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Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

1,2,†, 1,2,†, 1,2, 1,2 and 1,2,3,*
1
Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea
2
Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea
3
Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(5), 640; https://doi.org/10.3390/cancers11050640
Received: 8 April 2019 / Revised: 29 April 2019 / Accepted: 2 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Cancer Nanomedicine)
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PDF [2966 KB, uploaded 8 May 2019]
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Abstract

Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands. Such ligands can bind specific receptors on the surface of target cells. Furthermore, biological ligands can facilitate uptake of modified NPs, which is referred to as ‘active targeting’ of NPs. In this review, we discuss recent applications of biological ligands including proteins, polysaccharides, aptamers, peptides, and small molecules for NP-mediated drug delivery. We prioritized studies that have demonstrated targeting in animals over in vitro studies. We expect that this review will assist biomedical researchers working with NPs for drug delivery and imaging. View Full-Text
Keywords: nanoparticle; drug delivery; ligand; active targeting; tumor targeting; biodistribution nanoparticle; drug delivery; ligand; active targeting; tumor targeting; biodistribution
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Yoo, J.; Park, C.; Yi, G.; Lee, D.; Koo, H. Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems. Cancers 2019, 11, 640.

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