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Most Cited & Viewed - Cancers

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Citations	Article
405	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
292	Review: Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
281	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
191	Review: Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
165	Article: Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome by Marija Milacic, Robin Haw, Karen Rothfels, Guanming Wu, David Croft, Henning Hermjakob, Peter D'Eustachio and Lincoln Stein
140	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
110	Review: STAT3 Target Genes Relevant to Human Cancers by Richard L. Carpenter and Hui-Wen Lo
109	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
106	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
98	Review: Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin

Citations	Article
4	Article: A Phase II Study of Pelareorep (REOLYSIN^®) in Combination with Gemcitabine for Patients with Advanced Pancreatic Adenocarcinoma by Devalingam Mahalingam, Sanjay Goel, Santiago Aparo, Sukeshi Patel Arora, Nicole Noronha, Hue Tran, Romit Chakrabarty, Giovanni Selvaggi, Andres Gutierrez, Matthew Coffey, Steffan T. Nawrocki, Gerard Nuovo and Monica M. Mita
3	Review: The Osteoclast in Bone Metastasis: Player and Target by Antonio Maurizi and Nadia Rucci
2	Review: Designer Oncolytic Adenovirus: Coming of Age by Alexander T. Baker, Carmen Aguirre-Hernández, Gunnel Halldén and Alan L. Parker
2	Article: RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis by Alaa Zare, Alexandra Petrova, Mehdi Agoumi, Heather Armstrong, Gilbert Bigras, Katia Tonkin, Eytan Wine and Shairaz Baksh
2	Review: Targeted Tumor Therapy Remixed—An Update on the Use of Small-Molecule Drugs in Combination Therapies by Martina V. Gatzka
2	Review: The Endometriotic Tumor Microenvironment in Ovarian Cancer by Jillian R. Hufgard Wendel, Xiyin Wang and Shannon M. Hawkins
2	Editorial: Aptamers: Promising Tools for Cancer Diagnosis and Therapy by Laura Cerchia
2	Article: Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface by Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, Amaury Farce, Nicolas Renault, Frédéric Allemand, Jean-François Guichou, Anne-Sophie Drucbert, Catherine Foulon, Romain Magnez, Xavier Thuru, Matthieu Corvaisier, Guillemette Huet, Philippe Chavatte, Patricia Melnyk, Fabrice Bailly and Philippe Cotelle
2	Article: Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro by Rodolfo Garza-Morales, Roxana Gonzalez-Ramos, Akiko Chiba, Roberto Montes de Oca-Luna, Lacey R. McNally, Kelly M. McMasters and Jorge G. Gomez-Gutierrez
2	Perspective: Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on by Caterina Ledda, Paola Senia and Venerando Rapisarda

Citations	Article
20	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
16	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
14	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
13	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
11	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
10	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
8	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
7	Review: Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles by Ellas Spyratou, Mersini Makropoulou, Efstathios P. Efstathopoulos, Alexandros G. Georgakilas and Lembit Sihver
7	Review: mTOR Cross-Talk in Cancer and Potential for Combination Therapy by Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti and Michele Milella
6	Review: Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression by Ellie Rad, James T. Murray and Andrew R. Tee

Citations	Article
70	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
39	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
39	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
33	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
28	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
26	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
20	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
19	Review: Immunotherapy for Colorectal Cancer by Patrick M. Boland and Wen Wee Ma
18	Review: Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria P. Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou and Alexandros G. Georgakilas
17	Review: Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer by Kentaro Inamura

Citations	Article
109	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
106	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
70	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
47	Review: Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy by Anna Maria Barbuti and Zhe-Sheng Chen
41	Review: Oncogenic MicroRNAs: Key Players in Malignant Transformation by Tania Frixa, Sara Donzelli and Giovanni Blandino
41	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
39	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
39	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
37	Review: Wnt5a Signaling in Cancer by Marwa S. Asem, Steven Buechler, Rebecca Burkhalter Wates, Daniel L. Miller and M. Sharon Stack
33	Review: Cancer Stem Cell Plasticity Drives Therapeutic Resistance by Mary R. Doherty, Jacob M. Smigiel, Damian J. Junk and Mark W. Jackson

» More Articles

Views	Article
19661	Review: *Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
17410	Review: Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
17021	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
14412	Review: Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
14235	Review: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
12562	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
11811	Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? by Michael Retsky, Romano Demicheli, William Hrushesky, Michael Baum and Isaac Gukas
11771	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
11553	Review: The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer by Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani and Giuseppina Barrera
11209	Review: Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer by Michael J. Wargovich, Vondina R. Brown and Jay Morris

