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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Papers in Medical Research: 3rd Edition

edited by

Christian Lehmann

submission deadline 31 Aug 2025 | 14 articles | Viewed by 22864

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Recent Advances in Crop Genetics and Breeding

edited by

Tianxiao Chen

Xiangjin Wei

Baohua Feng

and Long Chen

submission deadline 31 Aug 2025 | 5 articles | Viewed by 5767

Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection

(This special issue belongs to the Section Plant Science)

Migraine and Headache: From Pathophysiological Aspects

edited by

Jacob Genizi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2475

Keywords: migraine; headache; pathophysiology; treatment; medication

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Pediatric Rheumatic and Autoimmune Diseases

edited by

Lampros Fotis

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1328

Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis

(This special issue belongs to the Section Medical Research)

Innovative Drug Development: Balancing Efficacy and Toxicity in Novel Pharmaceuticals

edited by

Iasmina Marcovici

submission deadline 31 Aug 2025 | 1 articles | Viewed by 932

Keywords: drug development; pharmaceuticals; bioactive compounds; new drug candidates; drug delivery systems; pharmaceutical formulations; efficacy and toxicity screening

(This special issue belongs to the Section Pharmaceutical Science)

Recent Advances in Plant Genomics and Genetics

edited by

Tianxiao Chen

Baohua Feng

, Long Chen and

Xiangjin Wei

submission deadline 31 Aug 2025 | 1 articles | Viewed by 831

Keywords: high-throughput genotyping; plant genetics; plant genomics; genetic markers; genetic improvements; genome editong; CRISPR/Cas9; genomic selection

(This special issue belongs to the Section Genetics and Genomics)

Recent Advances in Bone Biology

edited by Barbara Peruzzi,

Martina Leopizzi

and Giulia Battafarano

submission deadline 31 Aug 2025 | Viewed by 276

Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism

(This special issue belongs to the Section Physiology and Pathology)

Integrating Health Informatics and Artificial Intelligence for Advanced Medicine

edited by

Joaquim Carreras

submission deadline 31 Aug 2025 | Viewed by 276

Keywords: artificial intelligence; machine learning; artificial neural networks; prognosis; treatment; medicine; health care; pathology

(This special issue belongs to the Section Medical Research)

New Insights into Cellular Inflammation and Regeneration

edited by

Jea-Hyun Baek

submission deadline 31 Aug 2025 | Viewed by 263

Keywords: cellular inflammation; tissue regeneration; immune modulation; regenerative medicine; inflammatory pathways; immune cells and tissue repair; chronic inflammation; biomarkers of regeneration; immune-tissue crosstalk; wound healing; fibrosis and regeneration; inflammation resolution; tissue remodeling; regenerative microenvironment; inflammation-driven pathogenesis; translational immunology

(This special issue belongs to the Section Physiology and Pathology)

Cutting-Edge Techniques and Innovations in the Management of Aortic Aneurysm

edited by Dimitrios Iliopoulos

submission deadline 31 Aug 2025 | Viewed by 198

Keywords: aneurysm; aorta; aortic root; biomechanics; aortic dissection; thoracoabdominal aneurysm; valve-sparing aortic root replacement; perfusion

(This special issue belongs to the Section Medical Research)

Gene Regulation and Expression in Tumors

edited by

Beniamin Grabarek

and Dawid Sobański

submission deadline 31 Aug 2025 | Viewed by 191

Keywords: gene regulation; tumor biology; transcriptional dysregulation and epigenetics; cancer biomarkers; therapeutic targets; multi-omics approaches

(This special issue belongs to the Section Physiology and Pathology)

Migraine and Headache: From Clinical and Therapeutic Aspects

edited by

Jacob Genizi

submission deadline 31 Aug 2025 | Viewed by 188

Keywords: migraine; headache; treatment; medication

(This special issue belongs to the Section Medical Research)

The Drug Development for Neurodegenerative Diseases

edited by David R. Elmaleh

submission deadline 31 Aug 2025 | Viewed by 144

Keywords: neurodegenerative disease; drug treatment approaches; quality of life improvement

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Trends in Tumor Pathology and Precision Oncology

edited by

Valerio Gaetano Vellone

and Gabriele Gaggero

submission deadline 15 Sep 2025 | 2 articles | Viewed by 5588 | Submission Open

Keywords: gynecologic pathology; pediatric pathology; neuropathology; molecular diagnostics; precision oncology

(This special issue belongs to the Section Physiology and Pathology)

Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents

edited by

Katarzyna Oszajca

and

Janusz Szemraj

submission deadline 15 Sep 2025 | 3 articles | Viewed by 2632 | Submission Open

Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis

(This special issue belongs to the Section Microbiology)

New Insights Into Leishmaniasis and Chagas Disease: Focus on Diagnosis and Genetic Characterization of Parasites: 2nd Edition

edited by

Alba Abras

and Cristina Ballart

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2387 | Submission Open

Keywords: leishmania; leishmaniasis; chagas disease; American trypanosomiasis; Trypanosoma cruzi; diagnostics; genetic diversity; characterization; neglected tropical disease

