Next Article in Journal
Effect of Ishophloroglucin A, A Component of Ishige okamurae, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice
Next Article in Special Issue
Dietary Supplementation with the Red Seaweed Porphyra umbilicalis Protects against DNA Damage and Pre-Malignant Dysplastic Skin Lesions in HPV-Transgenic Mice
Previous Article in Journal
Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B
Previous Article in Special Issue
Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava Attenuates Tubular Epithelial Cell (TCMK-1) Death in Hypoxia/Reoxygenation Injury
Open AccessReview

Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer’s Disease

1
Applied Environmental and Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Eastern Cape, Alice 5700, South Africa
2
SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Eastern Cape, Alice 5700, South Africa
3
Nutrition and Toxicology Division, Food Technology Department, Federal Institute of Industrial Research, Oshodi, Lagos PMB 21023, Nigeria
4
Discipline of Microbiology, School of Life Sciences, College of Agricultural, Engineering and Science, University of Kwazulu-Natal, Durban 4001, South Africa
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 609; https://doi.org/10.3390/md17110609
Received: 20 September 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 25 October 2019
Alzheimer’s disease (AD) is a neurological condition that affects mostly aged individuals. Evidence suggests that pathological mechanisms involved in the development of AD are associated with cholinergic deficit, glutamate excitotoxicity, beta-amyloid aggregation, tau phosphorylation, neuro-inflammation, and oxidative damage to neurons. Currently there is no cure for AD; however, synthetic therapies have been developed to effectively manage some of the symptoms at the early stage of the disease. Natural products from plants and marine organisms have been identified as important sources of bioactive compounds with neuroprotective potentials and less adverse effects compared to synthetic agents. Seaweeds contain several kinds of secondary metabolites such as phlorotannins, carotenoids, sterols, fucoidans, and poly unsaturated fatty acids. However, their neuroprotective effects and mechanisms of action have not been fully explored. This review discusses recent investigations and/or updates on interactions of bioactive compounds from seaweeds with biomarkers involved in the pathogenesis of AD using reports in electronic databases such as Web of science, Scopus, PubMed, Science direct, Scifinder, Taylor and Francis, Wiley, Springer, and Google scholar between 2015 and 2019. Phlorotannins, fucoidans, sterols, and carotenoids showed strong neuroprotective potentials in different experimental models. However, there are no data from human studies and/or clinical trials. View Full-Text
Keywords: Alzheimer’s disease; seaweeds; cholinesterases; beta-secretase; beta-amyloid aggregation; neuroprotection Alzheimer’s disease; seaweeds; cholinesterases; beta-secretase; beta-amyloid aggregation; neuroprotection
Show Figures

Figure 1

MDPI and ACS Style

Olasehinde, T.A.; Olaniran, A.O.; Okoh, A.I. Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer’s Disease. Mar. Drugs 2019, 17, 609.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop