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Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults

1
College of Health Sciences, University of Kentucky, Lexington, KY 40536, USA
2
Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
3
Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 930; https://doi.org/10.3390/nu11040930
Received: 29 March 2019 / Revised: 18 April 2019 / Accepted: 22 April 2019 / Published: 25 April 2019
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Abstract

Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60–80 years with a BMI ranging from 18.5–34.9 and vitamin D status of ≤32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D3) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks and treadmill aerobic training during week 13. Gastrocnemius IMCL and EMCL were measured with magnetic resonance spectroscopy (MRS) and MRI. Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics. Group differences in IMCL were observed when controlling for baseline IMCL (p = 0.049). DAT was the only group to reduce IMCL from baseline, while a mean increase was observed in all other groups combined (p = 0.008). IMCL reduction and the corresponding increase in rVO2 at study end (p = 0.011) were unique to DAT. Vitamin D, when combined with exercise, may potentiate the metabolic benefits of exercise by reducing IMCL and increasing tissue-level VO2 in healthy, older adults. View Full-Text
Keywords: skeletal muscle; IMCL; sarcopenia; metabolic function; vitamin D skeletal muscle; IMCL; sarcopenia; metabolic function; vitamin D
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Thomas, D.T.; Schnell, D.M.; Redzic, M.; Zhao, M.; Abraha, H.; Jones, D.; Brim, H.; Yu, G. Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults. Nutrients 2019, 11, 930.

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