Next Article in Journal
Hybrid Polyketides from a Hydractinia-Associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin
Next Article in Special Issue
Novel Microcystins from Planktothrix prolifica NIVA-CYA 544 Identified by LC-MS/MS, Functional Group Derivatization and 15N-labeling
Previous Article in Journal
Biotechnological Applications of Scyphomedusae
Previous Article in Special Issue
Bioactive Diketopiperazines and Nucleoside Derivatives from a Sponge-Derived Streptomyces Species
Open AccessArticle

Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai

by Hong-Lei Li 1,2,3, Xiao-Ming Li 1,2,3, Sui-Qun Yang 1,2,3, Ling-Hong Meng 1,2,3, Xin Li 1,2,3 and Bin-Gui Wang 1,2,3,*
1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China
3
Center for Ocean Mega-Science, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 605; https://doi.org/10.3390/md17110605
Received: 27 September 2019 / Revised: 22 October 2019 / Accepted: 23 October 2019 / Published: 24 October 2019
Three new prenylated phenol derivatives, terreprenphenols A–C (13), along with four known related compounds (47), were isolated from Aspergillus terreus EN-539, an endophytic fungus obtained from the marine red alga Laurencia okamurai. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, and optical rotation (OR). The corresponding relationship between absolute configuration and optical rotation for known compounds anodendroic acid (4) and asperterreusine C (5) was ambiguous in literature, and their absolute configurations were therefore discussed and confirmed for the first time by time-dependent density functional (TDDFT) ECD and OR calculations. Compounds 17 inhibited some common aquatic bacteria with MIC values ranging from 2 to 64 μg/mL. View Full-Text
Keywords: Laurencia okamurai; Aspergillus terreus; endophytic fungus; prenylated phenol; benzofuran; antibacterial activity Laurencia okamurai; Aspergillus terreus; endophytic fungus; prenylated phenol; benzofuran; antibacterial activity
Show Figures

Figure 1

MDPI and ACS Style

Li, H.-L.; Li, X.-M.; Yang, S.-Q.; Meng, L.-H.; Li, X.; Wang, B.-G. Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai. Mar. Drugs 2019, 17, 605.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop