Plant Polyphenols as Potential Therapeutic Agents for Diabetes and Obesity
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 May 2017) | Viewed by 75855
Special Issue Editors
Interests: natural products chemistry; pharmacology; drug discovery; pharmacognosy
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug discovery; chirality
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Plant polyphenols are a diverse group of secondary metabolites predominantly synthesised through the shikimic acid and acetate/polyketide pathways. The common perception of polyphenols’ pharmacological effect is that they are mediated through a nonspecific interaction with proteins/enzymes and general antioxidant mechanisms. Numerous specific biological effects at sub-micromolar concentration are however common for many polyphenols. One of the distinct advantages of polyphenols is in their therapeutic potential for complex diseases like diabetes and obesity, where a one drug → one target → one disease approach offers limited efficacy. Through their multifunctional actions, plant polyphenols could ameliorate the various components of such diseases and offer a better outcome through the one drug → multitarget → one/multidisease principle. They could also work in a synergistic manner, with their crude mixtures often showing a higher activity than the isolated pure compounds (multidrug → multitarget → one/multidisease approach). Since both diabetes and obesity cases are now growing in the world with epidemic proportions, our desperate search for safer drugs from natural sources must continue. In this regard, polyphenols are best placed and this Special Issue is designed to scrutinise recent developments in the chemistry, pharmacology, and medical implications of polyphenols as potential therapeutics for diabetes and/or obesity. We are thus inviting colleagues to join us by making their valuable contributions to Molecules.
Prof. Solomon Habtemariam
Prof. Giovanni Lentini
Guest Editors
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Keywords
- plant polyphenols
- diabetes
- obesity
- mechanism of action
- drug discovery
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