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Most Cited & Viewed - Cancers

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Citations	Article
419	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
322	Review: Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
300	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
193	Review: Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
168	Article: Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome by Marija Milacic, Robin Haw, Karen Rothfels, Guanming Wu, David Croft, Henning Hermjakob, Peter D'Eustachio and Lincoln Stein
144	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
121	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
118	Review: STAT3 Target Genes Relevant to Human Cancers by Richard L. Carpenter and Hui-Wen Lo
115	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
108	Review: Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin

Citations	Article
6	Review: Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy by Sonali Bhattacharjee and Saikat Nandi
4	Review: The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies by Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng and Gautam Sethi
3	Review: The Endometriotic Tumor Microenvironment in Ovarian Cancer by Jillian R. Hufgard Wendel, Xiyin Wang and Shannon M. Hawkins
3	Review: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers by Elizabeth Varghese, Samson Mathews Samuel, Mariam Abotaleb, Sohaila Cheema, Ravinder Mamtani and Dietrich Büsselberg
3	Review: Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy by Nemany A. N. Hanafy, Maged El-Kemary and Stefano Leporatti
3	Review: The Tumor Microenvironment of Epithelial Ovarian Cancer and Its Influence on Response to Immunotherapy by Galaxia M. Rodriguez, Kristianne J. C. Galpin, Curtis W. McCloskey and Barbara C. Vanderhyden
2	Review: Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers by Nisansala Chandimali, Dong Kee Jeong and Taeho Kwon
2	Review: Regulation of Ovarian Cancer Prognosis by Immune Cells in the Tumor Microenvironment by Maureen L. Drakes and Patrick J. Stiff
2	Review: UnPAXing the Divergent Roles of PAX2 and PAX8 in High-Grade Serous Ovarian Cancer by Laura R. Hardy, Amrita Salvi and Joanna E. Burdette
2	Review: Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression by Subramanyam Dasari, Yiming Fang and Anirban K. Mitra

Citations	Article
19	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
15	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
14	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
13	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
11	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
9	Review: Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review by Xuehui Pang, Cheng Cui, Shuo Wan, Ying Jiang, Liangliang Zhang, Lian Xia, Long Li, Xiaowei Li and Weihong Tan
8	Review: Inhibiting TRK Proteins in Clinical Cancer Therapy by Allison M. Lange and Hui-Wen Lo
8	Review: mTOR Cross-Talk in Cancer and Potential for Combination Therapy by Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti and Michele Milella
7	Review: Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression by Ellie Rad, James T. Murray and Andrew R. Tee
7	Review: Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation by Matthew G.K. Benesch, Iain T.K. MacIntyre, Todd P.W. McMullen and David N. Brindley

Citations	Article
75	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian Van Straten, Vida Mashayekhi, Henriette S. De Bruijn, Sabrina Oliveira and Dominic J. Robinson
53	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
45	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
36	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
30	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
27	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
22	Review: Targeting the ATR-CHK1 Axis in Cancer Therapy by Stuart Rundle, Alice Bradbury, Yvette Drew and Nicola J. Curtin
21	Review: Immunotherapy for Colorectal Cancer by Patrick M. Boland and Wen Wee Ma
20	Review: Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria P. Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou and Alexandros G. Georgakilas
19	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug

Citations	Article
115	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
75	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian Van Straten, Vida Mashayekhi, Henriette S. De Bruijn, Sabrina Oliveira and Dominic J. Robinson
53	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
45	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
45	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
39	Review: Wnt5a Signaling in Cancer by Marwa S. Asem, Steven Buechler, Rebecca Burkhalter Wates, Daniel L. Miller and M. Sharon Stack
36	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
35	Review: Cancer Stem Cell Plasticity Drives Therapeutic Resistance by Mary R. Doherty, Jacob M. Smigiel, Damian J. Junk and Mark W. Jackson
32	Review: KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment by Daniel Zeitouni, Yuliya Pylayeva-Gupta, Channing J. Der and Kirsten L. Bryant
30	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler

