aeruginosa (P. aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA) was used in 40% of patients (36% in the UAT-positive group and 46% of the UAG-negative group). The use of atypical coverage, MRSA coverage, or anti-pseudomonal β-lactams was frequently de-escalated in both cohorts (p < 0.05); however, the UAT-positive group had significantly shorter durations of anti-pseudomonal therapy (p = 0.03) and anti-MRSA therapy (p = 0.02). Despite this, the UAT-positive group was more commonly given fluoroquinolones, such as levofloxacin or moxifloxacin, over narrow-spectrum β-lactams for final antibiotic coverage (p = 0.021). Overall, positive UAT appeared to support earlier discontinuation of anti-MRSA and anti-pseudomonal antibiotics; however, it did not impact fluoroquinolone use. Future antimicrobial stewardship efforts may benefit from promoting greater use of narrow-spectrum β-lactams in these patients. Full article

Background: Schools play a central role in child development and socialization and can function as protective environments that mitigate the effects of adversity. Building on the Social Ecological Model and Community School Transformation, we propose a “Schools-as-Neighborhoods” framework that conceptualizes schools as intentionally designed microenvironments capable of generating social capital, promoting positive childhood experiences, and buffering harmful neighborhood exposures through trauma-informed programming. Methods: We conducted a convergent mixed-methods study across four public and charter schools in Milwaukee, Wisconsin, serving grades five through nine. STRYV365’s peak team and Brain Agents gamified intervention were implemented between 2022–2024. Quantitative surveys and qualitative data assessed students’ lived experiences, exposure to adversity, emotional awareness, coping skills, and school connectedness/climate across multiple waves. Results: Across the four schools (n = 1626 students), baseline academic proficiency was low, and exposure to adversity was high among surveyed participants (n = 321), including bereavement (74%) and family incarceration (56%). Despite these challenges, qualitative findings revealed strengthened emotional regulation, empathy, motivation, and goal setting among students engaged in trauma-informed programming. Teachers reported improved peer interaction and community building during sustained implementation. Conclusion: The Schools-as-Neighborhoods framework highlights the value of trauma-informed, relationship-centered school environments in promoting student well-being. By positioning schools as cohesive ecosystems that foster belonging and cultivate social capital, this approach offers educators and policymakers a pathway for mitigating the effects of hostile lived environments and supporting students’ mental health, social development, and engagement in learning. Full article

Background/Objectives: Veterinarians often experience poor mental health, including higher than typical rates of depression and anxiety. Self-dehumanization, which refers to the feeling of being less than human, may reflect an important yet neglected factor in poor veterinarian mental health. Methods: 201 veterinarians completed an online survey consisting of demographic questions, questions regarding their practice settings, and measures of self-dehumanization, depression, anxiety, burnout, and secondary traumatic stress. Results: About 10% of veterinarians reported self-dehumanization. Most veterinarians had clinically significant symptoms of depression and anxiety, as well as moderate levels of burnout and secondary traumatic stress. Burnout and secondary traumatic stress positively predicted anxiety, while burnout, secondary traumatic stress, and self-dehumanization positively predicted depression. Cross-sectional mediation analyses indicated that burnout and secondary traumatic stress both significantly mediated the links between self-dehumanization and anxiety, and self-dehumanization and depression. Conclusions: This study provides new insight into the role of self-dehumanization in the poor mental health of veterinarians, which has implications for the development of preventative measures. Full article

Alcohol consumption is a globally prevalent lifestyle factor with complex and sometimes paradoxical effects on cardiovascular health, particularly regarding acute coronary syndrome (ACS). Earlier epidemiological studies described a J-shaped relationship between alcohol consumption and ACS risk; however, emerging evidence has increasingly challenged the validity of this concept. Mendelian randomization studies, genetic data, and recent pooled analyses suggest that the apparent cardioprotective effects of light-to-moderate drinking are largely attributable to residual confounding, including abstainer bias and socioeconomic factors, rather than true causal mechanisms. In contrast, excessive alcohol intake is linked to increased oxidative stress, inflammation, hypertension, and prothrombotic states, all of which contribute to plaque instability and the precipitation of ACS. Additionally, acute heavy drinking episodes may induce coronary vasospasm and arrhythmias, further elevating ACS risk. Genetic factors, drinking patterns, and beverage types may also modulate the relationship between alcohol and ACS, indicating the need for personalized risk assessment. Understanding these complex interactions is essential for clinicians when counseling patients on alcohol consumption within the context of cardiovascular prevention. This review aims to delve into current evidence on the epidemiology and pathophysiology linking alcohol consumption with ACS, providing a nuanced perspective that balances potential protective effects with the significant risks associated with excessive alcohol use, as well as summarizing all medical societies’ recommendations regarding alcohol consumption and cardiovascular health. Full article

