Table of Contents
Mar. Drugs, Volume 17, Issue 11 (November 2019) – 53 articles
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Cover Story (view full-size image) The prevalence of inflammatory bowel diseases (IBD) including ulcerative colitis and Crohen’s [...] Read more. The prevalence of inflammatory bowel diseases (IBD) including ulcerative colitis and Crohen’s disease has been increasing worldwide. In our search for intestinal anti-inflammatory compounds from marine sponges, bioactive phylloketal derivatives have been successfully isolated from the genus of Phyllospongia. Anti-inflammatory actions of deacetylphylloketal (
1) and phyllohemiketal A ( 2) were evaluated using a co-culture system consisted of human epithelial Caco-2 and PMA-differentiated THP-1 macrophage cells, which resembles human intestinal environment. The treatment of 1 or 2 significantly suppressed the expression of LPS-induced proinflammatory cytokines and proteins, as well as promoted the nuclear translocation of Nrf2 and the expression increase of HO-1. View this paper.