» More Articles

Views	Article
19782	Review: *Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
17585	Review: Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
17345	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
14547	Review: Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
14383	Review: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
12669	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
11926	Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? by Michael Retsky, Romano Demicheli, William Hrushesky, Michael Baum and Isaac Gukas
11917	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
11685	Review: The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer by Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani and Giuseppina Barrera
11434	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano

Views	Article
1821	Article: Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment by Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop and Andrew R. Tee
1527	Review: The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers by Elizabeth Varghese, Samson Mathews Samuel, Mariam Abotaleb, Sohaila Cheema, Ravinder Mamtani and Dietrich Büsselberg
1423	Article: CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth by Robert Berahovich, Hua Zhou, Shirley Xu, Yuehua Wei, Jasper Guan, Jian Guan, Hizkia Harto, Shuxiang Fu, Kaihuai Yang, Shuying Zhu, Le Li, Lijun Wu and Vita Golubovskaya
1414	Review: Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells by Ugo Testa, Germana Castelli and Elvira Pelosi
1398	Review: The Tumor Microenvironment of Epithelial Ovarian Cancer and Its Influence on Response to Immunotherapy by Galaxia M. Rodriguez, Kristianne J. C. Galpin, Curtis W. McCloskey and Barbara C. Vanderhyden
1343	Review: Systemic Therapy for Hepatocellular Carcinoma: Latest Advances by Masatoshi Kudo
1271	Review: Current Molecular-Targeted Therapies in NSCLC and Their Mechanism of Resistance by Zachary Schrank, Gagan Chhabra, Leo Lin, Tsatsral Iderzorig, Chike Osude, Nabiha Khan, Adijan Kuckovic, Sanjana Singh, Rachel J. Miller and Neelu Puri
1257	Review: Radiation Pneumonitis: Old Problem, New Tricks by Varsha Jain and Abigail T. Berman
1222	Review: The Role of Direct Oral Anticoagulants in Treatment of Cancer-Associated Thrombosis by Hanny Al-Samkari and Jean M. Connors
1214	Review: Epithelioid Hemangioendothelioma as a Model of YAP/TAZ-Driven Cancer: Insights from a Rare Fusion Sarcoma by John M. Lamar, Vijeyaluxmy Motilal Nehru and Guy Weinberg

Views	Article
3633	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
3526	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
3519	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
3435	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
2914	Review: Colorectal Cancer and Alcohol Consumption—Populations to Molecules by Marco Rossi, Muhammad Jahanzaib Anwar, Ahmad Usman, Ali Keshavarzian and Faraz Bishehsari
2637	Review: Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer by Jiajia Zhang, Christopher L. Wolfgang and Lei Zheng
2489	Review: The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer by Sandra Valle, Laura Martin-Hijano, Sonia Alcalá, Marta Alonso-Nocelo and Bruno Sainz Jr.
2475	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
2462	Review: The Hippo Pathway: Immunity and Cancer by Zaid Taha, Helena J. Janse van Rensburg and Xiaolong Yang
2404	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro

Views	Article
5373	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
5163	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4024	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin
3869	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
3764	Review: HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance by Babak Nami and Zhixiang Wang
3726	Review: Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy by Vito Cucchiara, Joy C. Yang, Vincenzo Mirone, Allen C. Gao, Michael G. Rosenfeld and Christopher P. Evans
3678	Review: Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions by Shilpa Gupta, David Gill, Austin Poole and Neeraj Agarwal
3645	Review: The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer by Brock J. Sishc and Anthony J. Davis
3633	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
3605	Review: Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors by Joline S. J. Lim and David S. P. Tan

Views	Article
9745	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
8643	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
5373	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
5163	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
4330	Review: Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer by Huai-Xiang Hao, Xiaomo Jiang and Feng Cong
4217	Review: Melanoma Cancer Stem Cells: Markers and Functions by Giorgio Parmiani
4121	Review: Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H₂O₂ Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons by Yasuhiro Ogawa
4121	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
4110	Review: KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment by Daniel Zeitouni, Yuliya Pylayeva-Gupta, Channing J. Der and Kirsten L. Bryant
4024	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin

» More Articles

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