Inappropriate use of antibiotics can stimulate antimicrobial resistance, since bacteria are capable of circumventing pharmacological action through various resistance mechanisms. Recently, during the COVID-19 pandemic, there has been an increase in the use of antimicrobials. This is an analytical, quantitative, and retrospective study on bacterial resistance and mortality in Intensive Care Unit (ICU) patients from 2017 to 2022. This study analyzed sociodemographic aspects, clinical, and laboratory parameters in patients admitted to the ICU. A total of 221 medical records of patients with multidrug-resistant bacteria in the ICU were included, with an outcome of 95 discharges (42.98%) and 126 deaths (53.01%). An increase in the prevalence of bacterial resistance in the ICU was identified during the Pandemic period, when compared to the Pre-Pandemic period. It was identified that the increase in bacterial resistance of some pathogens was associated with death. It was also observed that age was a factor for an increased risk of mortality in the ICU, no matter the sex of the patient. Importance of careful analysis in the use of antimicrobials, as well as in the care of ICU patients and in the surveillance of bacterial infections by health professionals. Full article

Background: Burnout among healthcare workers (HCWs) threatens workforce stability and patient care, particularly in rural hospitals where staff shortages, limited resources, and professional isolation amplify stress. Peer support interventions have demonstrated promise in urban centers, but their feasibility and impact in rural settings remain underexplored. Methods: We implemented and evaluated the Johns Hopkins RISE (Resilience in Stressful Events) peer support program across two rural hospital systems in the Mid-Atlantic United States. Using pre- and post-implementation surveys, we assessed anxiety (GAD-7), burnout (Maslach Burnout Inventory), resilience (CD-RISC), and perceptions of organizational culture of well-being. Linear and logistic regression models adjusted for age, site, and employment duration were used to evaluate outcomes over time. Results: A total of 868 respondents participated across three time points. Burnout and anxiety declined modestly post-implementation, while resilience improved initially but was not sustained at 2-year follow-up. Older employees demonstrated lower anxiety and burnout, while mid-career employees (3–10 years of employment) reported significantly higher distress. Importantly, access to peer support and perceived availability of supportive resources improved significantly over time, reflecting growing program integration. Conclusions: RISE was adapted successfully in rural hospital settings, with evidence of reduced burnout, lower anxiety, and increased perceived access to peer support. While resilience gains were not sustained, results suggest that a peer support program tailored to each organization can mitigate workforce distress in rural health systems. Addressing implementation and contextual barriers and sustaining organizational commitment are important for long-term impact. Expanding peer support to rural hospitals may improve workforce retention and care delivery in underserved communities. Full article

Although bioactive compounds are associated with various health-promoting effects, their practical application is limited by challenges such as low solubility, stability, and bioaccessibility. Proteins, carbohydrates, and hybrid colloidal systems are developed for various purposes, including the transport, protection, and controlled release of bioactives. These systems form the basis for the development of functional foods. The functionality of colloidal systems is driven by interactions between bioactive compounds and macromolecules. This review describes the characteristics of food colloid delivery systems; focuses on the mechanisms of colloid-bioactive compound interactions, particularly polyphenols and carotenoids; summarizes their impacts on functionality, bioaccessibility, and bioactivity; and provides insights into advanced characterization techniques. The mechanisms of interactions between food colloids and bioactive compounds are based on structural characteristics, which directly affect their functional and bioactive properties. Therefore, focusing on the latest technologies used to investigate these interactions, as well as understanding changes in component properties at both molecular and macroscopic levels, is crucial for designing more tunable and functional products in the near future. Full article

