Special Issue "Cancer-Associated Fibroblasts"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 July 2015)
Dr. Huey-Jen Lin
Department of Medical Laboratory Sciences, College of Health Sciences, University of Delaware, Newark, DE 19716, USA
Website | E-Mail
Interests: DNA methylation; cancer invasion and metastasis in breast and pancreatic cancers; carcinoma-associated fibroblasts; epithelial-mesenchymal transition; AKT signaling pathway
During cancer progression, tumor cells secrete signaling molecules that influence the surrounding non-malignant cells that are collectively known as stroma or tumor microenvironment. Tumor stromal cells further favor tumor cell growth, survival, migration, invasion, micro-metastasis and colonization, as well as initiation of blood brain barrier transmigration. The malignant properties of growth, invasiveness, metastasis, and susceptibility to chemotherapeutic drugs are determined not only by cancer cells themselves, but also by the stromal microenvironment. Carcinoma-associated fibroblasts (CAFs) are the most active secretory and abundant population among the non-cancerous stromal cells, and CAFs are often associated with poor clinical prognosis. CAFs actively participate in tumor growth and metastasis by production of growth factors, metaloproteases, cytokines, chemokines, microRNA and the release of pro-inflammatory and pro-angiogenic factors. The roles that CAFs play during the initiation and progression of carcinogenesis are thought to be of critical importance, both for the enhanced understanding of fundamental cancer biology as well as for improving molecular diagnostics and therapeutics. Stromal fibroblasts have become one of the important predictors of disease-related mortality or efficacy of drug treatment. This Special Issue focuses on novel advances in understanding how CAFs provide cancer cells with a supportive microenvironment, as well as on the development of novel therapeutic regimens by abrogating the vicious cycle of tumor-stromal interactions.
Dr. Huey-Jen Lin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cancer-associated fibroblasts
- signal transduction pathways
- susceptibility to anti-cancer drugs
- tumor microenvironment
- tumor invasion and metastasis