(This special issue belongs to the Section Epidemiology)

Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases

edited by

John Ong

submission deadline 16 Sep 2025 | 1 articles | Viewed by 1483 | Submission Open

Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease

(This special issue belongs to the Section Medical Research)

Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Lorena Perrone

and Oualid Sbai

submission deadline 25 Sep 2025 | Viewed by 301 | Submission Open

Keywords: mitochondria; neurodegeneration; oxidative stress; calcium homeostasis; mitochondrial fission/fusion; inflammation; gut– brain axis; mitophagy; NLRP3 inflammasome

(This special issue belongs to the Section Physiology and Pathology)

Carbon and Nitrogen Cycles in Terrestrial Ecosystems

edited by

Naiqing Pan

submission deadline 26 Sep 2025 | 3 articles | Viewed by 4840 | Submission Open

Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles

(This special issue belongs to the Section Diversity and Ecology)

Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition

edited by

Roberto Cannataro

submission deadline 26 Sep 2025 | 1 articles | Viewed by 2377 | Submission Open

Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease

edited by

Marcin Kosmalski

and Monika Różycka-Kosmalska

submission deadline 29 Sep 2025 | 5 articles | Viewed by 8300 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension

(This special issue belongs to the Section Medical Research)

Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health

edited by

Thomas Tsiampalis

and Matina Kouvari

submission deadline 29 Sep 2025 | 1 articles | Viewed by 4951 | Submission Open

Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors

(This special issue belongs to the Section Epidemiology)

Advances in Knee Biomechanics

edited by Jason Shearn

submission deadline 30 Sep 2025 | 9 articles | Viewed by 29775 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

Advanced Strategies in Fracture Treatments

edited by

Kai-Cheng Lin

and Chun-Yu Chen

submission deadline 30 Sep 2025 | 9 articles | Viewed by 19124 | Submission Open

Keywords: state of the art; peri-articular fracture; osteoporotic fracture; fragility fracture; treatment protocols

(This special issue belongs to the Section Medical Research)

Ion Channels and Neurological Disease: 2nd Edition

edited by

Carlo Musio

and Marzia Martina

submission deadline 30 Sep 2025 | 7 articles | Viewed by 14937 | Submission Open

Keywords: ion channels; neurological diseases; neurodegeneration; pain; cellular and animal models; neuronal excitability; neuronal activity; synaptic transmission; structural and functional correlates; computational modeling; pathophysiology and pathogenesis; channelopathies; altered currents; neuropharmacology and ethnopharmacology; drug screening; delivery; and targeting; pharmacological treatments; molecular therapeutic options; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition

edited by

Jianfeng Xu

submission deadline 30 Sep 2025 | 6 articles | Viewed by 14400 | Submission Open

Keywords: plant cell culture; plant tissue culture; medicinal plants; secondary metabolites; bioactive compounds; nutraceuticals; recombinant proteins; biologics

(This special issue belongs to the Section Plant Science)

Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition

edited by

Mariana Floria

Anca Trifan

and

Daniela Maria Tanase

submission deadline 30 Sep 2025 | 13 articles | Viewed by 13587 | Submission Open

Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steato-hepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases

(This special issue belongs to the Section Physiology and Pathology)

Etiology, Prediction and Prognosis of Ischemic Stroke

edited by

Vida Abedi

Ramin Zand

and Jiang Li

submission deadline 30 Sep 2025 | 3 articles | Viewed by 7190 | Submission Open

Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies

(This special issue belongs to the Section Physiology and Pathology)

A Paradigm Shift in Airway and Pain Management—2nd Edition

edited by

Jui An Lin

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7133 | Submission Open

Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Medical Research)

Veterinary Pathology and Veterinary Anatomy: 3rd Edition

edited by

Gheorghe Solcan

and

Carmen Solcan

submission deadline 30 Sep 2025 | 5 articles | Viewed by 5582 | Submission Open

Keywords: veterinary pathology; veterinary anatomy; SARS-CoV-2 pandemic; climate change; environmental pollution; diagnosis and treatment of animal diseases; computer modelling of pathological processes

(This special issue belongs to the Section Animal Science)

Advancements in Postoperative Management of Patients After Surgery

edited by

Antonino Zanghi

Luigi La Via

Antonino Maniaci

and Alessandro Cappellani

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5259 | Submission Open

Keywords: surgery; ERAS; postoperative management; recovery; pain

(This special issue belongs to the Section Medical Research)

Multi-Omics for Diagnosing Diseases: Bioinformatics Approaches and Integrative Data Analyses

edited by

Emanuel Maldonado

and

Imran Khan

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2417 | Submission Open

Keywords: bioinformatics; computer hardware; software; and methods; first-/second-/third-generation sequencing; clinical genomics; mendelian diseases; whole-exome sequencing; evolutionary and comparative genomics; whole-genome sequencing; multi-omics; microbiome diseases