Prolonged operation of cotton picker poses significant risks of work-related musculoskeletal disorders (WMSDs), primarily driven by non-ergonomic cab layouts that fail to accommodate the unique “left-hand steering, right-hand lever” operational mode. Traditional optimization methods, relying on general digital human models or isolated surface electromyography (sEMG) measurements, often lack the physiological fidelity and computational efficiency for high-dimensional, personalized design. To address this interdisciplinary challenge in agricultural engineering and ergonomics, this study proposes a novel AMS-RF-DBO framework that integrates high-fidelity biomechanical simulation with intelligent optimization. A driver–cabin biomechanical model was developed using the AnyBody Modeling System (AMS) and validated against sEMG data (ICC = 0.695). This model generated a dataset linking cab layout parameters to maximum muscle activation (MA). Using steering wheel and control lever coordinates (X, Y, Z) as inputs, a Random Forest (RF) regression model demonstrated strong performance (R² = 0.91). Optimization with the Dung Beetle Optimizer (DBO) algorithm yielded an optimal configuration: steering wheel (L1 = 434 mm, H1 = 738 mm, θ = 32°) and control lever (L2 = 357 mm, H2 = 782 mm, M = 411 mm), reducing upper-limb MA from 3.82% to 1.47% and peak muscle load by 61.5%. This study not only provides empirical support for ergonomic cab design in cotton pickers to reduce operator fatigue and health risks but also establishes a replicable technical paradigm for ergonomic optimization of other specialized agricultural machinery. Full article

In urban design, public open spaces (POS) are essential for enhancing health and well-being across the lifetime. High-quality public open spaces facilitate the maintenance of optimal physical and mental health in older individuals by encouraging activities like physical exercise and social engagement. Preserving the physical and mental well-being of elderly individuals is a fundamental concern for aging policy. Nevertheless, urbanization presents considerable problems with the provision of public open spaces for activities aimed at the elderly. South Korea has more significant issues than other nations globally. This study, based on data from 477 valid questionnaires collected in and around Tapgol Park in Jung-gu, Seoul, employed a decision tree approach to identify key factors and paths that influence overall satisfaction. The goal was to identify decision paths that improve satisfaction while ensuring interpretability, thereby providing a scientific basis for urban space design and renovation. The results show that: (1) The decision tree of this study presents a hierarchical logic of quietness first, then accessibility and cleanliness, and finally price and vitality, which is consistent with the high frequency of use of Tapgol Park by the elderly and the diverse facilities in the surrounding area. (2) The key to improving the management and satisfaction of Tapgol Park in Seoul is the quietness of the site. (3) When the park is not quiet, users are most sensitive to bottom-line factors, such as commercial supply, evacuation safety, transportation accessibility, price perception, barrier-free, and anti-slips. (4) When the park is quiet, basic comfort factors such as smooth walking, all-day opening, sunlight, and no odor constitute the minimum condition set for entering the comfort zone. (5) Water experience, waterfront accessibility, proximity to cultural resources, and moderate business and community-oriented leisure facilities are key plus points. Methodologically, this study is among the first to apply a decision tree approach to low-income elderly using a small public open space in a historic city center, clarifying the nonlinear and hierarchical relationships among environmental factors within these low-income elderly groups. This provides empirical support and reference for the aging-friendly urban space in world heritage cities and other historical and cultural cities. Full article

Consumer food choices play a significant role in supporting sustainable, resilient, and equitable food systems by shaping the environmental, economic, and social impact of diets. To determine whether environmental concerns and innovativeness drive Europeans to buy more sustainable foods, quantitative data were collected from 3131 adults in three countries. A Logistic Regression Model was developed to assess the quantitative impact of variables on consumers’ likelihood to choose sustainably produced foods. Respondents who paid attention to whether food items are produced and/or packaged in an environmentally friendly way were 94% and 48% more likely to purchase sustainably produced products, respectively. Readiness to purchase a dairy product that the buyer had never heard of resulted in a 15% increase in the likelihood of selecting sustainably produced foods. Additionally, respondents living in Germany were 30% more likely to choose sustainable products compared to Polish consumers, while Czech consumers were 10% less likely to do so. Implementing campaigns focusing on promoting sustainable diets could consequently determine and accelerate the adoption of environmentally friendly production practices in the food system. Our findings provide evidence for policymakers, the business community, and educators who aspire to improve the health of people and the planet as a whole. Full article

