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Open AccessArticle

Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia
2
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 616; https://doi.org/10.3390/md17110616
Received: 10 October 2019 / Revised: 23 October 2019 / Accepted: 25 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Marine Glycoconjugates: Trends and Perspectives)
Ten new diterpene glycosides virescenosides Z9-Z18 (110) together with three known analogues (1113) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 1518 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated. View Full-Text
Keywords: Acremonium striatisporum; secondary metabolites; marine fungi; diterpene glycosides; urease activity Acremonium striatisporum; secondary metabolites; marine fungi; diterpene glycosides; urease activity
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Zhuravleva, O.I.; Antonov, A.S.; Oleinikova, G.K.; Khudyakova, Y.V.; Popov, R.S.; Denisenko, V.A.; Pislyagin, E.A.; Chingizova, E.A.; Afiyatullov, S.S. Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401. Mar. Drugs 2019, 17, 616.

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