- Article
Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats
- Salinee Naewla,
- Apiwat Sirichoat,
- Wanassanan Pannangrong,
- Pornthip Chaisawang,
- Peter Wigmore and
- Jariya Umka Welbat
Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts...

