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Nutrients, Volume 11, Issue 4

April 2019 - 233 articles

Cover Story: An increasing amount of evidence points towards migraine being a response to cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic diet (KD), a diet mimicking fasting that leads to the elevation of ketone bodies (KBs), is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraine. KBs are an alternative fuel source for the brain and are hence likely able to circumvent some of the abnormalities in glucose metabolism and transport found in migraine. As signalling molecules, they have the potential to positively influence other pathways commonly believed to be part of migraine pathophysiology. This review will describe the mechanisms by which the presence of KBs, D-BHB in particular, could influence those migraine pathophysiological mechanisms. View this paper.
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Articles (233)

  • Article
  • Open Access
50 Citations
7,019 Views
14 Pages

Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats

  • Salinee Naewla,
  • Apiwat Sirichoat,
  • Wanassanan Pannangrong,
  • Pornthip Chaisawang,
  • Peter Wigmore and
  • Jariya Umka Welbat

25 April 2019

Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts...

  • Article
  • Open Access
33 Citations
9,217 Views
13 Pages

25 April 2019

We aimed to explore the effects of caffeinated gel ingestion on neuromuscular performance in resistance-trained men. The participants (n = 17; mean ± standard deviation (SD): age 23 ± 2 years, height 183 ± 5 cm, body mass 83 &plu...

  • Feature Paper
  • Article
  • Open Access
27 Citations
12,707 Views
12 Pages

Association of Full Breastfeeding Duration with Postpartum Weight Retention in a Cohort of Predominantly Breastfeeding Women

  • Muna J. Tahir,
  • Jacob L. Haapala,
  • Laurie P. Foster,
  • Katy M. Duncan,
  • April M. Teague,
  • Elyse O. Kharbanda,
  • Patricia M. McGovern,
  • Kara M. Whitaker,
  • Kathleen M. Rasmussen and
  • David A. Fields
  • + 3 authors

25 April 2019

Full breastfeeding (FBF) is promoted as effective for losing pregnancy weight during the postpartum period. This study evaluated whether longer FBF is associated with lower maternal postpartum weight retention (PPWR) as compared to a shorter FBF dura...

  • Article
  • Open Access
20 Citations
6,323 Views
14 Pages

Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro

  • Erika Cione,
  • Pierluigi Plastina,
  • Attilio Pingitore,
  • Mariarita Perri,
  • Maria Cristina Caroleo,
  • Alessia Fazio,
  • Renger Witkamp and
  • Jocelijn Meijerink

24 April 2019

In this study, two capsaicin analogues, N-eicosapentaenoyl vanillylamine (EPVA) and N-docosahexaenoyl vanillylamine (DHVA), were enzymatically synthesized from their corresponding n-3 long chain polyunsaturated fatty acids eicosapentaenoic acid (EPA)...

  • Article
  • Open Access
2 Citations
4,691 Views
12 Pages

Mean Dietary Salt Intake in Vanuatu: A Population Survey of 755 Participants on Efate Island

  • Katherine Paterson,
  • Nerida Hinge,
  • Emalie Sparks,
  • Kathy Trieu,
  • Joseph Alvin Santos,
  • Len Tarivonda,
  • Wendy Snowdon,
  • Jacqui Webster and
  • Claire Johnson

24 April 2019

Non-communicable diseases are responsible for 63% of global deaths, with a higher burden in low- and middle-income countries. Hypertension is the leading cause of cardiovascular-disease-related deaths worldwide, and approximately 1.7 million deaths a...

  • Article
  • Open Access
37 Citations
6,093 Views
19 Pages

24 April 2019

Hepatic steatosis, an early stage of non-alcoholic fatty liver disease, is commonly present in obesity and type 2 diabetes, and is associated with reduced hepatic omega-3 polyunsaturated fatty acid (n3-PUFA) status that impacts on the anti-inflammato...

  • Article
  • Open Access
15 Citations
5,206 Views
10 Pages

24 April 2019

Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded,...

  • Article
  • Open Access
12 Citations
9,352 Views
9 Pages

Biotin Is Required for the Zinc Homeostasis in the Skin

  • Youichi Ogawa,
  • Manao Kinoshita,
  • Takuya Sato,
  • Shinji Shimada and
  • Tatsuyoshi Kawamura

24 April 2019

Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previously shown...

  • Article
  • Open Access
44 Citations
7,985 Views
14 Pages

Differences in Maternal Immunoglobulins within Mother’s Own Breast Milk and Donor Breast Milk and across Digestion in Preterm Infants

  • Veronique Demers-Mathieu,
  • Robert K. Huston,
  • Andi M. Markell,
  • Elizabeth A. McCulley,
  • Rachel L. Martin,
  • Melinda Spooner and
  • David C. Dallas

24 April 2019

Maternal antibody transfer to the newborn provides essential support for the infant’s naïve immune system. Preterm infants normally receive maternal antibodies through mother’s own breast milk (MBM) or, when mothers are unable to pro...

  • Article
  • Open Access
15 Citations
4,850 Views
18 Pages

24 April 2019

Qualified health claims (QHC) describe diet–disease relationships and summarize the quality and strength of evidence for a claim. Companies assert that QHCs increase sales and take legal action to ensure claims reflect their interests. Yet, there is...

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Nutrients - ISSN 2072-6643