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Chemistry and Biology of Siderophores from Marine Microbes

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College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
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Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20878, USA
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 562; https://doi.org/10.3390/md17100562
Received: 3 September 2019 / Revised: 22 September 2019 / Accepted: 29 September 2019 / Published: 29 September 2019
Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes. View Full-Text
Keywords: siderophores; marine microbes; synthesis; biosynthesis siderophores; marine microbes; synthesis; biosynthesis
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Chen, J.; Guo, Y.; Lu, Y.; Wang, B.; Sun, J.; Zhang, H.; Wang, H. Chemistry and Biology of Siderophores from Marine Microbes. Mar. Drugs 2019, 17, 562.

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