(This special issue belongs to the Section Genetics and Genomics)

Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)

edited by

Yongseek Park

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2395 | Submission Open

Keywords: chronic kidney disease; vascular dysfunction; endothelial cells

(This special issue belongs to the Section Medical Research)

Enhancements in Screening Pathways for Early Detection of Lung Cancer

edited by

Paolo Albino Ferrari

and

Antonio Maccio

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2245 | Submission Open

Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence

(This special issue belongs to the Section Medical Research)

Advances in Intensive Care Medicine

edited by

Denise Battaglini

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2191 | Submission Open

Keywords: machine learning; critical care; intensive care; ARDS; mechanical ventilation; personalized medicine; advances

(This special issue belongs to the Section Medical Research)

Natural Substances in Nutrition and Health of Animals: 2nd Edition

edited by

Karaffová Viera

Zuzana Ševčíková

and

Viera Almášiová

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1815 | Submission Open

Keywords: natural products; organic acids; probiotics; prebiotics; and synbiotics; plant extracts; animal nutrition; animal physiology; animal embryology; animal reproduction; animal models

(This special issue belongs to the Section Animal Science)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1659 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Athlete Physiology

edited by

Maamer Slimani

and

Nicola Luigi Bragazzi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1235 | Submission Open

Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship

(This special issue belongs to the Section Physiology and Pathology)

Acari: Biodiversity, Biogeography and Taxonomy Studies

edited by Pavel B. Klimov

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1160 | Submission Open

Keywords: phylogenetics; systematics; evolution and co-evolution; biodiversity; ecology; host associations; role of mites in agriculture and medicine

(This special issue belongs to the Section Animal Science)

Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights

edited by

Geng-Long Hsu

and Yu-Ching Wen

submission deadline 30 Sep 2025 | 1 articles | Viewed by 838 | Submission Open

Keywords: testicular and Penile Disorders; testicle; physiology; infertility

(This special issue belongs to the Section Physiology and Pathology)

Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments

edited by Pedro Caravaca-Pérez and Jose Jesus Broseta

submission deadline 30 Sep 2025 | 1 articles | Viewed by 745 | Submission Open

Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment

(This special issue belongs to the Section Medical Research)

Advances in Livestock Breeding, Nutrition and Metabolism

edited by

Imran Khan

submission deadline 30 Sep 2025 | Viewed by 695 | Submission Open

Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability

(This special issue belongs to the Section Animal Science)

Research Progress of Cultivation of Edible Fungi: 2nd Edition

edited by Yajie Zou

submission deadline 30 Sep 2025 | 1 articles | Viewed by 669 | Submission Open

Keywords: edible fungi; cultivation; domesticate; substrate; biological efficiency; nutritional properties; functional compounds; sustainability; commercialization; emerging species

(This special issue belongs to the Section Microbiology)

Space Medicine Advancements: From Human Health to Biomedical System Design

edited by

Jiwoon Park

and

Atul Chander

submission deadline 30 Sep 2025 | 1 articles | Viewed by 402 | Submission Open

Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations

(This special issue belongs to the Section Medical Research)

Precision Therapies in Cancer: Advancements and Future Directions

edited by

Subhajit Chatterjee

and Krushna Chandra Hembram

submission deadline 30 Sep 2025 | Viewed by 370 | Submission Open

Keywords: precision oncology; cancer theragnostic; molecular targeting; immunotherapy

(This special issue belongs to the Section Medical Research)

New Developments in Mycology

edited by

Saul de la Peña-Lastra

submission deadline 30 Sep 2025 | Viewed by 310 | Submission Open

Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology

(This special issue belongs to the Section Microbiology)

Advances in Microvascular Research: 2nd Edition

edited by

Panagiota Anyfanti

and

Theodoros Dimitroulas

submission deadline 30 Sep 2025 | Viewed by 201 | Submission Open

Keywords: microvascular injury; microvascular dysfunction; microcirculation; vascular inflammation; hypertension; cardiovascular diseases

(This special issue belongs to the Section Physiology and Pathology)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Sep 2025 | Viewed by 183 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

Computational Approaches in Breast Cancer Diagnosis and Prognosis

edited by Elham Pashaei and

Jun Wan

submission deadline 30 Sep 2025 | Viewed by 151 | Submission Open

Keywords: bioinformatics; machine learning; artificial intelligence; breast cancer

(This special issue belongs to the Section Physiology and Pathology)

Advances in Congenital Diaphragmatic Hernia: From Clinical Features to Management

edited by Przemysław Kosinski

submission deadline 30 Sep 2025 | Viewed by 150 | Submission Open

Keywords: congenital diaphragmatic hernia; prenatal diagnosis; fetal interventions; neonatal management; pulmonary hypoplasia; surgical techniques; imaging techniques; genetic testing; FETO; comprehensive care protocols

(This special issue belongs to the Section Medical Research)

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