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Molecules 2017, 22(8), 1378;

Cryochemical Synthesis of Polymorphous Nanostructures of a Steroid Neurohormone

Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow 119991, Russia
Department of Fundamental Science, Bauman Moscow Technical State University, Moscow 105005, Russian
Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119991, Russia
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS, Moscow 199071, Russian
Author to whom correspondence should be addressed.
Received: 17 July 2017 / Revised: 7 August 2017 / Accepted: 12 August 2017 / Published: 21 August 2017
(This article belongs to the Section Molecular Diversity)
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A new cryochemical strategy of producing nanoparticles and polymorphous nanostructures of drugs is used, which is based on the dynamic combination of high and low temperatures, gas and solid phases, and inert carrier gases. This technology is applied to the synthesis of nanoparticles of steroid neurohormone dehydroepiandrosterone (DHEA). We have optimized the conditions of synthesis of the new polymorphous DHEA structure, FVII. The molecules of DHEA in FVII structure are bound by hydrogen bonds via oxygen atoms. The grain size is 100 nm. It is shown that the yield and ratio of the resulting nanoforms of this hormone are determined by the nature and properties of the inert carrier gas. The highest yield and selectivity of FVII are observed when carbon dioxide is used as the carrier gas. In the case of helium, the FVII content decreases from 85 to 30% and other structures are formed. In experiments without carrier gas, nanoparticles are formed but no FVII is produced. The selectivity and the effect of carrier gas are considered on the basis of homogeneous and heterogeneous formation of nanoparticles and the relationship between particle selectivity and its activity. The synthesis of various polymorphous structures on the nanoscale is assumed to be the manifestation of the size effect in the synthesis of drugs. View Full-Text
Keywords: hormones; dehydroepiandrosterone (DHEA); new structures; polymorphism; nanoparticles; cryosynthesis hormones; dehydroepiandrosterone (DHEA); new structures; polymorphism; nanoparticles; cryosynthesis

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Morozov, Y.; Chistyakov, D.; Chernyshev, V.; Sergeev, G. Cryochemical Synthesis of Polymorphous Nanostructures of a Steroid Neurohormone. Molecules 2017, 22, 1378.

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