Nutrients, Volume 11, Issue 4 (April 2019) – 233 articles
Cover Story (view full-size image): An increasing amount of evidence points towards migraine being a response to cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic diet (KD), a diet mimicking fasting that leads to the elevation of ketone bodies (KBs), is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraine. KBs are an alternative fuel source for the brain and are hence likely able to circumvent some of the abnormalities in glucose metabolism and transport found in migraine. As signalling molecules, they have the potential to positively influence other pathways commonly believed to be part of migraine pathophysiology. This review will describe the mechanisms by which the presence of KBs, D-BHB in particular, could influence those migraine pathophysiological mechanisms. View this paper.
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