(1) Background: The Sustainable Development Goals highlight the importance of ensuring healthy lives and promoting well-being for all. Within this framework, it is essential to improve health outcomes for people with disabilities and to continue generating scientific evidence in this field. This study aimed to (I) analyze differences in anthropometric characteristics and cardiorespiratory fitness among adults with disabilities, and (II) analyze the association between anthropometric characteristics and cardiorespiratory fitness in the total sample and by sex. (2) Methods: Fifty-three adults over 50 years of age with disabilities participated in this study. Anthropometric measurements and the 6 min walk test (6MWT) were conducted, recording physical-physiological and mechanical variables (using heart rate monitors and Stryd devices). (3) Results: Significant differences were observed between men and women with disabilities in height (p < 0.001, ES = −1.10), hip-to-chest ratio (p < 0.05, ES = 0.75), mean heart rate (p < 0.05, ES = 0.67), and absolute minimum power (p < 0.05, ES = 0.64) achieved during the 6MWT. A significant correlation was found between anthropometric characteristics and 6MWT performance across the entire sample (r = −0.29 to −0.67, p < 0.05). Among women, these characteristics were associated with distance covered (r = −0.35 to −0.42, p < 0.05), whereas in men, they were associated with relative power (r = −0.60 to −0.83, p < 0.05). (4) Conclusions: The findings suggest that, in this sample, anthropometric characteristics are associated with specific 6MWT performance variables, with patterns differing by sex. Full article

Background: Telemedicine can improve early symptom detection using medical devices and applications. It can also help identify barriers to patient adherence and enhance communication with healthcare professionals. This study aimed to evaluate the applicability, usability, and patient satisfaction with telemonitoring devices and apps for individuals with heart failure and type 2 diabetes. Methods: In a randomized study, patients in the Intervention Group received six months of nursing teleassistance and telemonitoring using a wearable electrocardiograph, a step tracker, and an App for recording clinical information and conducting video calls. Usability was measured using the System Usability Scale (SUS) and satisfaction with a six-item questionnaire. Results: A total of 43 patients (71 ± 8 years) were enrolled in the intervention group. A total of 41 (95%) of patients utilized the App daily, entering 13,048 information, 53 ± 59 per patient. The nurses performed 896 video-calls, 22 ± 21 per patient. The mean number of walking sessions recorded was 6.1 ± 0.9 per week (159 ± 24 per patient). Thirty-five patients (81%) used a 3-lead ECG and recorded 942 traces, 27 ± 14 per patient. At the end, 40 SUS were collected from patients: 15 (38%, 71 ± 7 years) considered the system excellent or good, 20 (50%, 71 ± 8 years) thought it fair, and 5 (13%, 74 ± 7 years) considered the system offered poor. The overall assessment of patient satisfaction with the service was 22 ± 3.3. Conclusions: This study provides evidence that, although technology can be complex for older adults, it is broadly accepted by most patients, especially when the benefits are understood. The support offered by nurses is essential for significantly enhancing the overall patient experience. Full article

Background/Objectives: Multidrug-resistant tuberculosis remains a critical public health challenge in Kazakhstan, yet the genomic determinants contributing to its emergence are still insufficiently understood. Although the quantity of genomic studies from Central Asia and the wider post-Soviet region has increased in recent years, the involvement of DNA repair and genome maintenance pathways in the development of resistance within Kazakhstan has not been comprehensively explored. Methods: In this study, we performed whole-genome analysis of 175 Mycobacterium tuberculosis clinical isolates collected across Kazakhstan between 2010 and 2022 to evaluate the contribution of single-nucleotide polymorphisms in DNA replication, repair, and recombination (3R) genes to the evolution of drug resistance. Results: Alongside well-established resistance mutations in gyrA, we identified recurrent variants in 3R-associated loci (genes involved in DNA replication, repair, and recombination)—including polA, uvrC and ligC—that were enriched among drug-resistant isolates, suggesting a broader role for genome maintenance pathways in facilitating resistance evolution under treatment pressure. Conclusions: These findings provide the first region-specific genomic insights into 3R gene variation in Kazakhstani M. tuberculosis isolates. Full article

