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Serum Concentration of Genistein, Luteolin and Colorectal Cancer Prognosis
Article

Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer

1
Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung and Chang Gung University, College of Medicine, Keelung 204, Taiwan
2
Department of Nutrition, Chang Gung Memorial Hospital, Keelung and Chang Gung University, College of Medicine, Keelung 204, Taiwan
3
Division of Colorectal Surgery, Chang Gung Memorial Hospital, Keelung and Chang Gung University, College of Medicine, Keelung 204, Taiwan
4
Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou and Chang Gung University, College of Medicine, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 898; https://doi.org/10.3390/nu11040898
Received: 1 April 2019 / Revised: 16 April 2019 / Accepted: 18 April 2019 / Published: 21 April 2019
(This article belongs to the Special Issue Nutrition and Cancer: From Prevention to Survivorship)
Limited studies have assessed the associations of pretreatment serum glutamine level with clinicopathological characteristics and prognosis of colorectal cancer (CRC) patients. This study focuses on clarifying the clinical significance of baseline serum glutamine level in CRC patients. We retrospectively examine 123 patients with newly diagnosed CRC between 2009 and 2011. The associations of pretreatment serum glutamine level with clinicopathological characteristics, proinflammatory cytokines, overall survival (OS), and progression-free survival (PFS) were analyzed. We executed univariate and multivariate analyses to assess the associations between serum glutamine level and clinicopathological variables able to predict survival. Low glutamine levels were associated with older age, advanced stage, decreased albumin levels, elevated carcinoembryonic antigen levels, higher C-reactive protein levels, higher modified Glasgow prognostic scores, and higher proinflammatory cytokine levels. Furthermore, patients with low glutamine levels had poorer OS and PFS than those with high glutamine levels (p < 0.001 for both). In multivariate analysis, pretreatment glutamine level independently predicted OS (p = 0.016) and PFS (p = 0.037) in CRC patients. Pretreatment serum glutamine level constitutes an independent prognostic marker to predict survival and progression in CRC patients. View Full-Text
Keywords: colorectal cancer; serum glutamine level; survival; progression; inflammation colorectal cancer; serum glutamine level; survival; progression; inflammation
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MDPI and ACS Style

Ling, H.H.; Pan, Y.-P.; Fan, C.-W.; Tseng, W.-K.; Huang, J.-S.; Wu, T.-H.; Chou, W.-C.; Wang, C.-H.; Yeh, K.-Y.; Chang, P.-H. Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer. Nutrients 2019, 11, 898. https://doi.org/10.3390/nu11040898

AMA Style

Ling HH, Pan Y-P, Fan C-W, Tseng W-K, Huang J-S, Wu T-H, Chou W-C, Wang C-H, Yeh K-Y, Chang P-H. Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer. Nutrients. 2019; 11(4):898. https://doi.org/10.3390/nu11040898

Chicago/Turabian Style

Ling, Hang H.; Pan, Yi-Ping; Fan, Chung-Wei; Tseng, Wen-Ko; Huang, Jen-Seng; Wu, Tsung-Han; Chou, Wen-Chi; Wang, Cheng-Hsu; Yeh, Kun-Yun; Chang, Pei-Hung. 2019. "Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer" Nutrients 11, no. 4: 898. https://doi.org/10.3390/nu11040898

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