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690 Results Found

  • Article
  • Open Access
7 Citations
2,090 Views
10 Pages

Microbial Spectrum and Antibiotic Resistance in Patients Suffering from Penetrating Crohn’s Disease

  • Simon Kusan,
  • Güzin Surat,
  • Matthias Kelm,
  • Friedrich Anger,
  • Mia Kim,
  • Christoph-Thomas Germer,
  • Nicolas Schlegel and
  • Sven Flemming

26 July 2022

Intraabdominal abscess formation occurs in up to 30% of patients suffering from Crohn´s disease (CD). While international guidelines recommend a step-up approach with a combination of empiric antibiotic therapy and percutaneous drainage to dela...

  • Article
  • Open Access
4 Citations
2,127 Views
9 Pages

Disease- and Medication-Specific Differences of the Microbial Spectrum in Perianal Fistulizing Crohn’s Disease—Relevant Aspects for Antibiotic Therapy

  • Matthias Kelm,
  • Simon Kusan,
  • Güzin Surat,
  • Friedrich Anger,
  • Joachim Reibetanz,
  • Christoph-Thomas Germer,
  • Nicolas Schlegel and
  • Sven Flemming

Perianal fistulizing Crohn’s Disease (CD) with abscess formation represents an aggressive phenotype in Inflammatory Bowel Disease (IBD) with increased morbidity. Treatment is multidisciplinary and includes antibiotics, but knowledge about the m...

  • Review
  • Open Access
2 Citations
6,183 Views
29 Pages

The Effects of Fecal Microbial Transplantation on the Symptoms in Autism Spectrum Disorder, Gut Microbiota and Metabolites: A Scoping Review

  • Ignazio Maniscalco,
  • Piotr Bartochowski,
  • Vittoria Priori,
  • Sidonia Paula Iancau,
  • Michele De Francesco,
  • Marco Innamorati,
  • Natalia Jagodzinska,
  • Giancarlo Giupponi,
  • Luca Masucci and
  • Andreas Conca
  • + 1 author

The bilateral interaction between the brain and the gut has recently been on the spectrum of researchers’ interests, including complex neural, endocrinological, and immunological signaling pathways. The first case reports and clinical studies h...

  • Review
  • Open Access
2 Citations
6,718 Views
16 Pages

5 December 2024

In the United States, autism spectrum disorder (ASD) affects 1 in 33 children and is characterized by atypical social interactions, communication difficulties, and intense, restricted interests. Microbial dysbiosis in the gastrointestinal (GI) tract...

  • Article
  • Open Access
3 Citations
2,183 Views
21 Pages

Ardisia crenata Sims, an important ethnic medicine, is recorded in the Chinese Pharmacopoeia for treating laryngeal diseases and upper respiratory tract infections. This study aimed to evaluate the antimicrobial effect of extracts and potential antim...

  • Article
  • Open Access
1 Citations
988 Views
12 Pages

14 February 2025

Background/Objectives: Bronchial wash for microbiological cultivation and/or multiplex polymerase chain reaction (PCR) is often routinely performed during bronchoscopy independent of the indication for bronchoscopy. This study aimed to determine and...

  • Article
  • Open Access
1,297 Views
34 Pages

Metagenomic Characterization of Gut Microbiota in Children with Autism Spectrum Disorder: Microbial Signatures and Modulation by Anti-Inflammatory Diet and Probiotics

  • Marysol Valencia-Buitrago,
  • Rodrigo Dias Oliveira-Carvalho,
  • Valbert Cardoso,
  • Jessica Triviño-Valencia,
  • Luisa Matilde Salamanca-Duque,
  • Vanessa Martínez-Díaz,
  • Jovanny Zabaleta,
  • Narmer Fernando Galeano-Vanegas and
  • Carlos Andrés Naranjo-Galvis

15 September 2025

Background: Autism Spectrum Disorder (ASD) is increasingly associated with alterations in gut microbiota, intestinal permeability, and immune dysregulation. However, integrative studies exploring these mechanisms in Latin American populations are lac...

