Next Article in Journal
Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction
Previous Article in Journal
Mycosporine-Like Amino Acids: Making the Foundation for Organic Personalised Sunscreens
Previous Article in Special Issue
Testing the Neuroprotective Properties of PCSO-524® Using a Neuronal Cell Cycle Suppression Assay
Open AccessArticle

Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis

Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 639; https://doi.org/10.3390/md17110639
Received: 30 October 2019 / Revised: 7 November 2019 / Accepted: 8 November 2019 / Published: 13 November 2019
Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its neuroprotection is poorly understood. Here, we employed system pharmacology and in silico analysis to elucidate the underlying mechanism of neuropharmacological action of fucosterol against neurodegenerative disorders (NDD). Network pharmacology revealed that fucosterol targets signaling molecules, receptors, enzymes, transporters, transcription factors, cytoskeletal, and various other proteins of cellular pathways, including tumor necrosis factor (TNF), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), neurotrophin, and toll-like receptor (TLR) signaling, which are intimately associated with neuronal survival, immune response, and inflammation. Moreover, the molecular simulation study further verified that fucosterol exhibited a significant binding affinity to some of the vital targets, including liver X-receptor-beta (LXR-), glucocorticoid receptor (GR), tropomyosin receptor kinase B (TrkB), toll-like receptor 2/4 (TLR2/4), and β -secretase (BACE1), which are the crucial regulators of molecular and cellular processes associated with NDD. Together, the present system pharmacology and in silico findings demonstrate that fucosterol might play a significant role in modulating NDD-pathobiology, supporting its therapeutic application for the prevention and treatment of NDD. View Full-Text
Keywords: Alzheimer’s disease; fucosterol; molecular simulation; network pharmacology; neurodegeneration; Parkinson’s disease Alzheimer’s disease; fucosterol; molecular simulation; network pharmacology; neurodegeneration; Parkinson’s disease
Show Figures

Graphical abstract

MDPI and ACS Style

Hannan, M.A.; Dash, R.; Sohag, A.A.M.; Moon, I.S. Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis. Mar. Drugs 2019, 17, 639. https://doi.org/10.3390/md17110639

AMA Style

Hannan MA, Dash R, Sohag AAM, Moon IS. Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis. Marine Drugs. 2019; 17(11):639. https://doi.org/10.3390/md17110639

Chicago/Turabian Style

Hannan, Md. A.; Dash, Raju; Sohag, Abdullah A.M.; Moon, Il S. 2019. "Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis" Mar. Drugs 17, no. 11: 639. https://doi.org/10.3390/md17110639

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop