Special Issue "Sulfonamides"
Deadline for manuscript submissions: closed (1 March 2017)
Prof. Dr. Claudiu T. Supuran
Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino (Florence) 50019, Italy
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Interests: drug design; metalloenzymes; carbonic anhydrases, anticancer agents; antiinfectives; sulfonamides; coumarins
The primary sulfonamide moiety is present in many clinically used drugs, such as diuretics (furosemide, indapamide, chlorthalidone, thiazides), carbonic anhydrase (CA) inhibitors (CAIs, e.g., acetazolamide, dichlorophenamide, dorzolamide and brinzolamide, SLC-0111, an antitumor agent used in Phase I clinical trials); antiepileptics (zonisamide and sulthiame), the antipsychotic sulpiride, or the cycloxygenase 2 (COX2) inhibitors celecoxib, valdecoxib and palmecoxib. Recently, novel drugs incorporating this group were launched, for example, pazopanib. A large number of sulfonamides possessing various other pharmacologic applications were identified. Secondary and tertiary sulphonamides, as well as sulphonamide isosteres (sulfamides, sulfamates, etc.) are also present in a variety of biologically active compounds. This privileged structural motif will probably be utilized in other drugs in the future. This Special Issue of Molecules is dedicated to compounds from all these structural classes, which have the presence of primary, secondary or tertiary sufonamide moieties in common, as well as their isosteres.
Claudiu T. Supuran
Manuscript Submission Information
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- carbonic anhydrase inhibitor
- antiglaucoma drug
- antitumor agent
- cancer diagnostic tool
- cyclooxygenase 2 inhibitor
- receptor tyrosine kinase inhibitor