  • Article
  • Open Access
12 Citations
7,517 Views
19 Pages

22 April 2015

Autism spectrum disorders are a group of mental illnesses highly correlated with gastrointestinal dysfunction. Recent studies have shown that there may be one or more microbial “fingerprints” in terms of the composition characterizing individuals wit...

  • Review
  • Open Access
50 Citations
13,029 Views
25 Pages

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

  • Dinyadarshini Johnson,
  • Vengadesh Letchumanan,
  • Sivakumar Thurairajasingam and
  • Learn-Han Lee

3 July 2020

The study of human microbiota and health has emerged as one of the ubiquitous research pursuits in recent decades which certainly warrants the attention of both researchers and clinicians. Many health conditions have been linked to the gut microbiota...

  • Article
  • Open Access
769 Views
12 Pages

Extended-spectrum beta-lactamase (ESBL)-producing E. coli from broiler farms can reach watersheds used for recreational swimming. We assessed short-term swimmer exposure by extending a modular quantitative microbial risk assessment (QMRA) to the recr...

  • Review
  • Open Access
6 Citations
4,928 Views
18 Pages

10 August 2022

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by diverse behavioral symptoms such as repetitive behaviors, social deficits, anxiety, hyperactivity, and irritability. Despite their increasing incidence, the specific pa...

  • Article
  • Open Access
2 Citations
9,111 Views
17 Pages

GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control

  • Alyce J. Mayfosh,
  • Zoe I. Day,
  • Nathan B. Unsworth,
  • Chun-Qiang Liu,
  • Ruchi Gupta,
  • Soraya Haynes,
  • Rebecca Abraham,
  • Sam Abraham,
  • Zo L. Shaw and
  • Sumeet Walia
  • + 3 authors

13 September 2022

The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scien...

  • Editorial
  • Open Access
5 Citations
4,878 Views
8 Pages

The Biomolecular Spectrum Drives Microbial Biology and Functions in Agri-Food-Environments

  • Minaxi Sharma,
  • Dhananjaya Pratap Singh,
  • Kanchugarakoppal S. Rangappa,
  • Marc Stadler,
  • Pradeep Kumar Mishra,
  • Roberto Nascimento Silva,
  • Ram Prasad and
  • Vijai Kumar Gupta

4 March 2020

Microbial biomolecules have huge commercial and industrial potential. In nature, biological interactions are mostly associated with biochemical and biological diversity, especially with the discovery of associated biomolecules from microbes. Within c...

  • Article
  • Open Access
117 Citations
14,387 Views
26 Pages

New and Preliminary Evidence on Altered Oral and Gut Microbiota in Individuals with Autism Spectrum Disorder (ASD): Implications for ASD Diagnosis and Subtyping Based on Microbial Biomarkers

  • Xuejun Kong,
  • Jun Liu,
  • Murat Cetinbas,
  • Ruslan Sadreyev,
  • Madelyn Koh,
  • Hui Huang,
  • Adetaye Adeseye,
  • Puhan He,
  • Junli Zhu and
  • Hugh Russell
  • + 3 authors

6 September 2019

Autism Spectrum Disorder (ASD) is a complex neurological and developmental disorder characterized by behavioral and social impairments as well as multiple co-occurring conditions, such as gastrointestinal abnormalities, dental/periodontal diseases, a...

  • Article
  • Open Access
1 Citations
917 Views
9 Pages

The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study

  • Naoyuki Yamada,
  • Nanako Iwamoto,
  • Ayano Sakuma,
  • Junki Sunada,
  • Ren Aoki,
  • Masanori Mikuni,
  • Fumiaki Higashijima,
  • Takuya Yoshimoto,
  • Yukiko Morita and
  • Kazuhiro Kimura

27 February 2025

Purpose: To elucidate pathogen-specific seasonal patterns in infectious keratitis through a comprehensive long-term analysis of microbiologically proven cases in a Japanese tertiary care center. Methods: This retrospective study analyzed 500 consecut...

