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Chemistry and Biology of Siderophores from Marine Microbes

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20878, USA
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 562;
Received: 3 September 2019 / Revised: 22 September 2019 / Accepted: 29 September 2019 / Published: 29 September 2019
Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes. View Full-Text
Keywords: siderophores; marine microbes; synthesis; biosynthesis siderophores; marine microbes; synthesis; biosynthesis
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Chen, J.; Guo, Y.; Lu, Y.; Wang, B.; Sun, J.; Zhang, H.; Wang, H. Chemistry and Biology of Siderophores from Marine Microbes. Mar. Drugs 2019, 17, 562.

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