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Acute Coronary Syndromes: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 891

Special Issue Editors


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Guest Editor
Department of Cardiology, Nicosia General Hospital, State Health Services Organization, Nicosia 2029, Cyprus
Interests: interventional cardiology; percutaneous coronary intervention (PCI); acute myocardial infarction; acute coronary syndromes; transcatheter interventions; structural interventions; cardiovascular diseases; advanced coronary imaging techniques
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Cardiology, Nicosia General Hospital, State Health Services Organization, Nicosia 2029, Cyprus
Interests: interventional cardiology; percutaneous coronary intervention (PCI); acute myocardial infarction; acute coronary syndromes; transcatheter interventions; structural interventions; cardiovascular diseases; advanced coronary imaging techniques

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the Special Issue “Acute Coronary Syndrome: From Diagnosis to Treatment” in the Journal of Clinical Medicine. Acute Coronary Syndrome (ACS) remains one of the leading causes of morbidity and mortality worldwide, presenting ongoing challenges in early diagnosis, effective treatment, and long-term management. Recent advancements in biomarker research, imaging modalities, and interventional techniques have significantly transformed ACS management, yet many gaps remain.

This Special Issue aims to collect high-impact research and comprehensive reviews that address these gaps, providing insights into innovative diagnostic strategies, novel therapeutic approaches, and multidisciplinary management frameworks. We seek to foster collaboration and share advancements that can shape clinical practices and improve patient outcomes.

Scope and Themes:

  • Advanced risk stratification and the role of biomarkers in early diagnosis;
  • Innovations in imaging technologies for ACS detection and intervention;
  • Efficacy and safety of emerging pharmacological and interventional treatments;
  • Management of ACS in special populations (e.g., the elderly and patients with comorbidities);
  • Strategies for optimizing long-term care and patient adherence;
  • Health system interventions and quality improvement in ACS care.

We welcome original research articles, clinical trials, and expert reviews. We look forward to receiving your valuable contributions.

Dr. Andreas Mitsis
Dr. Christos Eftychiou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndrome
  • diagnosis
  • biomarkers
  • interventional cardiology
  • imaging
  • pharmacotherapy
  • patient management
  • health systems
  • special populations
  • clinical trials

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Published Papers (1 paper)

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Review

18 pages, 587 KiB  
Review
The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights
by Andreas Mitsis, Stefanos Sokratous, Georgia Karmioti, Michaela Kyriakou, Michail Drakomathioulakis, Michael M. Myrianthefs, Christos Eftychiou, Nikolaos P. E. Kadoglou, Stergios Tzikas, Nikolaos Fragakis and George Kassimis
J. Clin. Med. 2025, 14(13), 4795; https://doi.org/10.3390/jcm14134795 - 7 Jul 2025
Viewed by 662
Abstract
C-reactive protein (CRP) has emerged as a valuable biomarker in acute myocardial infarction (AMI), offering multiple insights into diagnosis, prognosis, and therapeutic strategies. In the diagnostic domain, elevated CRP levels serve as an early indicator of AMI, aiding in prompt identification and initiation [...] Read more.
C-reactive protein (CRP) has emerged as a valuable biomarker in acute myocardial infarction (AMI), offering multiple insights into diagnosis, prognosis, and therapeutic strategies. In the diagnostic domain, elevated CRP levels serve as an early indicator of AMI, aiding in prompt identification and initiation of treatment. Prognostically, CRP is a strong predictor of adverse outcomes post-AMI, correlating with increased mortality and cardiovascular events. Beyond its diagnostic and prognostic roles, CRP also exposes therapeutic avenues in AMI management. Targeting CRP through pharmacological interventions has shown promise in reducing inflammatory responses, thereby mitigating myocardial damage and improving clinical outcomes. However, CRP’s low specificity, influenced by elevation in non-cardiac conditions, remains a clinical limitation that warrants consideration. This review comprehensively examines the evolving role of CRP in AMI, exploring its diagnostic accuracy, prognostic significance, and potential as a therapeutic target. The understanding of the complex role of CRP in AMI provides clinicians with valuable tools for risk stratification, treatment optimization, and personalized patient care in the acute setting. Full article
(This article belongs to the Special Issue Acute Coronary Syndromes: From Diagnosis to Treatment)
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