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Article

Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E

1
Department of Biochemistry, Federal University of Rio Grande do Norte, 59078-970 Natal-RN, Brazil
2
Department of Nutrition, Federal University of Rio Grande do Norte, 59078-970 Natal-RN, Brazil
3
Department of Pharmacy, Federal University of Rio Grande do Norte, 59012-570 Natal-RN, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 900; https://doi.org/10.3390/nu11040900
Received: 26 February 2019 / Revised: 5 April 2019 / Accepted: 9 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Human Milk and Lactation)
Background: Vitamin E supplementation might represent an efficient strategy to increase the vitamin E content in milk. The present study aimed to evaluate the impact of supplementation with 800 IU RRR-alpha-tocopherol on the alpha-tocopherol content of milk and the factors associated with the increase in vitamin E. Methods: Randomized clinical trial with 79 lactating women from Brazil, who were assigned to the control group, or to the supplemented group (800 IU of RRR-alpha-tocopherol). Milk and serum were collected between 30 and 90 days after delivery (collection 1), and on the next day (collection 2). Alpha-tocopherol was analyzed using high-performance liquid chromatography. Results: In the supplemented group, the alpha-tocopherol content in serum and milk increased after supplementation (p < 0.001). In the multivariate analysis, only alpha-tocopherol in milk (collection 1) was associated with the level of this vitamin in milk after supplementation (β = 0.927, p < 0.001), and binary logistic regression showed that the dietary intake was the only determinant for the greater effect of supplementation in milk. Conclusion: The pre-existing vitamin level in milk and diet are determinants for the efficacy of supplementation in milk, suggesting that in populations with vitamin E deficiency, high-dose supplementation can be used to restore its level in milk. View Full-Text
Keywords: clinical trial; lactation; infants; breastfeeding; lactating women clinical trial; lactation; infants; breastfeeding; lactating women
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MDPI and ACS Style

de Sousa Rebouças, A.; Costa Lemos da Silva, A.G.; Freitas de Oliveira, A.; Thalia Pereira da Silva, L.; de Freitas Felgueiras, V.; Cruz, M.S.; Silbiger, V.N.; da Silva Ribeiro, K.D.; Dimenstein, R. Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E. Nutrients 2019, 11, 900. https://doi.org/10.3390/nu11040900

AMA Style

de Sousa Rebouças A, Costa Lemos da Silva AG, Freitas de Oliveira A, Thalia Pereira da Silva L, de Freitas Felgueiras V, Cruz MS, Silbiger VN, da Silva Ribeiro KD, Dimenstein R. Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E. Nutrients. 2019; 11(4):900. https://doi.org/10.3390/nu11040900

Chicago/Turabian Style

de Sousa Rebouças, Amanda, Ana G. Costa Lemos da Silva, Amanda Freitas de Oliveira, Lorena Thalia Pereira da Silva, Vanessa de Freitas Felgueiras, Marina S. Cruz, Vivian N. Silbiger, Karla D. da Silva Ribeiro, and Roberto Dimenstein. 2019. "Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E" Nutrients 11, no. 4: 900. https://doi.org/10.3390/nu11040900

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