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Open AccessReview

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

1
Division of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
2
VA Ann Arbor Health Care System, Ann Arbor, MI 48109, USA
3
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
4
Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA
5
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1191; https://doi.org/10.3390/cancers11081191
Received: 1 July 2019 / Revised: 6 August 2019 / Accepted: 13 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Metabolic Reprogramming and Vulnerabilities in Cancer)
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PDF [845 KB, uploaded 16 August 2019]
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Abstract

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity. View Full-Text
Keywords: ROS; mitochondria; tumorigenesis; tumor microenvironment; stroma; tissue infiltrating lymphocytes; metabolism ROS; mitochondria; tumorigenesis; tumor microenvironment; stroma; tissue infiltrating lymphocytes; metabolism
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Weinberg, F.; Ramnath, N.; Nagrath, D. Reactive Oxygen Species in the Tumor Microenvironment: An Overview. Cancers 2019, 11, 1191.

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