Views	Article
1795	Article: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes by Erico S. Teixeira, Karthik Uppulury, Austin J. Privett, Christopher Stopera, Patrick M. McLaurin and Jorge A. Morales
1753	Article: EBV Positive Diffuse Large B Cell Lymphoma and Chronic Lymphocytic Leukemia Patients Exhibit Increased Anti-dUTPase Antibodies by Marshall Williams and Maria Eugenia Ariza
1650	Article: Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface by Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, Amaury Farce, Nicolas Renault, Frédéric Allemand, Jean-François Guichou, Anne-Sophie Drucbert, Catherine Foulon, Romain Magnez, Xavier Thuru, Matthieu Corvaisier, Guillemette Huet, Philippe Chavatte, Patricia Melnyk, Fabrice Bailly and Philippe Cotelle
1638	Review: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting by Federica Lo Sardo, Sabrina Strano and Giovanni Blandino
1604	Article: Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment by Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop and Andrew R. Tee
1560	Review: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure by Eléonore Toufektchan and Franck Toledo
1530	Article: Oncolytic Reovirus and Immune Checkpoint Inhibition as a Novel Immunotherapeutic Strategy for Breast Cancer by Ahmed A. Mostafa, Daniel E. Meyers, Chandini M. Thirukkumaran, Peter J. Liu, Kathy Gratton, Jason Spurrell, Qiao Shi, Satbir Thakur and Don G. Morris
1485	Review: TGF-β in T Cell Biology: Implications for Cancer Immunotherapy by Amina Dahmani and Jean-Sébastien Delisle
1478	Review: Designer Oncolytic Adenovirus: Coming of Age by Alexander T. Baker, Carmen Aguirre-Hernández, Gunnel Halldén and Alan L. Parker
1394	Article: Frequency of EBV LMP-1 Promoter and Coding Variations in Burkitt Lymphoma Samples in Africa and South America and Peripheral Blood in Uganda by Hsiao-Mei Liao, Hebing Liu, Heiyan Lei, Bingjie Li, Pei-Ju Chin, Shien Tsai, Kishor Bhatia, Marina Gutierrez, Sidnei Epelman, Robert J. Biggar, Francis Nkrumah, Janet Neequaye, Martin D. Ogwang, Steven J. Reynolds, Shyh-Ching Lo and Sam M. Mbulaiteye

Views	Article
3437	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
3226	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
3125	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
3088	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
3086	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
2684	Review: Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells by Yoshiaki Sunami, Artur Rebelo and Jörg Kleeff
2655	Editorial: JNK, p38, ERK, and SGK1 Inhibitors in Cancer by Jonas Cicenas, Egle Zalyte, Arnas Rimkus, Dalius Dapkus, Remigijus Noreika and Sigitas Urbonavicius
2620	Review: Colorectal Cancer and Alcohol Consumption—Populations to Molecules by Marco Rossi, Muhammad Jahanzaib Anwar, Ahmad Usman, Ali Keshavarzian and Faraz Bishehsari
2548	Review: Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles by Ellas Spyratou, Mersini Makropoulou, Efstathios P. Efstathopoulos, Alexandros G. Georgakilas and Lembit Sihver
2417	Review: Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer by Jiajia Zhang, Christopher L. Wolfgang and Lei Zheng

Views	Article
5002	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4922	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
3990	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
3729	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin
3639	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
3575	Review: HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance by Babak Nami and Zhixiang Wang
3551	Review: Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy by Vito Cucchiara, Joy C. Yang, Vincenzo Mirone, Allen C. Gao, Michael G. Rosenfeld and Christopher P. Evans
3507	Review: Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions by Shilpa Gupta, David Gill, Austin Poole and Neeraj Agarwal
3476	Review: The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer by Brock J. Sishc and Anthony J. Davis
3437	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine

Views	Article
9099	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
8265	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
5002	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4922	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
4277	Review: Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma by Evan F. Garner and Elizabeth A. Beierle
4119	Review: Melanoma Cancer Stem Cells: Markers and Functions by Giorgio Parmiani
4078	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
4050	Review: Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer by Huai-Xiang Hao, Xiaomo Jiang and Feng Cong
3990	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
3980	Review: Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H₂O₂ Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons by Yasuhiro Ogawa

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