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Most Cited

  • Review
  • Open Access
305 Citations
27,889 Views
25 Pages

Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

  • Uzma Salam,
  • Shakir Ullah,
  • Zhong-Hua Tang,
  • Ahmed A. Elateeq,
  • Yaseen Khan,
  • Jafar Khan,
  • Asif Khan and
  • Sajid Ali

6 March 2023

Several environmental stresses, including biotic and abiotic factors, adversely affect the growth and development of crops, thereby lowering their yield. However, abiotic factors, e.g., drought, salinity, cold, heat, ultraviolet radiations (UVr), rea...

  • Review
  • Open Access
184 Citations
66,934 Views
27 Pages

29 June 2023

Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used ne...

  • Review
  • Open Access
179 Citations
30,770 Views
37 Pages

7 February 2024

Drug development is expensive, time-consuming, and has a high failure rate. In recent years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery, offering innovative solutions to complex challenges in the pharmaceutica...

  • Review
  • Open Access
178 Citations
39,407 Views
46 Pages

Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

  • Sonia Facchin,
  • Luisa Bertin,
  • Erica Bonazzi,
  • Greta Lorenzon,
  • Caterina De Barba,
  • Brigida Barberio,
  • Fabiana Zingone,
  • Daria Maniero,
  • Marco Scarpa and
  • Edoardo Vincenzo Savarino
  • + 2 authors

26 April 2024

The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such as dietary fibers. Through the fermentation of these food components...

  • Review
  • Open Access
166 Citations
26,851 Views
32 Pages

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

  • Lakshmi Kumari,
  • Yash Choudhari,
  • Preeti Patel,
  • Ghanshyam Das Gupta,
  • Dilpreet Singh,
  • Jessica M. Rosenholm,
  • Kuldeep Kumar Bansal and
  • Balak Das Kurmi

27 April 2023

A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70...

  • Article
  • Open Access
160 Citations
10,148 Views
16 Pages

Multiple Brain Tumor Classification with Dense CNN Architecture Using Brain MRI Images

  • Osman Özkaraca,
  • Okan İhsan Bağrıaçık,
  • Hüseyin Gürüler,
  • Faheem Khan,
  • Jamil Hussain,
  • Jawad Khan and
  • Umm e Laila

28 January 2023

Brain MR images are the most suitable method for detecting chronic nerve diseases such as brain tumors, strokes, dementia, and multiple sclerosis. They are also used as the most sensitive method in evaluating diseases of the pituitary gland, brain ve...

  • Review
  • Open Access
137 Citations
13,875 Views
44 Pages

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

  • Peter Takáč,
  • Radka Michalková,
  • Martina Čižmáriková,
  • Zdenka Bedlovičová,
  • Ľudmila Balážová and
  • Gabriela Takáčová

7 February 2023

Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recen...

  • Review
  • Open Access
121 Citations
10,664 Views
18 Pages

15 February 2023

Diabetic Nephropathy (DN) is a serious complication of type I and II diabetes. It develops from the initial microproteinuria to end-stage renal failure. The main initiator for DN is chronic hyperglycemia. Hyperglycemia (HG) can stimulate the resident...

  • Review
  • Open Access
109 Citations
39,292 Views
16 Pages

Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines

  • Andreas G. Tsantes,
  • Stavroula Parastatidou,
  • Emmanuel A. Tsantes,
  • Elli Bonova,
  • Konstantina A. Tsante,
  • Petros G. Mantzios,
  • Aristeidis G. Vaiopoulos,
  • Stavros Tsalas,
  • Aikaterini Konstantinidi and
  • Rozeta Sokou
  • + 4 authors

28 January 2023

Significant cross talk occurs between inflammation and coagulation. Thus, coagulopathy is common in sepsis, potentially aggravating the prognosis. Initially, septic patients tend to exhibit a prothrombotic state through extrinsic pathway activation,...

  • Article
  • Open Access
98 Citations
14,306 Views
15 Pages

Occurrence of Microplastics in Most Consumed Fruits and Vegetables from Turkey and Public Risk Assessment for Consumers

  • Rana Berfin Aydın,
  • Aykut Yozukmaz,
  • İdris Şener,
  • Funda Temiz and
  • Daniela Giannetto

4 August 2023

Microplastics are transferred to humans through the food chain by consuming food contaminated with microplastics. However, the knowledge about the risks of dietary exposure for humans to these particles is very limited. Moreover, only a few studies o...

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Life - ISSN 2075-1729