Flavonoids in Cancer and Apoptosis
Mariam Abotaleb 1, Samson Mathews Samuel 1
, Elizabeth Varghese 1, Sharon Varghese 1, Peter Kubatka 2, Alena Liskova 3 and Dietrich Büsselberg 1,*
, Elizabeth Varghese 1, Sharon Varghese 1, Peter Kubatka 2, Alena Liskova 3 and Dietrich Büsselberg 1,*
1
Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, P.O. Box 24144, Qatar
2
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia
3
Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(1), 28; https://doi.org/10.3390/cancers11010028
Received: 22 November 2018 / Revised: 12 December 2018 / Accepted: 13 December 2018 / Published: 28 December 2018
Abstract
Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed. View Full-TextKeywords:
anti-cancer therapy; apoptosis; cancer; flavonoids; natural compounds; phytochemicals
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Abotaleb, M.; Samuel, S.M.; Varghese, E.; Varghese, S.; Kubatka, P.; Liskova, A.; Büsselberg, D. Flavonoids in Cancer and Apoptosis. Cancers 2019, 11, 28.
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