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Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia
2
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia
3
Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
4
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 647; https://doi.org/10.3390/md17110647
Received: 25 October 2019 / Revised: 12 November 2019 / Accepted: 14 November 2019 / Published: 18 November 2019
Six new carotane sesquiterpenoids piltunines A–F (16) together with known compounds (79) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 17 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined. View Full-Text
Keywords: Penicillium piltunense; secondary metabolites; carotane sesquiterpenoids; cytotoxic activity Penicillium piltunense; secondary metabolites; carotane sesquiterpenoids; cytotoxic activity
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Afiyatullov, S.S.; Zhuravleva, O.I.; Antonov, A.S.; Leshchenko, E.V.; Pivkin, M.V.; Khudyakova, Y.V.; Denisenko, V.A.; Pislyagin, E.A.; Kim, N.Y.; Berdyshev, D.V.; Amsberg, G.; Dyshlovoy, S.A. Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668. Mar. Drugs 2019, 17, 647.

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