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Open AccessArticle

Dechdigliotoxins A–C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China
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Mar. Drugs 2019, 17(11), 596; https://doi.org/10.3390/md17110596
Received: 3 October 2019 / Revised: 18 October 2019 / Accepted: 21 October 2019 / Published: 23 October 2019
Dechdigliotoxins A–C (1–3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations were unambiguously determined through quantum chemical calculations, as well as DP4+ probability simulations. The proposed biosynthetic pathway suggested 1–3 were generated from unusual L-Phe and D-Ser. All the isolates were evaluated for their cytotoxicity against four tumor cell lines. View Full-Text
Keywords: dechdigliotoxins; disulfide-bridged; dimer; deep-sea derived fungus; quantum chemical calculations; cytotoxicity dechdigliotoxins; disulfide-bridged; dimer; deep-sea derived fungus; quantum chemical calculations; cytotoxicity
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MDPI and ACS Style

Liu, Z.; Fan, Z.; Sun, Z.; Liu, H.; Zhang, W. Dechdigliotoxins A–C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii. Mar. Drugs 2019, 17, 596.

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