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A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

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Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
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MEDFUTURE-Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
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Biozoon GmbH, D-27572 Bremerhaven, Germany
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Department of Surgery, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 40015 Cluj-Napoca, Romania
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Department of Surgical Oncology and Gynecological Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 40015 Cluj-Napoca, Romania
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Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
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Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland
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Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria
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Central European Institute of Technology, Masaryk University, 601 77 Brno, Czech Republic
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Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, 601 77 Brno, Czech Republic
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5th Surgical Department, Municipal Hospital, 400139, Cluj-Napoca, Romania
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Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
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Department of Functional Genomics and Experimental Pathology, The Oncology Institute Prof. Dr. Ion Chiricuta, Republicii 34 Street, 400015 Cluj-Napoca, Romania
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Author to whom correspondence should be addressed.
Co-first authors of this study.
Cancers 2019, 11(10), 1618; https://doi.org/10.3390/cancers11101618
Received: 19 September 2019 / Revised: 13 October 2019 / Accepted: 16 October 2019 / Published: 22 October 2019
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes. Numerous studies focused on both the homeostatic and the pathologic conduct of MAPK signaling; however, there is still much to be deciphered in terms of regulation and action models in both preclinical and clinical research. MAPK has implications in the response to cancer therapy, particularly the activation of the compensatory pathways in response to experimental MAPK inhibition. The present paper discusses new insights into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways. Unfortunately, most MAPK inhibitors trigger resistance due to the activation of compensatory feed-back loops in tumor cells and tumor microenvironment components. Therefore, novel combinatorial therapies have to be implemented for cancer management in order to restrict the possibility of alternative pathway activation, as a perspective for developing novel therapies based on integration in translational studies. View Full-Text
Keywords: cancer; MAPK; molecular mechanisms; drug resistance cancer; MAPK; molecular mechanisms; drug resistance
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MDPI and ACS Style

Braicu, C.; Buse, M.; Busuioc, C.; Drula, R.; Gulei, D.; Raduly, L.; Rusu, A.; Irimie, A.; Atanasov, A.G.; Slaby, O.; Ionescu, C.; Berindan-Neagoe, I. A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer. Cancers 2019, 11, 1618. https://doi.org/10.3390/cancers11101618

AMA Style

Braicu C, Buse M, Busuioc C, Drula R, Gulei D, Raduly L, Rusu A, Irimie A, Atanasov AG, Slaby O, Ionescu C, Berindan-Neagoe I. A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer. Cancers. 2019; 11(10):1618. https://doi.org/10.3390/cancers11101618

Chicago/Turabian Style

Braicu, Cornelia, Mihail Buse, Constantin Busuioc, Rares Drula, Diana Gulei, Lajos Raduly, Alexandru Rusu, Alexandru Irimie, Atanas G. Atanasov, Ondrej Slaby, Calin Ionescu, and Ioana Berindan-Neagoe. 2019. "A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer" Cancers 11, no. 10: 1618. https://doi.org/10.3390/cancers11101618

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