  • Article
  • Open Access
1 Citations
1,214 Views
12 Pages

Microbial Spectrum, Intraoperative Findings, and Postoperative Outcomes in Native Knee Joint Infections: A Retrospective Analysis

  • Jonas Roos,
  • Britta Mangels,
  • Max Jaenisch,
  • Matthias Dominik Wimmer,
  • Thomas Martin Randau,
  • Christian Prangenberg,
  • Kristian Welle and
  • Martin Gathen

16 December 2024

Background: Native knee joint infections, while uncommon, present a serious condition predominantly instigated by bacteria such as Staphylococcus aureus. Without timely intervention, they can result in joint destruction or sepsis, with risk factors e...

  • Article
  • Open Access
121 Views
21 Pages

5 December 2025

Antimicrobial resistance (AMR) poses a global health threat, which is becoming more challenging due to the involvement of bacterial virulence mechanisms such as quorum sensing (QS) and biofilm formation. These systems regulate pathogenic traits and s...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,948 Views
14 Pages

4 November 2020

Alcohol dehydrogenases catalyse the conversion of a large variety of ketone substrates to the corresponding chiral products. Due to their high regio- and stereospecificity, they are key components in a wide range of industrial applications. A novel a...

  • Article
  • Open Access
11 Citations
3,578 Views
12 Pages

Poultry frequently account for the highest prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in livestock. To investigate the impact of direct-fed microbials (DFM) and phytobiotic feed additives on prevalence and conj...

  • Article
  • Open Access
19 Citations
4,362 Views
16 Pages

Alterations of the Intestinal Permeability are Reflected by Changes in the Urine Metabolome of Young Autistic Children: Preliminary Results

  • Cristina Piras,
  • Michele Mussap,
  • Antonio Noto,
  • Andrea De Giacomo,
  • Fernanda Cristofori,
  • Martina Spada,
  • Vassilios Fanos,
  • Luigi Atzori and
  • Ruggiero Francavilla

23 January 2022

Several metabolomics-based studies have provided evidence that autistic subjects might share metabolic abnormalities with gut microbiota dysbiosis and alterations in gut mucosal permeability. Our aims were to explore the most relevant metabolic pertu...

  • Article
  • Open Access
1,351 Views
14 Pages

28 June 2024

Introduction: Patients with chronic pancreatitis (CP) as well as with pancreatic head carcinoma (CA) undergo the surgical intervention named “pylorus-preserving pancreatoduodenectomy according to Traverso–Longmire (PPPD)”, which all...

  • Review
  • Open Access
31 Citations
9,455 Views
26 Pages

Novel antimicrobial drugs are urgently needed to counteract the increasing occurrence of bacterial resistance. Extracts of Cannabis sativa have been used for the treatment of several diseases since ancient times. However, its phytocannabinoid constit...

  • Article
  • Open Access
28 Citations
8,303 Views
17 Pages

9 October 2018

Sugarcane (Saccharum spp. hybrid) successive planting (also called monoculture) causes serious yield losses and its management is not well studied in Histosols. Based on very few studies in other sugarcane regions, root colonization by harmful soil f...

  • Article
  • Open Access
3 Citations
2,247 Views
10 Pages

Aerobic Microbiological Spectrum and Antibiotic Resistance in Children Operated for Anorectal Abscesses

  • Dzhevdet Chakarov,
  • Elena Hadzhieva,
  • Yordan Kalchev and
  • Dimitar Hadzhiev

20 April 2024

(1) Background: Anorectal abscesses are a relatively rare pathology in childhood. Most often, male children under 1 year of age are affected. The importance of microbiological examination for the diagnosis and treatment of such patients remains...

  • Review
  • Open Access
6 Citations
4,263 Views
30 Pages

Autism Spectrum Disorder, Oral Implications, and Oral Microbiota

  • Emiliana D’Angelo,
  • Fausto Fiori,
  • Giuseppe A. Ferraro,
  • Assunta Tessitore,
  • Luca Nazzaro,
  • Rosario Serpico and
  • Maria Contaldo

15 March 2025

Background/Objectives: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social interaction, communication, and repetitive behaviors. Recent evidence indicates a significant relationship between...