This study investigated the effects and mechanisms of broccoli extract containing more than 99.0% β-NMN (BRC) on UVB-induced skin damage, including moisture loss, oxidative stress, inflammation, wrinkle formation, and melanin production, using in vitro and in vivo models. BRC treatment significantly alleviated UVB-induced skin dehydration, oxidative stress, and inflammatory responses, as well as inhibited wrinkle formation and melanin synthesis. Mechanistically, BRC enhanced skin hydration and barrier function by upregulating hyaluronic acid synthases and genes related to sphingolipid metabolism, while simultaneously suppressing NF-κB signaling and COX-2 expression, thereby re-ducing inflammation. Moreover, BRC promoted collagen synthesis by activating the TGF-βR1/Smad3/Collagen pathway and prevented extracellular matrix degradation by inhibiting JNK/c-Fos/c-Jun/MMPs signaling. In addition, BRC modulated the cAMP/PKA/CREB/MITF/TRPs pathway, leading to reduced melanin production. These findings suggest that BRC supplementation may effectively protect against UVB-induced skin damage, supporting its potential application as a functional ingredient for skin health. Full article

Background: The (COVID-19) pandemic profoundly disrupted daily routines and physical activity (PA), especially among university students, due to restrictions and limited access to sports facilities. As this group is particularly vulnerable to sedentary lifestyles and mental health issues, understanding their PA patterns is crucial. This study explores overall and domain-specific PA levels and the influence of sociodemographic factors, offering insights for promoting sustainable PA strategies in higher education during and beyond health crises. Methods: A cross-sectional online survey was conducted among University of Foggia students during the pandemic. The participants completed the validated Italian IPAQ-Long to assess PA across various domains. Associations with demographics and perceived barriers were analyzed via t tests, ANOVA, and nonparametric tests. Results: A total of 301 students completed the survey. Despite barriers such as limited living space, low income, and sports facility closures, 66% of the participants reported high PA levels, mainly through work-related and leisure activities. This remains insufficient. PA varied significantly by gender, income, residence, and employment status: males reported higher leisure PA, whereas females engaged more in active transport and domestic activities. Rural residents and those with moderate incomes demonstrated higher overall PA, whereas employed students presented lower activity levels. These findings underscore the complex socioeconomic and environmental factors shaping PA behavior during an unprecedented global health crisis. Conclusions: The findings reveal that students’ resilience in maintaining PA is a coping mechanism despite socioeconomic and environmental barriers. Tailored, accessible PA initiatives integrated into university curricula can enhance student well-being, academic performance, and long-term health during and after public health emergencies. Universities should adopt accessible, equity-oriented PA initiatives to promote physical and mental health and enhance public-health preparedness during future emergencies. Full article

Aspergillus flavus colonizes oil-seed crops, contaminating them with aflatoxins; highly carcinogenic mycotoxins that cause severe health and economic losses. Genetic studies may reveal new targets for effective control strategies. Here, we characterized a putative WOPR transcription factor gene, osaA, in A. flavus. Our results revealed that osaA regulates conidiation and sclerotial formation. Importantly, deletion of osaA reduces aflatoxin B₁ production, while, unexpectedly, transcriptome analysis indicated upregulation of aflatoxin biosynthetic genes, suggesting post-transcriptional or cofactor-mediated regulation. Cyclopiazonic acid production also decreased in the absence of osaA. In addition, the osaA mutant exhibited upregulation of genes in the imizoquin and aspirochlorine clusters. Moreover, osaA is indispensable for normal seed colonization; deletion of osaA significantly reduced fungal burden in corn kernels. Aflatoxin content in seeds also decreased in the absence of osaA. Furthermore, deletion of osaA caused a reduction in cell-wall chitin content, as well as alterations in oxidative stress sensitivity, which could in part contribute to the observed reduction in pathogenicity. Additionally, promoter analysis of osaA-dependent genes indicated potential interactions with stress-responsive regulators, indicated by an enrichment in Sko1 and Cst6 binding motifs. Understanding the osaA regulatory scope provides insight into fungal biology and identifies potential targets for controlling aflatoxin contamination and pathogenicity. Full article

The current study assessed organizational and psychosocial factors related to intentions to quit in American working college undergraduates (N = 382; mean age = 19 years; ~80% female). Students were surveyed on organizational scales (e.g., organizational identification, perceived support, work–life conflict, and intentions to quit) and psychosocial scales (e.g., perceived stress, social support, burnout, and mental health conditions). Variables significantly correlated with intent to quit at the bivariate level were included in an exploratory multiple regression model. The results indicated that burnout, engagement, organizational identification, perceived social support, and life–work conflict were uniquely predictive of intention to quit. A subsequent path analysis based on the Job Demands–Resources model revealed a good fit to the student data: demands (i.e., work–life conflict, perceived stress) and resources (organizational support and identification) predicted burnout and engagement, which in turn predicted intent to quit (along with a direct path from organizational support). This model can therefore explain behavior in both traditional and college undergraduate employees. In order to retain these employees, organizations should invest in practices that increase organizational identification and perceived support, as well as initiatives that help students mitigate the increased risks of stress and burnout associated with working while in college. Full article

