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Citations	Article
723	Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
672	Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
504	Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
309	Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
275	Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
236	Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
224	Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
221	Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
221	Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin
215	Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian Van Straten, Vida Mashayekhi, Henriette S. De Bruijn, Sabrina Oliveira and Dominic J. Robinson

Citations	Article
8	Cachexia and Sarcopenia in Older Adults with Cancer: A Comprehensive Review by Richard F. Dunne, Kah Poh Loh, Grant R. Williams, Aminah Jatoi, Karen M. Mustian and Supriya G. Mohile
7	Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials by Amaia Eleonora Maennling, Mehmet Kemal Tur, Marcus Niebert, Torsten Klockenbring, Felix Zeppernick, Stefan Gattenlöhner, Ivo Meinhold-Heerlein and Ahmad Fawzi Hussain
7	Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis by Jong Yeob Kim, Keum Hwa Lee, Jeonghyun Kang, Edith Borcoman, Esma Saada-Bouzid, Andreas Kronbichler, Sung Hwi Hong, Leandro Fórnias Machado de Rezende, Shuji Ogino, Nana Keum, Mingyang Song, Claudio Luchini, Hans J. van der Vliet, Jae Il Shin and Gabriele Gamerith
6	Direct Targeting Options for STAT3 and STAT5 in Cancer by Anna Orlova, Christina Wagner, Elvin D. de Araujo, Dávid Bajusz, Heidi A. Neubauer, Marco Herling, Patrick T. Gunning, György M. Keserű and Richard Moriggl
5	Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope by Lucia Salvioni, Maria Antonietta Rizzuto, Jessica Armida Bertolini, Laura Pandolfi, Miriam Colombo and Davide Prosperi
5	Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Spyridon A. Kalospyros and Alexandros G. Georgakilas
5	The Role and Function of microRNA in the Pathogenesis of Multiple Myeloma by Hiroshi Handa, Yuki Murakami, Rei Ishihara, Kei Kimura-Masuda and Yuta Masuda
4	Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma by Juliane Lokau, Victor Schoeder, Johannes Haybaeck and Christoph Garbers
4	Response to Lenvatinib Is Associated with Optimal RelativeDose Intensity in Hepatocellular Carcinoma: Experience in Clinical Settings by Ryu Sasaki, Masanori Fukushima, Masafumi Haraguchi, Satoshi Miuma, Hisamitsu Miyaaki, Masaaki Hidaka, Susumu Eguchi, Satoshi Matsuo, Kazuaki Tajima, Toshihisa Matsuzaki, Satsuki Hashimoto, Kazuo Ooba, Yuki Kugiyama, Hiroshi Yatsuhashi, Yasuhide Motoyoshi, Masaya Shigeno, Noboru Kinoshita and Kazuhiko Nakao
4	Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma by Francesca Bonello, Roberto Mina, Mario Boccadoro and Francesca Gay

Citations	Article
26	Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems by Jihye Yoo, Changhee Park, Gawon Yi, Donghyun Lee and Heebeom Koo
17	Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study by Antonella Argentiero, Simona De Summa, Roberta Di Fonte, Rosa Maria Iacobazzi, Letizia Porcelli, Matteo Da Vià, Oronzo Brunetti, Amalia Azzariti, Nicola Silvestris and Antonio Giovanni Solimando
17	Reactive Oxygen Species in the Tumor Microenvironment: An Overview by Frank Weinberg, Nithya Ramnath and Deepak Nagrath
16	Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Study by Kazuomi Ueshima, Naoshi Nishida, Satoru Hagiwara, Tomoko Aoki, Tomohiro Minami, Hirokazu Chishina, Masahiro Takita, Yasunori Minami, Hiroshi Ida, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Masahiro Morita, Chikara Ogawa, Atsushi Hiraoka, Philip Johnson and Masatoshi Kudo
15	Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy by Kyle B. Lupo and Sandro Matosevic
15	DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy by Beatriz Sanchez-Correa, Isabel Valhondo, Fakhri Hassouneh, Nelson Lopez-Sejas, Alejandra Pera, Juan M. Bergua, Maria Jose Arcos, Helena Bañas, Ignacio Casas-Avilés, Esther Durán, Corona Alonso, Rafael Solana and Raquel Tarazona
14	Targeting Cancer Stem Cells in Triple-Negative Breast Cancer by So-Yeon Park, Jang-Hyun Choi and Jeong-Seok Nam
14	Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression by Gabriella D’Orazi and Mara Cirone
13	PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences are Emerging—A Literature Review by Gabrielle Planes-Laine, Philippe Rochigneux, François Bertucci, Anne-Sophie Chrétien, Patrice Viens, Renaud Sabatier and Anthony Gonçalves
13	A Review of the Role of Wnt in Cancer Immunomodulation by Whitney N. Goldsberry, Angelina Londoño, Troy D. Randall, Lyse A. Norian and Rebecca C. Arend

