Non-canonical Kinases and Substrates in Cancer Progression
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 61444
Special Issue Editor
Interests: cancer; metastasis; adhesion; cell migration; Rho GTPases; neuroblastoma; cellular signalling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein Ser/Thr or Tyr kinases mediate most signal transduction pathways in eukaryotic cells, being the favourite post translational modification for situations where a rapid response to extracellular or intracellular signalling is required. Many of the known oncogenic proteins are kinases and many tumour suppressor proteins are among their substrates. More than 15 years after the publication by Manning et al. of their landmark paper describing the human kinome, only a small proportion of the kinases potentially involved in cancer progression have received most of the attention. Moreover, only a few of the potential targets have been investigated in their cellular context. With an ever-pressing need for new druggable targets, the understanding of the biological function and contribution to cancer progression of the lesser known cancer-related kinases represents an unavoidable asset.
This special issue of Cancers pretends to bring together the latest views and original research on non-canonical protein kinases, substrates and scaffolds. Topics might include protein structure and regulation; scaffolding and complex formation; cellular signalling; non-canonical substrates; inhibition and targeting; biological function, etc.
Dr. Francisco M. Vega
Guest Editor
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Keywords
- protein structure and regulation
- scaffolding and complex formation
- cellular signalling
- non-canonical substrates
- inhibition and targeting
- biological function
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