Motorcycle emissions are a growing environmental and public health concern in many low- and middle-income countries. While several studies have examined the emission profiles from larger vehicles in urban areas, very few have analyzed motorcycle emissions through a parametric and non-parametric multivariate lens, combining technical, behavioral, and socioeconomic factors, a gap that this study attempts to address. MANOVA and Kruskal–Wallis H test analyses highlighted visible smoke emissions (hydrocarbon: H = 30.62, p < 0.001; carbon monoxide: H = 16.71, p < 0.001; dioxygen: H = 6.67, p = 0.010), year of manufacturing (carbon monoxide: H = 20.61, p < 0.001; hydrocarbon: H = 11.80, p = 0.008), average fuel consumption (carbon dioxide: H = 13.32, p = 0.004), and daily driving distance (carbon monoxide: H = 10.09, p = 0.018) as significant predictors of emissions. The results also indicate that newer and well-maintained motorcycles (2018–2021) consistently showed the lowest carbon monoxide and HC levels compared to the older and poorly maintained counterparts with the highest emissions. Consistently, motorcycles with visible smoke showed substantially elevated carbon monoxide and hydrocarbons and reduced dioxygen, establishing visible smoke as a practical marker for excessive emissions. Additionally, younger riders (19–28 years) exhibited higher hydrocarbon emissions, while greater riding experience and more passengers influenced dioxygen levels. Spearman correlation analysis reinforced these patterns, with visible smoke showing strong positive correlations with carbon monoxide (ρ = 0.21) and hydrocarbon (ρ = 0.28), and carbon monoxide was negatively associated with motorcycle age (ρ = −0.18). These findings underscore manufacturing year, vehicle maintenance, and visible smoke as practical, high-impact targets for reducing motorcycle emissions, offering a basis for targeted emission control strategies. Full article

Background: Eating habits such as fruit and vegetable (FV) consumption and breakfast frequency are well recognized for their contribution to overall health and well-being. However, the psychological mechanisms that explain the link between these habits and life satisfaction remain poorly explored among university students in the health sciences. Objective: To examine whether positive affect mediates the relationship between FV consumption, breakfast frequency, and life satisfaction among health sciences students. Methods: A cross-sectional study was conducted with 511 students. FV consumption, breakfast frequency, positive affect, and life satisfaction were assessed using self-report measures. Mediation models were applied to estimate direct and indirect associations. Results: FV consumption and breakfast frequency were positively associated with both positive affect and life satisfaction. Although the direct associations with life satisfaction were not significant, the indirect associations through positive affect were significant (FV: β = 0.114, 95% CI [0.055, 0.173]; breakfast: β = 0.133, 95% CI [0.073, 0.192]). The model accounted for 51.4% of the variance in life satisfaction. Conclusions: The results highlight the role of positive affect as a psychological mechanism linking everyday eating habits to life satisfaction, emphasizing the need to integrate emotional components into strategies for promoting healthy lifestyles among university populations. Full article

The health and operational continuity of emergency responders are fundamental pillars of sustainable and resilient disaster management systems. These personnel operate in high-risk environments, exposed to intense physical, environmental, and psychological stress. This makes it crucial to monitor their health to safeguard their well-being and performance. Traditional methods, which rely on intermittent, voice-based check-ins, are reactive and create a dangerous information gap regarding a responder’s real-time health and safety. To address this sustainability challenge, the convergence of the Internet of Things (IoT) and wearable biosensors presents a transformative opportunity to shift from reactive to proactive safety monitoring, enabling the continuous capture of high-resolution physiological and environmental data. However, realizing a field-deployable system is a complex “system-of-systems” challenge. This review contributes to the field of sustainable emergency management by analyzing the complete technological chain required to build such a solution, structured along the data workflow from acquisition to action. It examines: (1) foundational health sensing technologies for bioelectrical, biophysical, and biochemical signals; (2) powering strategies, including low-power design and self-powering systems via energy harvesting; (3) ad hoc communication networks (terrestrial, aerial, and space-based) essential for infrastructure-denied disaster zones; (4) data processing architectures, comparing edge, fog, and cloud computing for real-time analytics; and (5) visualization tools, such as augmented reality (AR) and heads-up displays (HUDs), for decision support. The review synthesizes these components by discussing their integrated application in scenarios like firefighting and urban search and rescue. It concludes that a robust system depends not on a single component but on the seamless integration of this entire technological chain, and highlights future research directions crucial for quantifying and maximizing its impact on sustainable development goals (SDGs 3, 9, and 11) related to health, sustainable cities, and resilient infrastructure. Full article

