Next Article in Journal
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status
Previous Article in Journal
Reproducibility and Validity of a Short Food Frequency Questionnaire for Dietary Assessment in Children Aged 7–9 Years in Spain
Open AccessArticle

Antiperiodontitis Effects of Magnolia biondii Extract on Ligature-Induced Periodontitis in Rats

1
Department of Biotechnology, Chonnam National University, Yeosu 59626, Korea
2
Nutrapharm Tech, Jungwon-gu, Seongnam, Gyunggi 13201, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 934; https://doi.org/10.3390/nu11040934
Received: 9 April 2019 / Revised: 20 April 2019 / Accepted: 24 April 2019 / Published: 25 April 2019
Over the past decades, periodontitis has become a rising health problem and caused various diseases. In the many studies shows that some extracts and compound to the prevention and treatment of periodontitis. This study focuses on the effects of inhibition of gingival damage and alveolar bone loss. The aim of this study was to evaluate the protective effects of Magnolia biondii extract (MBE) against ligature-induced periodontitis in rats. A ligature was placed around the molar teeth for 8 weeks, and MBE was administered for 8 weeks. Gingival tissue damage and alveolar bone loss were measured by microcomputed tomography (CT) analysis and histopathological examination. Serum Interluekin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), cyclooxygenases-2 (COX-2), and receptor activator of nuclear factor–κB ligand (RANKL) levels were investigated using commercial kits to confirm the antiperiodontitis effects of MBE. We confirmed that ligature-induced periodontitis resulted in gingival tissue damage and alveolar bone loss. However, treatment for 8 weeks with MBE protected from periodontal tissue damage and downregulated serum inflammatory cytokine factors and RANKL levels. These results suggest that MBE exerts antiperiodontitis effects by inhibiting gingival tissue destruction and alveolar bone loss through regulation of anti-inflammatory cytokines in periodontitis-induced rats. View Full-Text
Keywords: antiperiodontitis; inflammatory cytokine; alveolar bone resorption; Magnolia biondii; periodontal tissue antiperiodontitis; inflammatory cytokine; alveolar bone resorption; Magnolia biondii; periodontal tissue
Show Figures

Figure 1

MDPI and ACS Style

Lee, H.J.; Lee, D.-R.; Choi, B.-K.; Yang, S.H. Antiperiodontitis Effects of Magnolia biondii Extract on Ligature-Induced Periodontitis in Rats. Nutrients 2019, 11, 934.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop