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Most Cited & Viewed - Cancers

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Citations	Article
448	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
360	Review: Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
321	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
203	Review: Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
171	Article: Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome by Marija Milacic, Robin Haw, Karen Rothfels, Guanming Wu, David Croft, Henning Hermjakob, Peter D'Eustachio and Lincoln Stein
146	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
132	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
129	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
126	Review: STAT3 Target Genes Relevant to Human Cancers by Richard L. Carpenter and Hui-Wen Lo
115	Review: Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin

Citations	Article
10	Review: Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy by Sonali Bhattacharjee and Saikat Nandi
8	Article: Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes by Mariantonia Logozzi, Davide Mizzoni, Daniela F. Angelini, Rossella Di Raimo, Mario Falchi, Luca Battistini and Stefano Fais
7	Review: The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies by Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng and Gautam Sethi
4	Article: Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma by Marius Ilié, Mélanie Beaulande, Saima Ben Hadj, Emmanuel Chamorey, Renaud Schiappa, Elodie Long-Mira, Sandra Lassalle, Catherine Butori, Charlotte Cohen, Sylvie Leroy, Olivier Guérin, Jérôme Mouroux, Charles-Hugo Marquette, Jean-François Pomerol, Gilles Erb, Véronique Hofman and Paul Hofman
4	Review: Systemic Therapy for Hepatocellular Carcinoma: Latest Advances by Masatoshi Kudo
4	Review: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers by Elizabeth Varghese, Samson Mathews Samuel, Mariam Abotaleb, Sohaila Cheema, Ravinder Mamtani and Dietrich Büsselberg
4	Review: Sensitization of Drug Resistant Cancer Cells: A Matter of Combination Therapy by Meghan Leary, Sarah Heerboth, Karolina Lapinska and Sibaji Sarkar
3	Review: Regulation of Ovarian Cancer Prognosis by Immune Cells in the Tumor Microenvironment by Maureen L. Drakes and Patrick J. Stiff
3	Article: Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells by Gaetano Verde, Lara I. De Llobet, Roni H.G. Wright, Javier Quilez, Sandra Peiró, François Le Dily and Miguel Beato
3	Article: Gap Junction Intercellular Communication Positively Regulates Cisplatin Toxicity by Inducing DNA Damage through Bystander Signaling by Sanjeevani Arora, Joshua R. Heyza, Elaine C. Chalfin, Randall J. Ruch and Steve M. Patrick

Citations	Article
11	Review: Inhibiting TRK Proteins in Clinical Cancer Therapy by Allison M. Lange and Hui-Wen Lo
10	Review: Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy by Sonali Bhattacharjee and Saikat Nandi
9	Review: Aptamer Therapeutics in Cancer: Current and Future by Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, David E. Volk and Takemi Tanaka
9	Review: 40 Years of Research Put p53 in Translation by Virginie Marcel, Flora Nguyen Van Long and Jean-Jacques Diaz
8	Review: Targeted Tumor Therapy Remixed—An Update on the Use of Small-Molecule Drugs in Combination Therapies by Martina V. Gatzka
8	Review: Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors by Jeffrey K. Holden and Christian N. Cunningham
8	Review: Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation by Matthew G.K. Benesch, Iain T.K. MacIntyre, Todd P.W. McMullen and David N. Brindley
8	Article: Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes by Mariantonia Logozzi, Davide Mizzoni, Daniela F. Angelini, Rossella Di Raimo, Mario Falchi, Luca Battistini and Stefano Fais
7	Review: The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies by Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng and Gautam Sethi
7	Review: YAP/TAZ Activation as a Target for Treating Metastatic Cancer by Janine S. A. Warren, Yuxuan Xiao and John M. Lamar

Citations	Article
69	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
39	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
36	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
32	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
29	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
26	Review: Immunotherapy for Colorectal Cancer by Patrick M. Boland and Wen Wee Ma
24	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
24	Review: Targeting the ATR-CHK1 Axis in Cancer Therapy by Stuart Rundle, Alice Bradbury, Yvette Drew and Nicola J. Curtin
23	Review: Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria P. Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou and Alexandros G. Georgakilas
22	Review: MicroRNAs as Biomarkers in Colorectal Cancer by Takaaki Masuda, Naoki Hayashi, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi and Koshi Mimori

Citations	Article
88	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian Van Straten, Vida Mashayekhi, Henriette S. De Bruijn, Sabrina Oliveira and Dominic J. Robinson
69	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
52	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
48	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
39	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
39	Review: Wnt5a Signaling in Cancer by Marwa S. Asem, Steven Buechler, Rebecca Burkhalter Wates, Daniel L. Miller and M. Sharon Stack
38	Review: KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment by Daniel Zeitouni, Yuliya Pylayeva-Gupta, Channing J. Der and Kirsten L. Bryant
36	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
33	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
32	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta

