Table of Contents
Molecules, Volume 22, Issue 8 (August 2017) – 149 articles
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Cover Story (view full-size image) Enzymatically synthesized LacNAc tetrasaccharides were conjugated to BSA protein scaffolds by [...] Read more. Enzymatically synthesized LacNAc tetrasaccharides were conjugated to BSA protein scaffolds by squarate linker chemistry. Resulting multivalent neo-glycoproteins were further studied for specific binding of the tumor-associated human galectin 3 (Gal-3) and its truncated counterpart Gal-3∆. We observed a significantly increased affinity of Gal-3∆ to neo-glycoproteins presenting LacNAc type 1 repeating units. This is the first evidence for differences in glycan selectivity of Gal-3∆ and Gal-3 and may be further utilized for tracing Gal-3∆ during tumor progression and therapy. View this paper