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Most Cited & Viewed - Cancers

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Citations	Article
390	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
270	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
260	Review: Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
188	Review: Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
163	Article: Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome by Marija Milacic, Robin Haw, Karen Rothfels, Guanming Wu, David Croft, Henning Hermjakob, Peter D'Eustachio and Lincoln Stein
139	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
106	Review: STAT3 Target Genes Relevant to Human Cancers by Richard L. Carpenter and Hui-Wen Lo
105	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
101	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
94	Review: Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin

Citations	Article
4	Review: YAP/TAZ Activation as a Target for Treating Metastatic Cancer by Janine S. A. Warren, Yuxuan Xiao and John M. Lamar
3	Review: Inhibiting TRK Proteins in Clinical Cancer Therapy by Allison M. Lange and Hui-Wen Lo
3	Article: A Phase II Study of Pelareorep (REOLYSIN^®) in Combination with Gemcitabine for Patients with Advanced Pancreatic Adenocarcinoma by Devalingam Mahalingam, Sanjay Goel, Santiago Aparo, Sukeshi Patel Arora, Nicole Noronha, Hue Tran, Romit Chakrabarty, Giovanni Selvaggi, Andres Gutierrez, Matthew Coffey, Steffan T. Nawrocki, Gerard Nuovo and Monica M. Mita
2	Review: Targeted Tumor Therapy Remixed—An Update on the Use of Small-Molecule Drugs in Combination Therapies by Martina V. Gatzka
2	Review: Bladder Cancer: New Insights into Its Molecular Pathology by Kentaro Inamura
2	Review: The Osteoclast in Bone Metastasis: Player and Target by Antonio Maurizi and Nadia Rucci
2	Review: The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies by Brianna M. Craver, Kenza El Alaoui, Robyn M. Scherber and Angela G. Fleischman
2	Article: Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro by Rodolfo Garza-Morales, Roxana Gonzalez-Ramos, Akiko Chiba, Roberto Montes de Oca-Luna, Lacey R. McNally, Kelly M. McMasters and Jorge G. Gomez-Gutierrez
2	Perspective: Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on by Caterina Ledda, Paola Senia and Venerando Rapisarda
2	Article: NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance by Javadi Monisha, Nand Kishor Roy, Ganesan Padmavathi, Kishore Banik, Devivasha Bordoloi, Amrita Devi Khwairakpam, Frank Arfuso, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Gautam Sethi, Alan Prem Kumar and Ajaikumar B. Kunnumakkara

Citations	Article
18	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
14	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
12	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
11	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
10	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
10	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
7	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
7	Review: mTOR Cross-Talk in Cancer and Potential for Combination Therapy by Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti and Michele Milella
6	Review: Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression by Ellie Rad, James T. Murray and Andrew R. Tee
6	Review: Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles by Ellas Spyratou, Mersini Makropoulou, Efstathios P. Efstathopoulos, Alexandros G. Georgakilas and Lembit Sihver

Citations	Article
63	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
37	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
29	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
27	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
26	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
23	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
18	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
17	Review: Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer by Kentaro Inamura
16	Review: Androgen Receptor: A Complex Therapeutic Target for Breast Cancer by Ramesh Narayanan and James T. Dalton
16	Review: Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria P. Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou and Alexandros G. Georgakilas

Citations	Article
105	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
101	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
63	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
47	Review: Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy by Anna Maria Barbuti and Zhe-Sheng Chen
46	Review: The Clinical Relevance of Long Non-Coding RNAs in Cancer by Andreia Silva, Marc Bullock and George Calin
44	Review: Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges by Rajyalakshmi Luthra, Hui Chen, Sinchita Roy-Chowdhuri and R. Rajesh Singh
41	Review: The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer by David P. Rose, Peter J. Gracheck and Linda Vona-Davis
39	Review: Oncogenic MicroRNAs: Key Players in Malignant Transformation by Tania Frixa, Sara Donzelli and Giovanni Blandino
39	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
37	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung

» More Articles

Views	Article
19603	Review: *Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
17288	Review: Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
16809	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
14319	Review: Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
14140	Review: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
12475	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
11734	Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? by Michael Retsky, Romano Demicheli, William Hrushesky, Michael Baum and Isaac Gukas
11671	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
11473	Review: The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer by Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani and Giuseppina Barrera
11129	Review: Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer by Michael J. Wargovich, Vondina R. Brown and Jay Morris