Background/Objectives: Gestational exposure to a high-fat diet (HFD) reprograms hypothalamic orexigenic circuits prenatally. However, whether astrocytes, critical modulators of this system, are also imprinted by HFD in the fetal brain remains unknown. We investigated the impact of HFD on the prenatal neuroglial architecture of the lateral hypothalamic area (LHA). Methods: Female Wistar rats were fed a control or a 60% fat diet for 12 weeks. Upon reaching obesity (Lee index ≥ 310), dams were mated. Fetuses were harvested via cesarean section at term, and their brains were processed for immunohistochemistry and morphometry to assess cell proliferation, orexin neuron density, and astrocytic reactivity in the LHA. Results: HFD significantly increased cell proliferation and orexinergic neuron density, and induced early signs of astrocyte reactivity in the fetal LHA. These findings reveal that both neuronal and glial components of the LHA orexigenic axis are structurally reprogrammed before birth. Conclusions: This study provides the first evidence that HFD simultaneously alters neuronal and glial developmental trajectories in the fetal hypothalamus. The concurrent programming of astrocytes and orexigenic neurons suggests a prenatal origin for neuroinflammatory susceptibility, reframing obesity as a neurodevelopmental disorder shaped by early life nutritional environments. Full article

VD (VD), a hormone-like, fat-soluble molecule, is essential for several biological processes, such as gene regulation, calcium balance, bone health, immune function, antiviral defense, and neuromuscular activity. Its deficiency is associated with various disorders, including chronic hypocalcemia and increased risk of severe diseases, such as COVID-19. Monitoring 25-hydroxyVD (25-OH-D) levels is vital, with serum 25-OH-VD being the standard marker. While chromatography and immunometric assays are well-established, innovative point-of-care (POC) platforms like AFIAS-1^® (Boditech & Menarini, Gangwon, Republic of Korea) are emerging as rapid and automated alternatives, particularly advantageous for decentralized settings such as pharmacies, general practitioners’ offices, and specialized hospital centers like intensive care units. This study compared AFIAS-1^® using whole blood with the gold standard UHPLC-MS/MS using plasma in 50 samples, showing a strong correlation and confirming AFIAS-1^® as a reliable method for measuring 25-OH-D levels. Full article

This study aimed to evaluate the health-promoting potential of wafers enriched with almond peel as a natural source of bioactive compounds. Wafers were prepared with different concentrations of almond peel (1%, 2%, 5%, and 10%) and analyzed to determine their phenolic content, antioxidant capacity, enzyme inhibition, anticancer properties, and sensory properties. Three types of samples were examined: buffer extracts (PBS), ethanol extracts (EtOH), and samples obtained after in vitro digestion (TRW). Antioxidant properties were assessed using ABTS^+• and DPPH^• assays, as well as Fe²⁺ chelation and reducing power tests. Enzyme inhibitory activities against LOX, COX, ACE, and lipase, and antiproliferative potential of hydrolysates toward AGS and HT-29 cell lines were also determined. The highest levels of total phenolic, flavonoids, and phenolic acids were found in digested samples of wafers with 10% almond peel addition (W10), reaching 2.243 mg/g, 6.153 µg/g, and 0.554 mg/g, respectively, while PBS extracts of control wafers (WK) showed the lowest values (0.159 mg/g, 0.146 µg/g, and 0.316 mg/g, respectively). The digested W10 samples showed the strongest antioxidant and enzyme inhibitory activities. The wafer hydrolysates caused only a modest reduction in HT-29 cell viability, and this effect was observed exclusively at the higher concentrations tested. The results confirm that almond peel enhances the health-promoting properties of wafers. Full article