384 Results Found

This study applied Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) multispectral data and ZY1-02D hyperspectral data to map the structural distribution and hydrothermal alteration in the polymetallic ore district in southern Sh...

Background/Objectives: Accurate detection of all classes of genomic structural variants (SVs), including chromosomal rearrangements and copy number alterations (CNAs), is essential for the diagnosis and classification of hematologic neoplasms. Conven...

The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase (MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is involved in the regulation of a large variety of cellular processes. The ERK2, act...

This article aims to aid in exploring and forecasting hydrothermal minerals and gold deposits in Central Saudi Arabia (SA), with a focus on structural contexts. Remote sensing (RS) and satellite-based Bouguer gravity (SBG) data were integrated in ord...

Autism spectrum disorders (ASD) are neurodevelopmental diseases characterised by deficits in social communication, restricted interests, and repetitive behaviours. The growing body of evidence points to a role for cerebellar changes in ASD pathology....

Numerous alteration detection methods are designed based on image transformation algorithms and divergence of bi-temporal images. In the process of feature transformation, pseudo variant information caused by complex external factors will be highligh...

In this research, airborne geophysical and remote sensing datasets were integrated for gold potentiality mapping (GPM) over the Atalla area in Central Eastern Desert, Egypt. Utilizing aeromagnetic data, detailed structural complexity maps were constr...

Drill-core samples are a key component in mineral exploration campaigns, and their rapid and objective analysis is becoming increasingly important. Hyperspectral imaging of drill-cores is a non-destructive technique that allows for non-invasive and f...

This study produces alteration mineral maps based on WorldView-3 (WV-3) data and field shortwave-infrared (SWIR) spectroscopy. It is supported by conventional analytical methods such as X-ray diffraction, X-ray fluorescence, and electron probe X-ray...

This study developed a copper mineral prospectivity map for the Koldar massif, Kazakhstan, using an integrated approach combining geophysical and satellite methods. A strong spatialgenetic link was identified between faults and hydrothermal mineraliz...

The exploration of carbonate-hosted Pb-Zn mineralization is challenging due to the complex structural-geological settings and costly using geophysical and geochemical techniques. Hydrothermal alteration minerals and structural features are typically...

Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting both patients’ survival and well-being. Apart from aging, many cardiovascular risk factors may cause structural remodeling of the atrial myocardium lea...

The high-grade uranium deposits in the Xiemisitan area, northwestern China, are genetically associated with the faulting of felsic volcanic or sub-volcanic rocks. Ferric iron alteration indicates that oxidizing hydrothermal fluids percolated through...

The present work aims to map kaolin occurrences on the Kefalos peninsula, SW Kos Island, Greece, through the elaboration of ASTER satellite imagery. The island of Kos is located on the eastern edge of the South Aegean Active Volcanic Arc (SAAVA) and...

The tumour suppressor protein p53 plays a central role in safeguarding genomic integrity through the regulation of DNA repair, cell cycle arrest, and apoptosis. Mutations in TP53, particularly within its DNA-binding domain, are among the most frequen...

Plateau–orogenic belts host a substantial share of global gold resources, yet quantitative prospectivity mapping is challenged by complex mineralization and strongly heterogeneous, multi-scale datasets. Using the Mayoumu area (Tibet) as a repre...

Fusion and analysis of thematic information layers using machine learning algorithms provide an important step toward achieving accurate mineral potential maps in the reconnaissance stage of mineral exploration. This study developed the Neuro-Fuzzy-A...

The rapid mapping and characterization of specific porphyry vein types in geological samples represent a challenge for the mineral exploration and mining industry. In this paper, a methodology to integrate mineralogical and structural data extracted...

The gold mineralization located in the southern Eastern Desert of Egypt mostly occurs in characteristic geologic and structural settings. The gold-bearing quartz veins and the alteration zones are confined to the ductile shear zones between the highl...

Cardiovascular magnetic resonance (CMR) imaging is widely regarded as the gold-standard technique for myocardial tissue characterization, allowing for the detection of structural abnormalities such as myocardial fatty replacement, myocardial edema, m...

The prion-forming regions (PFRs) of yeast prion proteins are usually located at either the N- or C-terminus of a protein. In the Sup35 prion, the main prion structure contains 71 N-terminal residues. Here, we investigated the importance of the termin...

In this work, X-ray fluorescence (XRF) and Laser-induced breakdown spectroscopy (LIBS) analyses were applied to samples of quartz, montebrasite, and turquoise hydrothermal veins in the Argemela Tin Mine (Central Portugal). Montebrasite (LiAl(PO₄)(OH,...

The anoctamin (TMEM16) family of transmembrane protein consists of ten members in vertebrates, which act as Ca²⁺-dependent ion channels and/or Ca²⁺-dependent scramblases. ANO4 which is primarily expressed in the CNS and certain endocrine glands, has...

