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Open AccessArticle

Anti-Obesity Effect of Diphlorethohydroxycarmalol Isolated from Brown Alga Ishige okamurae in High-Fat Diet-Induced Obese Mice

1
Department of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Korea
2
Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea
3
Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Korea
4
Department of Applied Research, National Marine Biodiversity Institute of Korea, Seochun 33662, Korea
5
Research Group of Food Processing, Korea Food Research Institute, Wanju 55365, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(11), 637; https://doi.org/10.3390/md17110637
Received: 20 October 2019 / Revised: 5 November 2019 / Accepted: 8 November 2019 / Published: 10 November 2019
(This article belongs to the Collection Marine Drugs in the Management of Metabolic Diseases)
Diphlorethohydroxycarmalol (DPHC) is one of the most abundant bioactive compounds in Ishige okamurae. The previous study suggested that DPHC possesses strong in vitro anti-obesity activity in 3T3-L1 cells. However, the in vivo anti-obesity effect of DPHC has not been determined. The current study explored the effect of DPHC on high-fat diet (HFD)-induced obesity in C57BL/6J mice. The results indicated that oral administration of DPHC (25 and 50 mg/kg/day for six weeks) significantly and dose-dependently reduced HFD-induced adiposity and body weight gain. DPHC not only decreased the levels of triglyceride, low-density lipoprotein cholesterol, leptin, and aspartate transaminase but also increased the level of high-density lipoprotein cholesterol in the serum of HFD mice. In addition, DPHC significantly reduced hepatic lipid accumulation by reduction of expression levels of the critical enzymes for lipogenesis including SREBP-1c, FABP4, and FAS. Furthermore, DPHC remarkably reduced the adipocyte size, as well as decreased the expression levels of key adipogenic-specific proteins and lipogenic enzymes including PPARγ, C/EBPα, SREBP-1c, FABP4, and FAS, which regulate the lipid metabolism in the epididymal adipose tissue (EAT). Further studies demonstrated that DPHC significantly stimulated the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in both liver and EAT. These results demonstrated that DPHC effectively prevented HFD-induced obesity and suggested that DPHC could be used as a potential therapeutic agent for attenuating obesity and obesity-related diseases. View Full-Text
Keywords: high-fat diet mice; Ishige okamurae; diphlorethohydroxycarmalol (DPHC); anti-obesity effect high-fat diet mice; Ishige okamurae; diphlorethohydroxycarmalol (DPHC); anti-obesity effect
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Ding, Y.; Wang, L.; Im, S.; Hwang, O.; Kim, H.-S.; Kang, M.-C.; Lee, S.-H. Anti-Obesity Effect of Diphlorethohydroxycarmalol Isolated from Brown Alga Ishige okamurae in High-Fat Diet-Induced Obese Mice. Mar. Drugs 2019, 17, 637.

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