Non-canonical Kinases and Substrates in Cancer Progression

Dear Colleagues,

Protein Ser/Thr or Tyr kinases mediate most signal transduction pathways in eukaryotic cells, being the favourite post translational modification for situations where a rapid response to extracellular or intracellular signalling is required. Many of the known oncogenic proteins are kinases and many tumour suppressor proteins are among their substrates. More than 15 years after the publication by Manning et al. of their landmark paper describing the human kinome, only a small proportion of the kinases potentially involved in cancer progression have received most of the attention. Moreover, only a few of the potential targets have been investigated in their cellular context. With an ever-pressing need for new druggable targets, the understanding of the biological function and contribution to cancer progression of the lesser known cancer-related kinases represents an unavoidable asset.

This special issue of Cancers pretends to bring together the latest views and original research on non-canonical protein kinases, substrates and scaffolds. Topics might include protein structure and regulation; scaffolding and complex formation; cellular signalling; non-canonical substrates; inhibition and targeting; biological function, etc.

Dr. Francisco M. Vega
Guest Editor

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