Citations	Article
44	Systemic Therapy for Hepatocellular Carcinoma: Latest Advances by Masatoshi Kudo
43	Flavonoids in Cancer and Apoptosis by Mariam Abotaleb, Samson Mathews Samuel, Elizabeth Varghese, Sharon Varghese, Peter Kubatka, Alena Liskova and Dietrich Büsselberg
41	Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells by Ugo Testa, Germana Castelli and Elvira Pelosi
36	Gut Microbiota and Cancer: From Pathogenesis to Therapy by Silvia Vivarelli, Rossella Salemi, Saverio Candido, Luca Falzone, Maria Santagati, Stefania Stefani, Francesco Torino, Giuseppe Luigi Banna, Giuseppe Tonini and Massimo Libra
33	Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes by Mariantonia Logozzi, Davide Mizzoni, Daniela F. Angelini, Rossella Di Raimo, Mario Falchi, Luca Battistini and Stefano Fais
31	Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer by Luca Falzone, Gabriella Lupo, Giusy Rita Maria La Rosa, Salvatore Crimi, Carmelina Daniela Anfuso, Rossella Salemi, Ernesto Rapisarda, Massimo Libra and Saverio Candido
29	The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies by Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng and Gautam Sethi
29	*New Insights into Long Non-Coding RNA MALAT1* in Cancer and Metastasis** by Yutong Sun and Li Ma
29	Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors by Isabella Faraoni and Grazia Graziani
29	CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1 by Davide Barbagallo, Angela Caponnetto, Duilia Brex, Federica Mirabella, Cristina Barbagallo, Giovanni Lauretta, Antonio Morrone, Francesco Certo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. Barbagallo, Vittoria Spina-Purrello, Marco Ragusa, Cinzia Di Pietro, Thomas B. Hansen and Michele Purrello

Citations	Article
221	Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
85	Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
83	Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
79	mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
74	Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
59	Integrins as Therapeutic Targets: Successes and Cancers by Sabine Raab-Westphal, John F. Marshall and Simon L. Goodman
59	Immunotherapy for Colorectal Cancer by Patrick M. Boland and Wen Wee Ma
53	MicroRNAs as Biomarkers in Colorectal Cancer by Takaaki Masuda, Naoki Hayashi, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi and Koshi Mimori
50	EMT and Treatment Resistance in Pancreatic Cancer by Nicola Gaianigo, Davide Melisi and Carmine Carbone
49	Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou

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Views	Article
21236	Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
20603	*Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
19190	Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
15648	Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
15364	Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
15356	Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
14891	Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
14874	Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
13856	Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
13192	Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza

Views	Article
2027	Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment by Aleksei Titov, Aygul Valiullina, Ekaterina Zmievskaya, Ekaterina Zaikova, Alexey Petukhov, Regina Miftakhova, Emil Bulatov and Albert Rizvanov
1775	Rapid and Label-Free Isolation of Tumour Cells from the Urine of Patients with Localised Prostate Cancer Using Inertial Microfluidics by Alexey S. Rzhevskiy, Sajad Razavi Bazaz, Lin Ding, Alina Kapitannikova, Nima Sayyadi, Douglas Campbell, Bradley Walsh, David Gillatt, Majid Ebrahimi Warkiani and Andrei V. Zvyagin
1746	Ferroptosis in Cancer Cell Biology by Christina M. Bebber, Fabienne Müller, Laura Prieto Clemente, Josephine Weber and Silvia von Karstedt
1582	The Role of Nrf2 Activity in Cancer Development and Progression by Alina-Andreea Zimta, Diana Cenariu, Alexandru Irimie, Lorand Magdo, Seyed Mohammad Nabavi, Atanas G. Atanasov and Ioana Berindan-Neagoe
1449	Immunotherapy for Multiple Myeloma by Hideto Tamura, Mariko Ishibashi, Mika Sunakawa and Koiti Inokuchi
1394	Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma by Naoki Hosen
1371	Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma by Francesca Bonello, Roberto Mina, Mario Boccadoro and Francesca Gay
1295	Immunotherapy: A Challenge of Breast Cancer Treatment by Marilina García-Aranda and Maximino Redondo
1266	Characterization of Human NK Cell-Derived Exosomes: Role of DNAM1 Receptor in Exosome-Mediated Cytotoxicity against Tumor by Anna Laura Di Pace, Nicola Tumino, Francesca Besi, Claudia Alicata, Libenzio Adrian Conti, Enrico Munari, Enrico Maggi, Paola Vacca and Lorenzo Moretta
1255	Metformin as Potential Therapy for High-Grade Glioma by Marek Mazurek, Jakub Litak, Piotr Kamieniak, Bartłomiej Kulesza, Katarzyna Jonak, Jacek Baj and Cezary Grochowski