  • Article
  • Open Access
3 Citations
1,916 Views
20 Pages

Knowledge of the microbiota present in food processing environments is a significant advance that will allow for better evaluation of the risk of food contamination and a better design of the procedures for sanitization. The levels of microbial group...

  • Feature Paper
  • Article
  • Open Access
7 Citations
2,776 Views
20 Pages

Onion (Allium cepa L.), a globally cultivated vegetable crop, possesses a shallow root system, making it vulnerable to abiotic stresses. The increasing frequency of extreme weather events in recent years necessitates sustainable solutions to enhance...

  • Article
  • Open Access
4 Citations
2,077 Views
17 Pages

Biostimulants play an active role in sustainable crop production. While biostimulants are thought to have long-term effects on plant growth, little research has been conducted to confirm this hypothesis. In this study, we investigated the long-term r...

  • Feature Paper
  • Review
  • Open Access
2 Citations
3,393 Views
13 Pages

Recent advances in the microbial degradation of persistent organic pollutants have the potential to mitigate the damage caused by anthropogenic activities that are harmfully impacting agriculture soil ecosystems and human health. In this paper, we su...

  • Article
  • Open Access
29 Citations
6,389 Views
16 Pages

Studies on Optimization of Sustainable Lactic Acid Production by Bacillus amyloliquefaciens from Sugarcane Molasses through Microbial Fermentation

  • Balasubramanian Vignesh Kumar,
  • Balakrishnan Muthumari,
  • Murugan Kavitha,
  • John Kennedy John Praveen Kumar,
  • Subbu Thavamurugan,
  • Alagarsamy Arun and
  • Muthuramalingam Jothi Basu

16 June 2022

Lactic acid is the meekest hydroxyl carboxylic acid (2-hydroxy propionic acid) which is a colorless, odorless, hygroscopic, organic compound with no toxic effect, a very inevitable and versatile chemical used in the Food, cosmetics, textile, and phar...

  • Article
  • Open Access
2 Citations
1,951 Views
17 Pages

Spectral Algal Fingerprinting and Long Sequencing in Synthetic Algal–Microbial Communities

  • Ayagoz Meirkhanova,
  • Sabina Marks,
  • Nicole Feja,
  • Ivan A. Vorobjev and
  • Natasha S. Barteneva

14 September 2024

Synthetic biology has advanced in creating artificial microbial and algal communities, but technical and evolutionary complexities still pose significant challenges. Traditional methods, like microscopy and pigment analysis, are limited in throughput...

  • Article
  • Open Access
6 Citations
4,639 Views
28 Pages

Preliminary Study on Light-Activated Antimicrobial Agents as Photocatalytic Method for Protection of Surfaces with Increased Risk of Infections

  • Razvan Bucuresteanu,
  • Lia-Mara Ditu,
  • Monica Ionita,
  • Ioan Calinescu,
  • Valentin Raditoiu,
  • Bogdan Cojocaru,
  • Ludmila Otilia Cinteza,
  • Carmen Curutiu,
  • Alina Maria Holban and
  • Marius Enachescu
  • + 6 authors

14 September 2021

Preventing and controlling the spread of multidrug-resistant (MDR) bacteria implicated in healthcare-associated infections is the greatest challenge of the health systems. In recent decades, research has shown the need for passive antibacterial prote...

  • Article
  • Open Access
6 Citations
2,920 Views
14 Pages

The In Vitro Antibacterial Activity of Argirium SUNc against Most Common Pathogenic and Spoilage Food Bacteria

  • Andrea Mancusi,
  • Marica Egidio,
  • Raffaele Marrone,
  • Luca Scotti,
  • Domenico Paludi,
  • Irene Dini and
  • Yolande Thérèse Rose Proroga

Foodborne diseases are one of the main issues for human health, and antibacterial packaging plays a major role in food security assurance. Silver ultra nanoparticles (Argirium SUNc) are antimicrobial agents that have a wide spectrum of action, includ...