Views	Article
2046	Review: Bladder Cancer: New Insights into Its Molecular Pathology by Kentaro Inamura
1740	Article: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes by Erico S. Teixeira, Karthik Uppulury, Austin J. Privett, Christopher Stopera, Patrick M. McLaurin and Jorge A. Morales
1701	Article: EBV Positive Diffuse Large B Cell Lymphoma and Chronic Lymphocytic Leukemia Patients Exhibit Increased Anti-dUTPase Antibodies by Marshall Williams and Maria Eugenia Ariza
1588	Review: The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL) by Ivonne A. Montes-Mojarro, Julia Steinhilber, Irina Bonzheim, Leticia Quintanilla-Martinez and Falko Fend
1574	Review: Oncolytic Virotherapy versus Cancer Stem Cells: A Review of Approaches and Mechanisms by Shyambabu Chaurasiya, Nanhai G. Chen and Susanne G. Warner
1567	Article: Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface by Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, Amaury Farce, Nicolas Renault, Frédéric Allemand, Jean-François Guichou, Anne-Sophie Drucbert, Catherine Foulon, Romain Magnez, Xavier Thuru, Matthieu Corvaisier, Guillemette Huet, Philippe Chavatte, Patricia Melnyk, Fabrice Bailly and Philippe Cotelle
1547	Review: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting by Federica Lo Sardo, Sabrina Strano and Giovanni Blandino
1545	Review: Epigenetic Modifications as Biomarkers of Tumor Development, Therapy Response, and Recurrence across the Cancer Care Continuum by Margaret L. Thomas and Paola Marcato
1518	Article: EBV⁺ and MSI Gastric Cancers Harbor High PD-L1/PD-1 Expression and High CD8⁺ Intratumoral Lymphocytes by Simona De Rosa, Nora Sahnane, Maria Grazia Tibiletti, Francesca Magnoli, Alessandro Vanoli, Fausto Sessa and Anna Maria Chiaravalli
1476	Review: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure by Eléonore Toufektchan and Franck Toledo

Views	Article
3313	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
3177	Article: CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth by Vita Golubovskaya, Robert Berahovich, Hua Zhou, Shirley Xu, Hizkia Harto, Le Li, Cheng-Chi Chao, Mike Ming Mao and Lijun Wu
3062	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
2928	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
2917	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
2876	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
2752	Article: Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women by Yanyuan Wu, Marianna Sarkissyan, Sheilah Clayton, Rowan Chlebowski and Jaydutt V. Vadgama
2607	Review: Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells by Yoshiaki Sunami, Artur Rebelo and Jörg Kleeff
2502	Review: Colorectal Cancer and Alcohol Consumption—Populations to Molecules by Marco Rossi, Muhammad Jahanzaib Anwar, Ahmad Usman, Ali Keshavarzian and Faraz Bishehsari
2475	Editorial: JNK, p38, ERK, and SGK1 Inhibitors in Cancer by Jonas Cicenas, Egle Zalyte, Arnas Rimkus, Dalius Dapkus, Remigijus Noreika and Sigitas Urbonavicius

Views	Article
4810	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4631	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
3921	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
3556	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin
3469	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
3449	Review: Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy by Vito Cucchiara, Joy C. Yang, Vincenzo Mirone, Allen C. Gao, Michael G. Rosenfeld and Christopher P. Evans
3442	Review: HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance by Babak Nami and Zhixiang Wang
3388	Review: Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions by Shilpa Gupta, David Gill, Austin Poole and Neeraj Agarwal
3361	Review: The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer by Brock J. Sishc and Anthony J. Davis
3313	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine

Views	Article
8726	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
8018	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
4903	Review: Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges by Rajyalakshmi Luthra, Hui Chen, Sinchita Roy-Chowdhuri and R. Rajesh Singh
4810	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4631	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
4174	Review: The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer by David P. Rose, Peter J. Gracheck and Linda Vona-Davis
4154	Review: Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma by Evan F. Garner and Elizabeth A. Beierle
4069	Review: Melanoma Cancer Stem Cells: Markers and Functions by Giorgio Parmiani
3949	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
3921	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy

» More Articles

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