Views	Article
3010	*Intercellular Transfer of Oncogenic KRAS* via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells** by Snider Desir, Phillip Wong, Thomas Turbyville, De Chen, Mihir Shetty, Christopher Clark, Edward Zhai, Yevgeniy Romin, Katia Manova-Todorova, Timothy K. Starr, Dwight V. Nissley, Clifford J. Steer, Subbaya Subramanian and Emil Lou
2967	PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences are Emerging—A Literature Review by Gabrielle Planes-Laine, Philippe Rochigneux, François Bertucci, Anne-Sophie Chrétien, Patrice Viens, Renaud Sabatier and Anthony Gonçalves
2885	Lenvatinib as an Initial Treatment in Patients with Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven Criteria and Child–Pugh A Liver Function: A Proof-Of-Concept Study by Masatoshi Kudo, Kazuomi Ueshima, Stephan Chan, Tomohiro Minami, Hirokazu Chishina, Tomoko Aoki, Masahiro Takita, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Masahiro Morita, Chikara Ogawa, Yoshiyuki Wada, Masafumi Ikeda, Hiroshi Ishii, Namiki Izumi and Naoshi Nishida
2813	Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature by Andrea Emanuele Guerini, Luca Triggiani, Marta Maddalo, Marco Lorenzo Bonù, Francesco Frassine, Anna Baiguini, Alessandro Alghisi, Davide Tomasini, Paolo Borghetti, Nadia Pasinetti, Roberto Bresciani, Stefano Maria Magrini and Michela Buglione
2655	The Emerging Roles of mTORC1 in Macromanaging Autophagy by Akpedje S. Dossou and Alakananda Basu
2599	Mining Prognosis Index of Brain Metastases Using Artificial Intelligence by Shigao Huang, Jie Yang, Simon Fong and Qi Zhao
2508	Countering TRAIL Resistance in Melanoma by Jürgen Eberle
2500	Current Perspectives in Cancer Immunotherapy by Theodoulakis Christofi, Stavroula Baritaki, Luca Falzone, Massimo Libra and Apostolos Zaravinos
2405	Tebentafusp: T Cell Redirection for the Treatment of Metastatic Uveal Melanoma by Bertil E. Damato, Joseph Dukes, Howard Goodall and Richard D. Carvajal
2404	Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy by Sebastian Chrétien, Ioannis Zerdes, Jonas Bergh, Alexios Matikas and Theodoros Foukakis

Views	Article
9512	Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen by Koen G.A.M. Hussaarts, Daan P. Hurkmans, Esther Oomen-de Hoop, Leonie J. van Harten, Stan Berghuis, Robbert J. van Alphen, Leontine E.A. Spierings, Quirine C. van Rossum-Schornagel, Mijntje B. Vastbinder, Ron H.N. van Schaik, Teun van Gelder, Agnes Jager, Roelof W.F. van Leeuwen and Ron H.J. Mathijssen
5275	Gut Microbiota and Cancer: From Pathogenesis to Therapy by Silvia Vivarelli, Rossella Salemi, Saverio Candido, Luca Falzone, Maria Santagati, Stefania Stefani, Francesco Torino, Giuseppe Luigi Banna, Giuseppe Tonini and Massimo Libra
4088	YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting by Federica Lo Sardo, Sabrina Strano and Giovanni Blandino
3828	Designer Oncolytic Adenovirus: Coming of Age by Alexander T. Baker, Carmen Aguirre-Hernández, Gunnel Halldén and Alan L. Parker
3719	NK Cell-Based Immunotherapy in Cancer Metastasis by Seila Lorenzo-Herrero, Alejandro López-Soto, Christian Sordo-Bahamonde, Ana P Gonzalez-Rodriguez, Massimo Vitale and Segundo Gonzalez
3568	Flavonoids in Cancer and Apoptosis by Mariam Abotaleb, Samson Mathews Samuel, Elizabeth Varghese, Sharon Varghese, Peter Kubatka, Alena Liskova and Dietrich Büsselberg
3403	Systemic Therapy for Hepatocellular Carcinoma: Latest Advances by Masatoshi Kudo
3200	The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer? by David E. Moulder, Diana Hatoum, Enoch Tay, Yiguang Lin and Eileen M. McGowan
3194	Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment by Norbaini Binti Abdol Razak, Gabrielle Jones, Mayank Bhandari, Michael C. Berndt and Pat Metharom
3173	Oncolytic Reovirus and Immune Checkpoint Inhibition as a Novel Immunotherapeutic Strategy for Breast Cancer by Ahmed A. Mostafa, Daniel E. Meyers, Chandini M. Thirukkumaran, Peter J. Liu, Kathy Gratton, Jason Spurrell, Qiao Shi, Satbir Thakur and Don G. Morris

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10114	Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
9512	Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen by Koen G.A.M. Hussaarts, Daan P. Hurkmans, Esther Oomen-de Hoop, Leonie J. van Harten, Stan Berghuis, Robbert J. van Alphen, Leontine E.A. Spierings, Quirine C. van Rossum-Schornagel, Mijntje B. Vastbinder, Ron H.N. van Schaik, Teun van Gelder, Agnes Jager, Roelof W.F. van Leeuwen and Ron H.J. Mathijssen
8175	Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
6936	Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
6754	mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
6234	Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
6147	Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
5723	Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
5634	Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors by Joline S. J. Lim and David S. P. Tan
5530	Complex Determinants of Epithelial: Mesenchymal Phenotypic Plasticity in Ovarian Cancer by Yuliya Klymenko, Oleg Kim and M. Sharon Stack

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