» More Articles

Views	Article
19873	Review: *Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
17774	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
17739	Review: Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
14678	Review: Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
14516	Review: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
12793	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
12078	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
12040	Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? by Michael Retsky, Romano Demicheli, William Hrushesky, Michael Baum and Isaac Gukas
11804	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
11785	Review: The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer by Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani and Giuseppina Barrera

Views	Article
1962	Article: Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment by Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop and Andrew R. Tee
1890	Review: Gut Microbiota and Cancer: From Pathogenesis to Therapy by Silvia Vivarelli, Rossella Salemi, Saverio Candido, Luca Falzone, Maria Santagati, Stefania Stefani, Francesco Torino, Giuseppe Luigi Banna, Giuseppe Tonini and Massimo Libra
1735	Review: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers by Elizabeth Varghese, Samson Mathews Samuel, Mariam Abotaleb, Sohaila Cheema, Ravinder Mamtani and Dietrich Büsselberg
1664	Article: CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth by Robert Berahovich, Hua Zhou, Shirley Xu, Yuehua Wei, Jasper Guan, Jian Guan, Hizkia Harto, Shuxiang Fu, Kaihuai Yang, Shuying Zhu, Le Li, Lijun Wu and Vita Golubovskaya
1645	Review: Systemic Therapy for Hepatocellular Carcinoma: Latest Advances by Masatoshi Kudo
1554	Review: NK Cell-Based Immunotherapy in Cancer Metastasis by Seila Lorenzo-Herrero, Alejandro López-Soto, Christian Sordo-Bahamonde, Ana P Gonzalez-Rodriguez, Massimo Vitale and Segundo Gonzalez
1279	Review: Non-Coding RNAs in Glioma by Ryte Rynkeviciene, Julija Simiene, Egle Strainiene, Vaidotas Stankevicius, Jurgita Usinskiene, Edita Miseikyte Kaubriene, Ingrida Meskinyte, Jonas Cicenas and Kestutis Suziedelis
1270	Review: The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers by Ibrahim Ragab Eissa, Itzel Bustos-Villalobos, Toru Ichinose, Shigeru Matsumura, Yoshinori Naoe, Noriyuki Miyajima, Daishi Morimoto, Nobuaki Mukoyama, Wu Zhiwen, Maki Tanaka, Hitoki Hasegawa, Seiji Sumigama, Branko Aleksic, Yasuhiro Kodera and Hideki Kasuya
1228	Review: Repurposing of Drugs Targeting YAP-TEAD Functions by Gian Marco Elisi, Matteo Santucci, Domenico D’Arca, Angela Lauriola, Gaetano Marverti, Lorena Losi, Laura Scalvini, Maria Laura Bolognesi, Marco Mor and Maria Paola Costi
1223	Review: Epidemiology of Moderate Alcohol Consumption and Breast Cancer: Association or Causation? by Samir Zakhari and Jan B. Hoek

Views	Article
3806	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
2615	Review: The Hippo Pathway: Immunity and Cancer by Zaid Taha, Helena J. Janse van Rensburg and Xiaolong Yang
2461	Review: Update on Immunohistochemistry for the Diagnosis of Lung Cancer by Kentaro Inamura
2434	Review: The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis by Abigail Morales-Sánchez and Ezequiel M. Fuentes-Panana
2415	Review: Bladder Cancer: New Insights into Its Molecular Pathology by Kentaro Inamura
2316	Review: The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas by Ines Garces de los Fayos Alonso, Huan-Chang Liang, Suzanne D. Turner, Sabine Lagger, Olaf Merkel and Lukas Kenner
2257	Review: Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors by Jeffrey K. Holden and Christian N. Cunningham
2058	Review: Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond by Nina Prokoph, Hugo Larose, Megan S. Lim, G. A. Amos Burke and Suzanne D. Turner
2033	Review: Aptamer Therapeutics in Cancer: Current and Future by Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, David E. Volk and Takemi Tanaka
1993	Article: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes by Erico S. Teixeira, Karthik Uppulury, Austin J. Privett, Christopher Stopera, Patrick M. McLaurin and Jorge A. Morales

Views	Article
5765	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
5327	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4138	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
3991	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
3989	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
3973	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
3957	Review: Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors by Joline S. J. Lim and David S. P. Tan
3955	Review: HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance by Babak Nami and Zhixiang Wang
3825	Article: CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth by Vita Golubovskaya, Robert Berahovich, Hua Zhou, Shirley Xu, Hizkia Harto, Le Li, Cheng-Chi Chao, Mike Ming Mao and Lijun Wu
3806	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine

Views	Article
9117	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
5765	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
5327	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4574	Review: Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer by Huai-Xiang Hao, Xiaomo Jiang and Feng Cong
4393	Review: KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment by Daniel Zeitouni, Yuliya Pylayeva-Gupta, Channing J. Der and Kirsten L. Bryant
4360	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin
4320	Review: Melanoma Cancer Stem Cells: Markers and Functions by Giorgio Parmiani
4252	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
4138	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
3991	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura

» More Articles

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