Mineral exploration works conducted in the Alto Guaporé Gold Province (AGGP), situated in the southwest region of the Amazon Craton in Brazil, faces the challenges of many gold provinces around the world, i.e., declines in the discoveries of n...

Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of pren...

The Koldar Massif in southeastern Kazakhstan is a geologically complex area with potential for porphyry copper and rare-metal mineralization. This study applies a multi-scale remote sensing approach to delineate hydrothermal alteration zones using me...

Forest degradation continues to increase globally, threatening biodiversity and the survival of species. In this context, identifying intact, old-growth forest stands is both urgent and vital to ensure their existence and multiple contributions to so...

The Pulang porphyry copper deposit (PCD), one of the main potential areas for copper resource exploration in China, exhibits typical porphyry alteration zoning. However, further investigation of the indicative significance of alteration minerals, add...

Pucheng district is a part of the Wuyi Mountain polymetallic metallogenic belt, which is constituted by Archean-Proterozoic metamorphic basements and Mesozoic volcanic-sedimentary covers. Uranium deposits are formed as volcanic-hosted and structural...

Intrinsically disordered regions (IDRs) of transcription factors play an important biological role in liquid condensate formation and gene regulation. It is thus desirable to investigate the druggability of IDRs and how small-molecule binders can alt...

Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes...

Human bone is a specialized tissue with unique material properties, providing mechanical support and resistance to the skeleton and simultaneously assuring capability of adaptation and remodelling. Knowing the properties of such a structure down to t...

Vip3 proteins are increasingly used in insect control in transgenic crops. To shed light on the structure of these proteins, we used the approach of the trypsin fragmentation of mutants altering the conformation of the Vip3Af protein. From an alanine...

Background: Quantitative magnetic resonance imaging (MRI) techniques such as T₂ mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean T₂ value...

Osteoarthritis is a chronic disease that often affects the canine stifle joint. Due to their biomechanical function, the menisci in the canine stifle play an important role in osteoarthritis. They compensate for the incongruence in the joint and dist...

Equinatoxin II (EqtII) and Fragaceatoxin C (FraC) are pore-forming toxins (PFTs) from the actinoporin family that have enhanced membrane affinity in the presence of sphingomyelin (SM) and phase coexistence in the membrane. However, little is known ab...

Multi-sensor satellite imagery data promote fast, cost-efficient regional geological mapping that constantly forms a criterion for successful gold exploration programs in harsh and inaccessible regions. The Barramiya–Mueilha sector in the Centr...

Deafness in vertebrates is associated with variants of hundreds of genes. Yet, many mutant genes causing rare forms of deafness remain to be discovered. A consanguineous Pakistani family segregating nonsyndromic deafness in two sibships were studied...

Sarcomas are rare malignant tumors of mesenchymal origin with a high misdiagnosis rate due to their heterogeneity and low incidence. Conventional diagnostic techniques, such as Fluorescence In Situ Hybridization (FISH) and Next-Generation Sequencing...

Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with WT mice, tau-KO mice display...

Background: Schizophrenia is a complex disorder characterized by disruptions in cognition, behavior, and emotions. Extensive research has uncovered alterations in a single modality (either the brain structure or function) in schizophrenia. However, t...

Multispectral remote sensing offers powerful capabilities for mineral exploration, particularly in regions with complex geological settings. This study investigates the mineralization potential of the Tidili region in Morocco, located between the Sou...

Plakophilin-2 (PKP2) is the most frequently mutated desmosomal gene in arrhythmogenic cardiomyopathy (ACM), a disease characterized by structural and electrical alterations predominantly affecting the right ventricular myocardium. Notably, ACM cases...

Much of today’s molecular science revolves around next-generation sequencing. Frequently, the first step in analyzing such data is aligning sequencing reads to a reference genome. This step is often taken for granted, but any analysis downstrea...

The Paleoproterozoic Aravalli Supergroup in northwest India hosts one of the oldest phosphorite deposits on Earth, located in the Jhamarkotra Formation, which was deposited after ca. 1762 Ma. Secondary enrichment is identified in the eastern region,...

The Qulong–Jiama polymetallic ore concentration area, located in the eastern segment of the Gangdese metallogenic belt, is one of China’s most significant copper resource production zones. With the growing demand for copper resources, thi...

Hyperspectral imaging is a powerful tool for mineral mapping and increasingly used in poorly-accessible areas. It only requires a limited amount of validation sample points, but can fail to discriminate spectrally-similar features. In this manuscript...

Structural microtubule associated protein Tau is found in high amount in axons and is involved in several neurodegenerative diseases. Although many studies have highlighted the toxicity of an excess of Tau in neurons, the in vivo understanding of the...

Egypt’s mineral resources are an effective means of raising the country’s income. Consequently, searching for deep subsurface ore deposits is essential. In this study, we map the subsurface structure and the occurrence of related gold-ore...

Geological mapping and mineral exploration programs in the High Arctic have been naturally hindered by its remoteness and hostile climate conditions. The Franklinian Basin in North Greenland has a unique potential for exploration of world-class zinc...