  • Review
  • Open Access
1 Citations
1,915 Views
22 Pages

New Strategy for Microbial Corrosion Protection: Photocatalytic Antimicrobial Quantum Dots

  • Shijia Liu,
  • Dapeng Wu,
  • Jie Zheng,
  • Baochen Han,
  • Jian Qi,
  • Fanchun Meng,
  • Jianhui Li and
  • Dan Liu

24 December 2024

Microbial corrosion has significant implications for the economy, environment, and human safety worldwide. Photocatalytic antibacterial technology, owing to its advantages in environmental protection, broad-spectrum, and efficient sterilization, pres...

  • Review
  • Open Access
42 Citations
8,959 Views
28 Pages

Chemistry and Biology of Siderophores from Marine Microbes

  • Jianwei Chen,
  • Yuqi Guo,
  • Yaojia Lu,
  • Bixia Wang,
  • Jiadong Sun,
  • Huawei Zhang and
  • Hong Wang

29 September 2019

Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine m...

  • Article
  • Open Access
2 Citations
3,054 Views
16 Pages

4 February 2023

Pulsed light (PL) is a novel, non-thermal technology being used to control the microbial spoilage of foods and beverages. Adverse sensory changes, commonly characterized as “lightstruck”, can occur in beers when exposed to the UV portion...

  • Article
  • Open Access
11 Citations
3,416 Views
11 Pages

Copper has intrinsic antimicrobial properties. Wound dressings impregnated with cuprous oxide microparticles (hereafter termed COD) have been cleared for the management of acute and chronic wounds by the FDA and other regulatory bodies. The COD reduc...

  • Commentary
  • Open Access
2 Citations
3,128 Views
6 Pages

Despite an increasing number of techniques that are designed to mitigate microbial contamination of food and the resulting food borne disease outbreaks, the United States and many other countries across the world continue to experience impressive num...

  • Abstract
  • Open Access
1,512 Views
1 Page

Broad-Spectrum Activity of Antimicrobial Peptoids

  • Gill Diamond,
  • Erika Figgins,
  • Denny Gao,
  • Annelise E. Barron and
  • Kent Kirshenbaum

Antimicrobial peptides (AMPs) are naturally occurring host defense molecules, representing an evolutionarily ancient, innate immune mechanism against pathogenic infection. As such, many of these predominantly cationic and amphipathic peptides have be...

  • Article
  • Open Access
32 Citations
5,516 Views
15 Pages

Nitrofurantoin—Microbial Degradation and Interactions with Environmental Bacterial Strains

  • Amanda Pacholak,
  • Wojciech Smułek,
  • Agnieszka Zgoła-Grześkowiak and
  • Ewa Kaczorek

The continuous exposure of living organisms and microorganisms to antibiotics that have increasingly been found in various environmental compartments may be perilous. One group of antibacterial agents that have an environmental impact that has been v...

  • Brief Report
  • Open Access
5 Citations
8,535 Views
6 Pages

Shotgun Metagenomic Sequencing Identifies Dysbiosis in Triplet Sibling with Gastrointestinal Symptoms and ASD

  • Sabine Hazan,
  • Kimberly D. Spradling-Reeves,
  • Andreas Papoutsis and
  • Stephen J. Walker

25 November 2020

The gut microbiome profile of a child with autism spectrum disorder (ASD) and co-occurring gastrointestinal (GI) symptoms was compared to that of her healthy triplet siblings to determine if she exhibited intestinal dysbiosis. Shotgun metagenomic seq...

  • Article
  • Open Access
937 Views
15 Pages

Difenoconazole Degradation by Novel Microbial Consortium TA01: Metabolic Pathway and Microbial Community Analysis

  • Tianyue Wang,
  • Jingyi Sui,
  • Yi Zhou,
  • Liping Wang,
  • Jia Yang,
  • Feiyu Chen,
  • Xiuming Cui,
  • Ye Yang and
  • Wenping Zhang

Difenoconazole, a broad-spectrum systemic fungicide, can effectively prevent and control plant diseases such as rice blast, leaf spot, and black spot caused by Colletotrichum godetiae, Alternaria alternata, and Neopestalotiopsis rosae. However, its r...

  • Article
  • Open Access
3 Citations
2,087 Views
19 Pages

Microbial Profile and Antibiotic Resistance Patterns in Bile Aspirates from Patients with Acute Cholangitis: A Multicenter International Study

  • Matei-Alexandru Cozma,
  • Mihnea-Alexandru Găman,
  • Camelia Cristina Diaconu,
  • Arthur Berger,
  • Frank Zerbib and
  • Radu Bogdan Mateescu

Objectives: Significant differences in antibiotic resistance (AR) rates and multi-drug resistant (MDR) bacteria incidence exist in patients with acute cholangitis (AC) from different countries or regions. We aim to characterize and compare the microb...

  • Article
  • Open Access
7 Citations
3,149 Views
11 Pages

Multidrug-Resistant Urinary Tract Infections in Pregnant Patients and Their Association with Adverse Pregnancy Outcomes—A Retrospective Study

  • Gabriel-Ioan Anton,
  • Liliana Gheorghe,
  • Viorel-Dragos Radu,
  • Ioana-Sadiye Scripcariu,
  • Ingrid-Andrada Vasilache,
  • Alexandru Carauleanu,
  • Iustina-Solomon Condriuc,
  • Razvan Socolov,
  • Pavel Onofrei and
  • Andreea-Ioana Pruteanu
  • + 3 authors

6 November 2024

Background/Objectives: Multidrug-resistant urinary tract infections (MDR UTIs) constitute an important public health problem, especially in pregnant patients. The aim of this retrospective study was to characterize the bacterial spectrum and the prof...

  • Review
  • Open Access
67 Citations
17,807 Views
31 Pages

The fundamental feature of “active honeys” is the presence and concentration of antibacterial compounds. Currently identified compounds and factors have been described in several review papers without broader interpretation or links to the proce...

  • Review
  • Open Access
4 Citations
3,605 Views
20 Pages

29 February 2024

Plants select microorganisms from the surrounding bulk soil, which act as a reservoir of microbial diversity and enrich a rhizosphere microbiome that helps in growth and stress alleviation. Plants use organic compounds that are released through root...

  • Article
  • Open Access
3 Citations
1,485 Views
15 Pages

Microbiota-Derived L-SeMet Potentiates CD8+ T Cell Effector Functions and Facilitates Anti-Tumor Responses

  • Simiao Fan,
  • Yaxin Li,
  • Shaoyi Huang,
  • Wen Wang,
  • Biyu Zhang,
  • Jiamei Zhang,
  • Xiaoxiao Jian,
  • Zengqing Song,
  • Min Wu and
  • Haiqing Tu
  • + 4 authors

Extensive studies have shown that gut microbiota-derived metabolites can enhance the antitumor efficacy of immunotherapy by modulating host immune responses. However, the more comprehensive spectrum of such metabolites and their mechanisms remain unc...

  • Article
  • Open Access
9 Citations
4,381 Views
28 Pages

Applying Differential Neural Networks to Characterize Microbial Interactions in an Ex Vivo Gastrointestinal Gut Simulator

  • Misael Sebastián Gradilla-Hernández,
  • Alejandro García-González,
  • Anne Gschaedler,
  • Enrique J. Herrera-López,
  • Marisela González-Avila,
  • Ricardo García-Gamboa,
  • Carlos Yebra Montes and
  • Rita Q. Fuentes-Aguilar

16 May 2020

The structure of mixed microbial cultures—such as the human gut microbiota—is influenced by a complex interplay of interactions among its community members. The objective of this study was to propose a strategy to characterize microbial i...

  • Review
  • Open Access
26 Citations
8,800 Views
20 Pages

Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health

  • Sylvia H. Duncan,
  • Elena Conti,
  • Liviana Ricci and
  • Alan W. Walker

A dense microbial community resides in the human colon, with considerable inter-individual variability in composition, although some species are relatively dominant and widespread in healthy individuals. In disease conditions, there is often a reduct...

  • Article
  • Open Access
4 Citations
2,544 Views
16 Pages

28 August 2023

Short shelf-life and poor microbial quality of minimally processed foods of plant origin pose a serious problem for the food industry. Novel techniques of minimal treatment combined with disinfection are being researched, and, for fresh juice, the ad...

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